SOME OBSERVATIONS ON THE STIMULATION OF ERYTHROPOIESIS BY HUMORAL FACTORS

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Homotransplantation of multiple visceral organs

It was technically possible to perform simultaneous homotransplantation of multiple visceral organs including the liver, spleen, pancreas, omentum and the entire gastrointestinal tract. Arterialization of the cooled graft was accomplished through the donor aorta which was removed with the graft and attached to that of the recipient dog. Gastrointestinal hemorrhage after surgery accounted for a high operative mortality and was thought to be due to denervation of the graft. The five dogs which survived the immediate trauma of surgery lived for five and a half to nine days. After the second day, these animals were physically active and able to resume oral alimentation. In three dogs, there was metabolic evidence of rejection of the liver. In two others, jaundice did not develop. These observations were compared with chemical, hematologic and pathologic data obtained in previous experiments involving homotransplantation of the liver alone. In some cases, there was less evidence of host versus graft rejection after the multiple organ transplants. Other data in the present study suggested the possibility that a significant graft versus host reaction may have been an important contributory cause of death. © 1962

Atomic Energy Commission Report AECU-3152

Progress report includes reports on (1) The isolation of pyrimidine deoxynucleotides from the acid-soluble fraction of thymus; (2) Non-specific protective effect of small lead shields against the lethal effects of whole body irradiation in the rat; (3) Strain differences in response to whole body irradiation and shielding procedures in the rat; (4) Renal clearance procedures in an evaluation of the effects of X-irradiation on renal function in a rat. A preliminary report; (5) The plasma erythropoietic stimulating factor. Observations on circulation erythrocytes and bone marrow of rats receiving protein-free extracts of rabbit plasma; (6)Additional observations on the plasma erythropoietic stimulating factor; (7) Studies on Trichinella Spiralia, VI-IX. (8) Effect of gamma radiation on infectivity of ascaris eggs. (9) Preliminary report of studies on taeniasis. (10) Studies on the role of labile humoral factors in irradiation injury. (11) Services of the Radiation Physics Unit. (12) Biological and physical effects of low energy monochromatic X-rays