3,474 research outputs found
Organs from animals for man
In the following review some of the problems of xenotransplantation shall be discussed, based on the few experimental data available so far and on reports in the literature describing investigations which may be of importance for xenotransplantation. The impact of gravity on the upright posture of man versus almost all other mammals, the dysfunction between enzymes and hormones in different species and the lack of interactions between interleukins, cytokines and vasoactive substances will be taken into consideration. The question must be asked whether different levels of carrier molecules or serum proteins play a role in the physiological network. Even though the development of transgenic animals or other imaginative manipulations may lead to the acceptance of any type of xenografted organ, it has to be established for how long the products of the xenografts are able to act in the multifactorial orchestra. We are far from understanding xenogeneic molecular mechanisms involved in toxicity, necrosis and apoptosis or even reperfusion injury and ischemia in addition to the immediate mechanisms of the hyperacute xenogeneic rejection. Here, cell adhesion, blood clotting and vasomotion collide and bring micro-and macrocirculation to a standstill. All types of xenogeneic immunological mechanisms studied so far were found to have a more serious impact than those seen in allogeneic transplantation. In addition we are now only beginning to understand that so-called immunological parameters in allogeneic mechanisms act also in a true physiological manner in the xenogeneic situation. These molecular mechanisms occur behind the curtain of hyperacute, accelerated, acute or chronic xenograft rejection of which only some folds have been lifted to allow glimpses of part of the total scene. Other obstacles are likely to arise when long-term survival is achieved. These obstacles include retroviral infections, transfer of prions and severe side effects of the massive immunosuppression which will be needed. Moral, ethical and religious concerns are under debate and the species-specific production of proteins of the foreign donor species developed for clinical use suddenly appears to be a greater problem than anticipated
Holographic data storage in a DX-center material
We report on the optical storage of digital data in a semiconductor sample containing DX centers. The diffraction efficiency and the bit-error-rate performance of multiplexed data images are shown to agree well with a simple model of the material. Uniform storage without an exposure schedule is demonstrated. The volume sensitivity is found to be ~10^3 times that of LiNBO3:Fe. The importance of coherent addition of scattered light with diffracted light in holographic data storage is discussed
On high-order pressure-robust space discretisations, their advantages for incompressible high Reynolds number generalised Beltrami flows and beyond
An improved understanding of the divergence-free constraint for the
incompressible Navier--Stokes equations leads to the observation that a
semi-norm and corresponding equivalence classes of forces are fundamental for
their nonlinear dynamics. The recent concept of {\em pressure-robustness}
allows to distinguish between space discretisations that discretise these
equivalence classes appropriately or not. This contribution compares the
accuracy of pressure-robust and non-pressure-robust space discretisations for
transient high Reynolds number flows, starting from the observation that in
generalised Beltrami flows the nonlinear convection term is balanced by a
strong pressure gradient. Then, pressure-robust methods are shown to outperform
comparable non-pressure-robust space discretisations. Indeed, pressure-robust
methods of formal order are comparably accurate than non-pressure-robust
methods of formal order on coarse meshes. Investigating the material
derivative of incompressible Euler flows, it is conjectured that strong
pressure gradients are typical for non-trivial high Reynolds number flows.
Connections to vortex-dominated flows are established. Thus,
pressure-robustness appears to be a prerequisite for accurate incompressible
flow solvers at high Reynolds numbers. The arguments are supported by numerical
analysis and numerical experiments.Comment: 43 pages, 18 figures, 2 table
Effect of time delay on feedback control of a flashing ratchet
It was recently shown that the use of feedback control can improve the
performance of a flashing ratchet. We investigate the effect of a time delay in
the implementation of feedback control in a closed-loop collective flashing
ratchet, using Langevin dynamics simulations. Surprisingly, for a large
ensemble, a well-chosen delay time improves the ratchet performance by allowing
the system to synchronize into a quasi-periodic stable mode of oscillation that
reproduces the optimal average velocity for a periodically flashing ratchet.
For a small ensemble, on the other hand, finite delay times significantly
reduce the benefit of feedback control for the time-averaged velocity, because
the relevance of information decays on a time scale set by the diffusion time
of the particles. Based on these results, we establish that experimental use of
feedback control is realistic.Comment: 6 pages, 6 figures, to appear in Europhysics Letter
Breast cancer: Monitoring response to neoadjuvant chemotherapy using Tc-99m sestamibi scintimammography
Background: Aim of the study was to assess the value of scintimammography using Tc-99m sestamibi in the evaluation of tumor response to neoadjuvant chemotherapy. Material and Methods: Results were calculated for 9 patients undergoing neoadjuvant chemotherapy. Scintimammography using 740 MBq Tc-99m sestamibi was performed before, during and after chemotherapy, and sestamibi uptake was scored visually and semiquantitatively to evaluate tumor response. Results: In the case of complete response (n = 3) sestamibi uptake decreased 8 days after beginning neoadjuvant chemotherapy and normalized in the following course. Focal uptake decreased more slowly in patients with partial response (n = 3), who showed clear, persisting tracer accumulation after therapy. The patients without response (n = 3) showed a persisting high tumor activity even after chemotherapy was completed. Conclusions: The preliminary data suggest that in contrast to other imaging modalities scintimammography appears to yield early information regarding tumor response to neoadjuvant chemotherapy
Low-lying fermion modes of Nf=2 improved Wilson fermions
We present preliminary results for the topological charge and susceptibility
determined from the low-lying eigenmodes of the Wilson-Dirac operator. These
modes have been computed on dynamical configurations with Nf=2
non-perturbatively improved Wilson fermions. We compare our results with the
eigenmodes of fermions in the quenched approximation.Comment: Lattice2001(confinement), 3 pages, 5 Figure
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Enhancing engagement in evidence-based tobacco cessation treatment for smokers with mental illness: A pilot randomized trial.
ObjectiveTo evaluate the efficacy of a brief telephone-delivered Motivational Interviewing (MI)-based intervention to facilitate engagement in evidence-based cessation treatment for Veterans with mental illness referred to smoking cessation treatment.Methods86 military Veteran smokers with mental illness were recruited from a tobacco cessation consult clinic and randomized to receive either a MI-based treatment engagement intervention (TE; n = 48) or a non-MI assessment and information control (CON; n = 38) condition. Intervention was delivered during a single brief telephone contact. Primary engagement outcomes were 1) attending a treatment session within 30 days and 2) combination treatment (attending session plus using pharmacotherapy). Cessation outcomes included self-reported 24 h cessation attempts and 7 day point abstinence at 3 months post-intervention. Outcomes were assessed at 1 and 3 months post intervention.ResultsOutcome analyses included 85 participants (47 TE, 38 CON) using an intent-to-treat analytic approach. Participants were on average 49.5 (13.4) years old, 88% Male, 59% white, 18% African American and 14% Hispanic/Latino(a). Following intervention delivery TE and CON participants did not differ on likelihood of attending a treatment session during the subsequent 30 days (47% vs 45%, respectively). A significant difference was observed when classified as utilizing combination treatment, 40% of TE versus 18% of CON reported use of smoking cessation medication and behavioral counseling (p = 0.04). No statistical differences were observed for cessation outcomes, although more TE than CON participants reported 7 day point abstinence at 3 months post-intervention (30% vs 18%).ConclusionsThe present pilot study provides initial evidence for the feasibility, acceptability and efficacy of a telephone delivered TE intervention for enhancing engagement in combinationevidence evidence-based treatment in a sample of Veteran smokers with mental illness referred to smoking cessation treatment. Smokers with mental illness typically have greater difficulty stopping smoking than those without mental illness. Increased engagement in combination treatment thus has the potential to increase quit rates and ultimately reduce the burden of tobacco use for this population
Optimizing Stimulation and Analysis Protocols for Neonatal fMRI
The development of brain function in young infants is poorly understood. The core challenge is that infants have a limited behavioral repertoire through which brain function can be expressed. Neuroimaging with fMRI has great potential as a way of characterizing typical development, and detecting abnormal development early. But, a number of methodological challenges must first be tackled to improve the robustness and sensitivity of neonatal fMRI. A critical one of these, addressed here, is that the hemodynamic response function (HRF) in pre-term and term neonates differs from that in adults, which has a number of implications for fMRI. We created a realistic model of noise in fMRI data, using resting-state fMRI data from infants and adults, and then conducted simulations to assess the effect of HRF of the power of different stimulation protocols and analysis assumptions (HRF modeling). We found that neonatal fMRI is most powerful if block-durations are kept at the lower range of those typically used in adults (full on/off cycle duration 25-30s). Furthermore, we show that it is important to use the age-appropriate HRF during analysis, as mismatches can lead to reduced power or even inverted signal. Where the appropriate HRF is not known (for example due to potential developmental delay), a flexible basis set performs well, and allows accurate post-hoc estimation of the HRF
Mechanical coupling in flashing ratchets
We consider the transport of rigid objects with internal structure in a
flashing ratchet potential by investigating the overdamped behavior of a
rod-like chain of evenly spaced point particles. In 1D, analytical arguments
show that the velocity can reverse direction multiple times in response to
changing the size of the chain or the temperature of the heat bath. The
physical reason is that the effective potential experienced by the mechanically
coupled objects can have a different symmetry than that of individual objects.
All analytical predictions are confirmed by Brownian dynamics simulations.
These results may provide a route to simple, coarse-grained models of molecular
motor transport that incorporate an object's size and rotational degrees of
freedom into the mechanism of transport.Comment: 9 pages, 10 figure
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