An explicit closed-form solution for transverse and longitudinal vibration of beam with multi-directional elastic constraints under an arbitrary moving load

Beams with elastic constraints are widely used in dynamic systems in engineering. A general explicit solution is presented here for the vibration of simple span beam with transverse, rotational and axial elastic boundary constraints due to an arbitrary moving load. The Euler-Bernoulli beam theory is adopted, in which the boundary constraints are treated as multi-directional boundary springs. After the modal analyses, the explicit closed-form solutions of transverse and axial vibration of the beam under a constant, sinusoidal and cosinoidal moving loads are obtained, respectively. And the vibration of a beam subjected to an arbitrary moving load is derived by the superposition of Fourier series. The current analytical solution is exact and can be applied in multiple engineering fields to obtain accurate structural vibrations. In numerical examples, the effects of the boundary springs on the natural frequencies, modes, deflection, bending moment and boundary reaction of the beam are studied in details. The effects of the number of terms in Fourier series of arbitrary moving load are also discussed

Meta-analysis of the effect of expression of MYB transcription factor genes on abiotic stress

Background MYB proteins are a large group of transcription factors. The overexpression of MYB genes has been reported to improve abiotic stress tolerance in plant. However, due to the variety of plant species studied and the types of gene donors/recipients, along with different experimental conditions, it is difficult to interpret the roles of MYB in abiotic stress tolerance from published data. Methods Using meta-analysis approach, we investigated the plant characteristics involved in cold, drought, and salt stress in MYB-overexpressing plants and analyzed the degrees of influence on plant performance by experimental variables. Results The results show that two of the four measured plant parameters in cold-stressed plants, two of the six in drought-stressed, and four of the 13 in salt-stressed were significantly impacted by MYB overexpression by 22% or more, and the treatment medium, donor/recipient species, and donor type significantly influence the effects of MYB-overexpression on drought stress tolerance. Also, the donor/recipient species, donor type, and stress duration all significantly affected the extent of MYB-mediated salt stress tolerance. In summary, this study compiles and analyzes the data across studies to help us understand the complex interactions that dictate the efficacy of heterologous MYB expression designed for improved abiotic stress tolerance in plants

Associations of B Vitamin-Related Dietary Pattern during Pregnancy with Birth Outcomes: A Population-Based Study in Northwest China

This study aimed to derive a maternal dietary pattern to explain the variation in B vitamins during pregnancy and to investigate this pattern in relation to birth outcomes. A total of 7347 women who gave birth to live newborns less than one year were included. Their dietary pattern during pregnancy was derived using the reduced-rank regression method with six B vitamins as response variables. Associations between dietary pattern score and birth weight, gestational age at delivery, birth weight Z score, low birth weight, preterm, and small-for-gestational-age (SGA) were estimated using generalised linear mixed models. We identified a high B-vitamin dietary pattern characterised by high intakes of animal foods, vegetables, fungi and algae, legumes, and low intakes of oils and cereals. Women in the highest quartile of this pattern score had newborns with a 44.5 g (95% CI: 13.8, 75.2 g) higher birth weight, 0.101 (95% CI: 0.029, 0.172) higher birth weight Z score, and 27.2% (OR: 0.728; 95% CI: 0.582, 0.910) lower risk of SGA than those in the lowest quartile. Our study suggested that adherence to the high B-vitamin dietary pattern during pregnancy was associated with a higher birth weight and a lower risk of SGA

Application of major histocompatibility complex in laboratory chickens

Chicken major histocompatibility complex (MHC) has been a research focus for its high polymorphism and close relation with varying resistance against diseases. It is located on a microchromosome (chromosome 16). It has been found that it has different resistance against diseases for different B haplotypes. The article gives a detailed introduction about structural characteristics, relation to diseases resistance, the progress in detection methods of chicken MHC, and the prospect of application of MHC in molecular breeding for disease resistance in chickens

Specific TaqMan probed real-time quantitative RT-PCR methods and their application to differentiate the transcripts of duplicated BF or BLB genes in chicken MHC

BF and BLB genes of chicken major histocompatibility complex (MHC) are responsible for classical antigen processing and presentation; therefore they play a central role in determining the genetic resistance or susceptibility of different MHC haplotypes to some infectious diseases. In this study, we developed specific TaqMan probed real-time quantitative reverse transcription PCR (TaqMan qRT-PCR) methods based on the diagnostic nucleotide polymorphisms present in duplicated BF or BLB genes in B2 and B19 haplotypes. The results showed very similar amplification efficiency but no cross-reaction between the duplicated BF or BLB genes of the same haplotype. Spleen mRNA samples of B2 and B19 chickens were used to validate these TaqMan qRT-PCR methods. We observed that BF2 or BLB2 gene was dominantly transcribed in all B2 and B19 chickens. Our findings verified the impact of diversified promoter sequences on the function of duplicated BF or BLB genes. Hence the principles adopted to establish these specific TaqMan qRT-PCR methods in this study can be applied to differentiate the transcripts of duplicated BF or BLB genes of other MHC-B haplotypes in chicken

Establishment of six homozygous MHC-B haplotype populations associated with susceptibility to Marek’s disease in Chinese specific pathogen-free BWEL chickens

The highly polymorphic chicken major histocompatibility complex (MHC) is associated with different levels of immunologic responses to certain avian pathogens. MHC-B haplotype chickens are an important genetic resource for studying the genetic determination of pathogen resistance and susceptibility. The BWEL chicken population is the only specific pathogen-free (SPF) chickens bred and developed by the State Center of Poultry Genetic Resources of Laboratory Animals in China. In this study, we successfully established six homozygous MHC-B haplotype populations from the BWEL chickens using microsatellite marker technology, named as BW/G(1, 2, 3, 5, 6, 7) lines, and their molecular genotypes were matched to six serologically defined MHC-B haplotypes, B13, B15, B2, B5, B21 and B19, respectively. The sequences of BF genes exons 2 and 3 from four successive generations (F1–F4) of the BW/G(n) lines were completely consistent with those of serologically defined MHC-B haplotypes. Subsequently, six BW/G(n) line specific allo-antisera were prepared by immunization with red blood cells (RBCs) and hemagglutination tests results showed the BW/G(n) SPF chickens could be serologically differentiated. Additionally, susceptibility to Marek’s disease (MD) in the BW/G3 (B2 haplotype) and BW/G7 (B19 haplotype) lines were determined by comparing mortality, macroscopic and histopathological lesions, and viral loads in feather pulp. The BW/G7 line showed greater genetic susceptibility to the very virulent MD virus (MDV) strain than the BW/G3 line. The establishment of MHC-B haplotype chicken populations associated with susceptibility to MD will be helpful for studying host immune responses and further developing the more effective vaccines in the context of MHC specificities, and they are also very useful for an understanding of MHC genes architecture and function

Genetic diversity of specific pathogen-free HBK-B and HBK-Q duck populations

in Chinese with English abstrac

Genetic Algorithms with Variant Particle Swarm Optimization Based Mutation for Generic Controller Placement in Software-Defined Networks

To enable learning-based network management and optimization, the 5th Generation Mobile Communication Technology and Internet of Things systems usually involve software-defined networking (SDN) architecture and multiple SDN controllers to efficiently collect the big volume of runtime statistics, define network-wide policies, and enforce the policies over the whole network. To better plan the placement of controllers over SDN systems, this article proposes a generic controller placement problem (GCP) that considers the organization and placement of controllers as well as the switch attachment to optimize the delay between controllers and switches, the delay among controllers, and the load imbalance among controllers. To solve this problem without losing generality, a novel multi-objective genetic algorithm (MOGA) with a mutation based on a variant Particle Swarm Optimization (PSO) is proposed. This PSO chooses a global best position for a particle according to a pre-computed global best position set to lead the mutation of the particle. It successfully handles multiple conflicting objectives, fits the scenario of mutation, and can apply in many other flavors of MOGAs. Evaluations over 12 real Internet service provider networks show the effectiveness of our MOGA in reducing convergence time and improving the diversity and accuracy of the Pareto frontiers. The proposed approaches in formulating and solving the GCP in this article are general and can be applied in many other optimization problems with minor modifications