Analytics of Phishing Attacks Using Machine Learning

Cyber-attacks which is known as Computer Network Attack (CAN). It is a threat created by cybercriminals by more than one computer against networks. There are various types of cyberattacks among them Phishing Attack is one of them. Phishing is a technique of gathering sensitive information of a target such as username, password, bank details etc. There are various ways to perform phishing attacks, among them URL PHISHING attack is one way to gather user’s information. Mainly hackers create a fake website regarding bank details, shopping websites, etc. using social engineering tool which looks like legitimate website. This fake URL will be sent to user via email or through some other resources. In this paper, we will be performing data analysis, data pre-processing, data exploring, training and predicting through machine learning and optimization techniques on dataset which contains two attributes (URL, Label). We will be introducing performance metrics like confusion matrix accuracy, precision, recall and F1 score to know the performance of the model. An optimization technique which is Stochastic gradient descent performed better than logistic regression

A SMART METER DESIGN AND IMPLEMENTATION

In this paper Wireless Sensor Home Area Network (WSHAN) with IOT interfaced sensible meter is established along with implemented. As a result of the increasing requirements on electric power, typical electric grid ought to be altered with wise, resilient, trusted as well as additionally pricey effective smart grid applications. Wireless Sensor Networks (WSN) has a crucial task to develop trustworthy in addition to costly reliable smart electric power grid applications. Our system establishes power usage logs details online as well as likewise exposes time of use well worth's. The system furthermore handles any type of sort of device connected to power end results. While powering on along with off, zero-cross of Air Conditioner signal is detected to figure out phase modification. The sensible meter provides appropriate power usage in addition to transfer’s details with WIFI to COMPUTER (Personal Computer). The private checks the power information as well as likewise from one more place manages the system. : In this paper Wireless Sensor Home Area Network (WSHAN) with IOT interfaced sensible meter is established along with implemented. As a result of the increasing requirements on electric power, typical electric grid ought to be altered with wise, resilient, trusted as well as additionally pricey effective smart grid applications. Wireless Sensor Networks (WSN) has a crucial task to develop trustworthy in addition to costly reliable smart electric power grid applications. Our system establishes power usage logs details online as well as likewise exposes time of use well worth's. The system furthermore handles any type of sort of device connected to power end results. While powering on along with off, zero-cross of Air Conditioner signal is detected to figure out phase modification. The sensible meter provides appropriate power usage in addition to transfer’s details with WIFI to COMPUTER (Personal Computer). The private checks the power information as well as likewise from one more place manages the system

TO EVALUATE THE SAFETY AND EFFICACY OF AMLODIPINE AND CHLORTHALIDONE IN COMBINATION WITH TELMISARTAN IN HYPERTENSIVE PATIENTS ATTENDING TERTIARY CARE CENTRE, TELANGANA

Objective: The main objective of this study is to evaluate and compare the effects of both treatments on systolic and diastolic blood pressure in 4th, and 8th weeks with baseline Methods: A prospective, comparative, Open-label, and parallel-group clinical study was conducted in out patient's department of general medicine at Osmania general hospital. 120 patients were randomly allocated into 2 groups. Group 1 with 60 patients received Tab: Telmisartan 40 mg+Amlodipine 5 mg once daily, and Group 2 with 60 patients received Tab: Telmisartan 40 mg+ Chlorthalidone 6.25 mg once daily for a period of 8 w. Follow-up was done in the 4th week and 8th week to evaluate the safety and efficacy in hypertensive patients. Results: The differences in the SBP, DBP, and HR in group A (P value<0.001) and group B (P value<0.001) at the 4th week and 8th week follow-up periods with baseline value (0 w) were statistically significant as P value<0.05. Conclusion: The combination of telmisartan plus amlodipine is equally effective as the combination of telmisartan plus chlorthalidone in decreasing SBP, DBP, HR, and MAP. No major adverse drug reactions were noted during the study period

Underground Coal Mining Methods and Their Impact on Safety

In underground coal mining, the working environment is completely enclosed by the geologic medium, which consists of the coal seam and overlying and underlying strata. Depillaring is one of the most dangerous phases of underground coal mining. Even after centuries of experience in underground coal mining, there is no well-established depillaring method w.r.t existing geo-mining method. As far as fatal accidents are concerned, most of the fatal accidents occur mostly during depillaring operations. Method of extraction is one of the keys and underrated parameters, which plays an eminent role in successful depillaring in underground coal mining. This chapter highlights the underground coal mining methods and their impact on safety

ROTIFERS ABUNDANCE AND THEIR RELATIONSHIP TO WATER QUALITY IN THE PANDU LAKE, BODHAN, TELANGANA, INDIA

Abstract: In the present study an attempt has been made to evaluate water quality and related density of rotifers for a period of two years, August 2002 to July 2004. A few water quality parameters such as dissolved Oxygen, biological oxygen demand, phosphates, and nitrates are presented here to relate with the abundance or cessation of rotifers. The present study has given an understanding that lake is transforming into nutrient rich water body

Characterization of Tg(Etv4-GFP) and Etv5RFP Reporter Lines in the Context of Fibroblast Growth Factor 10 Signaling During Mouse Embryonic Lung Development

Members of the PEA3 transcription factors are emerging as bone fide targets for fibroblast growth factor (FGF) signaling. Among them, ETV4 and ETV5 appear to mediate FGF10 signaling during early embryonic lung development. In this paper, recently obtained Tg(Etv4-GFP) and Etv5CreERT2−RFP fluorescent reporter lines were generally characterized during early embryonic development and in the context of FGF10 signaling, in particular. We found that both Tg(Etv4-GFP) and Etv5CreERT2−RFP were primarily expressed in the epithelium of the lung during embryonic development. However, the expression of Etv5CreERT2−RFP was much higher than that of Tg(Etv4-GFP), and continued to increase during development, whereas Tg(Etv4-GFP) decreased. The expression patterns of the surrogate fluorescent protein GFP and RFP for ETV4 and ETV5, respectively, agreed with known regions of FGF10 signaling in various developing organs, including the lung, where ETV4-GFP was seen primarily in the distal epithelium and to a lesser extent in the surrounding mesenchyme. As expected, ETV5-RFP was restricted to the lung epithelium, showing a decreasing expression pattern from distal buds to proximal conducting airways. FGF10 inhibition experiments confirmed that both Etv4 and Etv5 are downstream of FGF10 signaling. Finally, we also validated that both fluorescent reporters responded to FGF10 inhibition in vitro. In conclusion, these two reporter lines appear to be promising tools to monitor FGF10/FGFR2b signaling in early lung development. These tools will have to be further validated at later stages and in other organs of interest

A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis

This study demonstrates that FGF10/FGFR2b signaling on distal epithelial progenitor cells, via ß-catenin/EP300, controls, through a comprehensive set of developmental genes, morphogenesis, and differentiation. Fibroblast growth factor (FGF) 10 signaling through FGF receptor 2b (FGFR2b) is mandatory during early lung development as the deletion of either the ligand or the receptor leads to lung agenesis. However, this drastic phenotype previously hampered characterization of the primary biological activities, immediate downstream targets and mechanisms of action. Through the use of a dominant negative transgenic mouse model (Rosa26rtTA; tet(o)sFgfr2b), we conditionally inhibited FGF10 signaling in vivo in E12.5 embryonic lungs via doxycycline IP injection to pregnant females, and in vitro by culturing control and experimental lungs with doxycycline. The impact on branching morphogenesis 9 h after doxycycline administration was analyzed by morphometry, fluorescence and electron microscopy. Gene arrays at 6 and 9 h following doxycycline administration were carried out. The relationship between FGF10 and ß-catenin signaling was also analyzed through in vitro experiments using IQ1, a pharmacological inhibitor of ß-catenin/EP300 transcriptional activity. Loss of FGF10 signaling did not impact proliferation or survival, but affected both adherens junctions (up-regulation of E-cadherin), and basement membrane organization (increased laminin). Gene arrays identified multiple direct targets of FGF10, including main transcription factors. Immunofluorescence showed a down-regulation of the distal epithelial marker SOX9 and mis-expression distally of the proximal marker SOX2. Staining for the transcriptionally-active form of ß-catenin showed a reduction in experimental vs. control lungs. In vitro experiments using IQ1 phenocopied the impacts of blocking FGF10. This study demonstrates that FGF10/FGFR2b signaling on distal epithelial progenitor cells via ß-catenin/EP300 controls, through a comprehensive set of developmental genes, cell adhesion, and differentiation

Studies on guanidinyl pyrrolidine catalyzed conjugate additions and synthesis of (-)-pancracine and (+)-ipalbidine

The organocatalytic, asymmetric conjugate addition of carbon nucleophiles and heteroatom nucleophiles to enones is of interest because the products are useful synthetic intermediates. We have observed that these reactions are catalyzed by proline-derived guanidines. The present study examines the enantioselective addition of malonates, nitroalkanes and heteroatom nucleophiles to a variety of enones in order to provide the corresponding Michael adducts. The observations from this study provide some insight into the reactivity of amine-guanidine bifunctional catalyst motifs and lay the foundation for designing second generation catalysts having modulated nucleophilic and basic character. -- Enantiomerically pure γ-nitroketones and their derivatives are an important class of organic compounds due to their utility as building blocks for the asymmetric synthesis of natural products and biologically active molecules. In the present study, the organocatalytic Michael addition of a monoprotected cyclohexane 1,3-dione and selected β-nitro styrenes in the presence of a proline-derived triamine catalyst provided the conjugate addition products in good yield (83-90%), with high enantiomeric excess (89-99%) and high diastereoselectivity (≥19/1). These Michael adducts were utilized in a stereoselective synthesis of cis and trans-3-aryloctahydroindoles. Application of this methodology is presented in a short formal total synthesis of the methanomorphanthridine alkaloid (-)-pancracine. -- Enantiomerically enriched γ-nitroketones obtained from the triamine catalyzed organocatalytic Michael addition were also utilized as starting materials in an efficient synthesis of indolizidines. The utility of this methodology is highlighted by its application in a short total synthesis of the arylindolizidine alkaloid (+)-ipalbidine. The synthetic strategy has potential applications in the preparation of congeners and analogs of several arylindolizidine alkaloids

EFFECT OF BETULINIC ACID ON Spodoptera litura (Fab.) (LEPIDOPTERA: NOCTUIDAE)

Betulinic acid, a terpenoid isolated from the bark of Ziziphus jujuba, exhibited growth regulating activity against Spodoptera litura. The final instar larvae and zero hour pupae were treated with 0.1, 0.2 and 0.3 % concentrations of Betulinic acid in acetone. Betulinic acid interfered with moulting process resulting in formation of larval-pupal intermediates, abnormal pupae, pupal-adult intermediates and deformed adults resulting in inhibition of growth and propagation. Our results suggest that Betulinic acid shows an effective insect growth regulating activity and exhibits great promise in the control of the agricultural pest, Spodoptera litura

A PROSPECTIVE STUDY ON CLINICAL EVALUATION, TREATMENT PATTERN AND ADVERSE EFFECTS OF ANTICANCER DRUGS IN VARIOUS GYNAECOLOGICAL CANCER PATIENTS

Objective: The aim was to determine the prevalence, clinical presentation, treatment pattern, outcomes and adverse drug reactions of the treatmentregimen in gynecological cancer patients.Methods: This is a prospective observational study conducted at St. Ann's Cancer Hospital, Warangal, Telangana State, from January 2014 toSeptember 2014. 100 patients of gynecological cancer admitted in the hospital were divided into three groups, i.e. breast, cervical and ovariancancer. Patients receiving chemotherapy (CT) were interviewed for information on type of adverse effects (AE) and the other pertinent informationsuch as demographics, diagnosis, treatment pattern, drugs used to manage the AE were collected from the patient's medical records. The data werecategorized based on the type of cancers and AE of therapy.Results: A total of 50 patients were with breast cancer, 40 patients were with cervical cancer and 10 patients were with ovarian cancer. Amongbreast cancer patients, 24 patients (48%) belonged to a clinical sub group, 18 patients (45%) belonged to the early subgroup in cervical cancerand 5 patients (50%) belonged to the advanced subgroup in ovarian cancer. Most of the patients with breast cancer were reported with Stage IIIa(13 members, i.e. 26%), Stage I (13 members, i.e. 32.5%) in case of cervical cancer, Stage IIa (30%) and Stage IV (30%) in case of ovarian cancer.Surgery, followed by CT and radiotherapy (RT) was preferred in all cancer patients studied, i.e. 78%, 67.5%, 80% of breast, cervical and ovariancancers respectively. 78% of patients with breast cancer, 67.5% of patients with cervical cancer and 80% of patients with ovarian cancer have showncomplete response respectively. Hair loss/alopecia is the most common AE seen in 98 patients, followed by nausea and vomiting in 72 patients, nailpigmentation in 46 patients, pain in abdomen in 44 patients, loss of appetite in 31 patients, constipation in 29 patients, diarrhea in 27 patients, rash/dermatitis in 19 patients and headache in 13 patients.Conclusion: Breast cancer was found to be predominant. Most of the patients in gynecological cancer patients were found to be in the clinical stagegroup and an advanced stage group indicating lack of awareness about various cancers. Combination therapy (CT, RT and surgery) is said to have amajor effect on cancer patients, which resulted in improved quality of life and symptoms. All patients receiving cytotoxic drugs suffer one or more AE.The prevalence of AE was considerably high in spite of the using existing premedications.Keywords: Gynecological cancer, Tumor, Nodal, Metastasis staging, Combination therapy, Adverse effectsÂ