Exemestane major metabolism pathway.

<p>Exemestane major metabolism pathway.</p

Accuracy and Precision of Dilution Procedure for Exe.

<p>*Expressed as mean percentage (n = 4) of the mean value measured over the nominal value</p><p>^#Expressed as percentage of the standard deviation divided by the mean</p><p>Accuracy and Precision of Dilution Procedure for Exe.</p

Product ion mass spectra of (a) Exe (b) 17DhExe and (c) Exe17Oglu.

<p>Product ion mass spectra of (a) Exe (b) 17DhExe and (c) Exe17Oglu.</p

Mean concentrations of a) Exe (b) 17DhExe and (c) Exe17Oglu in plasma samples of one representative breast cancer patient.

<p>Mean concentrations of a) Exe (b) 17DhExe and (c) Exe17Oglu in plasma samples of one representative breast cancer patient.</p

Representative chromatograms of (a) Exe (b) 17DhExe and (c) Exe17Oglu at LLOQ and (a) Exe-d3, (b) DhExe-d3 as well as Exe17Oglu at 100 ng/mL as internal standards.

<p>Representative chromatograms of (a) Exe (b) 17DhExe and (c) Exe17Oglu at LLOQ and (a) Exe-d3, (b) DhExe-d3 as well as Exe17Oglu at 100 ng/mL as internal standards.</p

Box-plots showing the statistically insignificant associations between the nadir absolute neutrophil count and UGT1A1 genotypes.

<p>Box-plots showing the statistically insignificant associations between the nadir absolute neutrophil count and UGT1A1 genotypes.</p

CONSORT Flow Diagram for trial.

<p>CONSORT Flow Diagram for trial.</p

Box-plot showing the association between the rate constant of formation of raltegravir glucuronide from raltegravir (K₂₃) and presence or absence of dose delay amongst the patients.

<p>Box-plot showing the association between the rate constant of formation of raltegravir glucuronide from raltegravir (K₂₃) and presence or absence of dose delay amongst the patients.</p

UGT1A1 expression on belinostat glucuronidation and impact of the common UGT1A1*28 promoter polymorphism.

<p>A: Correlation of belinostat glucuronide formation with UGT1A1 expression in human liver microsomes; B: Belinostat glucuronide formation by human liver microsomes according to wild-type, heterozygous and homozygous UGT1A1*28 genotypes.</p

Identification of belinostat metabolites in human plasma using HPLC-DAD & LC-MS/MS analyses.

<p>Identification of belinostat metabolites in human plasma using HPLC-DAD & LC-MS/MS analyses.</p