10,830 research outputs found
Topical Diclofenac Solution for Osteoarthritis of the Knee: An Updated Meta-Analysis of Randomized Controlled Trials.
This study was performed to assess the efficacy and safety of a topical diclofenac solution in patients with knee osteoarthritis (OA). PubMed, Embase, Cochrane Library, Web of Science, and Scopus databases were searched for randomized controlled trials until June 2020. The WOMAC pain, stiffness, physical function subscales, pain on walking, and the occurrence of adverse events were pooled to comprehensively analyse the efficacy and safety of topical diclofenac solution. All statistical analyses were conducted using Review Manager 5.3 software. Five RCTs were included, which provided high-quality evidence. In comparison to the vehicle control, the mean differences for WOMAC pain, stiffness, and physical function subscales, as well as pain on walking, were all statistically significant in favor of topical diclofenac solution. The safety of topical diclofenac solution was similar to the vehicle control, apart from adverse events involving application-site skin reactions. Topical diclofenac solution is effective and safe for use in patients with knee OA, but may cause minor skin reactions
Study on Evolvement Complexity in an Artificial Stock Market
An artificial stock market is established based on multi-agent . Each agent
has a limit memory of the history of stock price, and will choose an action
according to his memory and trading strategy. The trading strategy of each
agent evolves ceaselessly as a result of self-teaching mechanism. Simulation
results exhibit that large events are frequent in the fluctuation of the stock
price generated by the present model when compared with a normal process, and
the price returns distribution is L\'{e}vy distribution in the central part
followed by an approximately exponential truncation. In addition, by defining a
variable to gauge the "evolvement complexity" of this system, we have found a
phase cross-over from simple-phase to complex-phase along with the increase of
the number of individuals, which may be a ubiquitous phenomenon in multifarious
real-life systems.Comment: 4 pages and 4 figure
Development of a microwave-based extraction for forensic biological samples
In this study, a quick microwave-based treatment was developed as a front end for DNA analysis of forensic samples. The effect of microwave treatment is to cause cell disruption which can improve the release of DNA during direct PCR as well as with extraction methods. Exposure to microwave preprocessing improved the quality of rapid genotyping, particularly when used with low level samples. Optimal results were obtained when samples were microwaved at 300W for 40 s, resulting in improved allele detection. Overall, the addition of this simple preprocessing step improves sensitivity and allele recovery for low level DNA samples when combined with expedited DNA analysis workflows. Its main advantages include speed, low cost, compatibility with downstream DNA methods and application to a wide variety of samples
Geometric observation for the Bures fidelity between two states of a qubit
In this Brief Report, we present a geometric observation for the Bures
fidelity between two states of a qubit.Comment: 4 pages, 1 figure, RevTex, Accepted by Phys. Rev.
Gold nanorods as a contrast agent for Doppler optical coherence tomography
Purpose: To investigate gold nanorods (GNRs) as a contrast agent to enhance Doppler optical coherence tomography (OCT) imaging of the intrascleral aqueous humor outflow. Methods: A serial dilution of GNRs was scanned with a spectral-domain OCT device (Bioptigen, Durham, NC) to visualize Doppler signal. Doppler measurements using GNRs were validated using a controlled flow system. To demonstrate an application of GNR enhanced Doppler, porcine eyes were perfused at constant pressure with mock aqueous alone or 1.0×10 12 GNR/mL mixed with mock aqueous. Twelve Doppler and volumetric SD-OCT scans were obtained from the limbus in a radial fashion incremented by 30°, forming a circular scan pattern. Volumetric flow was computed by integrating flow inside non-connected vessels throughout all 12 scans around the limbus. Results: At the GNR concentration of 0.7×1012 GNRs/mL, Doppler signal was present through the entire depth of the testing tube without substantial attenuation. A well-defined laminar flow profile was observed for Doppler images of GNRs flowing through the glass capillary tube. The Doppler OCT measured flow profile was not statistically different from the expected flow profile based upon an autoregressive moving average model, with an error of -0.025 to 0.037 mm/s (p = 0.6435). Cross-sectional slices demonstrated the ability to view anterior chamber outflow ex-vivo using GNR-enhanced Doppler OCT. Doppler volumetric flow measurements were comparable to flow recorded by the perfusion system. Conclusions: GNRs created a measureable Doppler signal within otherwise silent flow fields in OCT Doppler scans. Practical application of this technique was confirmed in a constant pressure ex-vivo aqueous humor outflow model in porcine eyes. © 2014 Wang et al
Observation of electron-antineutrino disappearance at Daya Bay
The Daya Bay Reactor Neutrino Experiment has measured a non-zero value for
the neutrino mixing angle with a significance of 5.2 standard
deviations. Antineutrinos from six 2.9 GW reactors were detected in
six antineutrino detectors deployed in two near (flux-weighted baseline 470 m
and 576 m) and one far (1648 m) underground experimental halls. With a 43,000
ton-GW_{\rm th}-day livetime exposure in 55 days, 10416 (80376) electron
antineutrino candidates were detected at the far hall (near halls). The ratio
of the observed to expected number of antineutrinos at the far hall is
. A rate-only analysis
finds in a
three-neutrino framework.Comment: 5 figures. Version to appear in Phys. Rev. Let
A side-by-side comparison of Daya Bay antineutrino detectors
The Daya Bay Reactor Neutrino Experiment is designed to determine precisely
the neutrino mixing angle with a sensitivity better than 0.01 in
the parameter sin at the 90% confidence level. To achieve this
goal, the collaboration will build eight functionally identical antineutrino
detectors. The first two detectors have been constructed, installed and
commissioned in Experimental Hall 1, with steady data-taking beginning
September 23, 2011. A comparison of the data collected over the subsequent
three months indicates that the detectors are functionally identical, and that
detector-related systematic uncertainties exceed requirements.Comment: 24 pages, 36 figure
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