1 research outputs found
Asymmetric Reductive Amination with Pinacolborane Catalyzed by Chiral SPINOL Borophosphates
The catalytic asymmetric reductive amination of ketones
with pinacolborane
employing chiral SPINOL-derived borophosphates as catalysts has been
realized. A series of chiral amine derivatives bearing multiple functional
groups were obtained in good to excellent yields and enantioselectivities
(up to 97% yield, 98% ee) under mild reaction conditions. Moreover,
the synthetic applicability of the established method has been demonstrated
by the asymmetric synthesis of (R)-Fendiline