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An evaluation of DIADEM assisted online form completion
The DIADEM project aims to develop a web-based application in the form of an Expert System (ES) to assist cognitively impaired older-adult users in the task of interacting with and completing online transactions. Having recently developed the first experimental version of the application, this study reports on the preliminary findings of user trials carried out in three European countries top evaluate this early version of the application. Of the 94 users that took part in the trials, 77 were identified as users that were likely to present with some degree of mild cognitive impairment, and thus were included in the analysis stage. The key findings of the study indicate that users of DIADEM assisted form filling seemed report comparatively high-levels of satisfaction, particularly when considered against what is considered a typical level of satisfaction for this user group. Furthermore, as a result of a statistical analysis, the application appears to provide significantly increased levels of assistance for users presenting with higher levels of cognitive impairments, and therefore achieves its goal of catering for this particular target user group
Transformational government and assistive web base technologies
Transformational government has been on the European agenda for several years. However, progress towards realising the full potential of ICT to transform public services for older adults with age related cognitive impairments has been very limited. Highlighting such limitations this paper demonstrates how assistive web base technologies can be developed to improve the public services for older adults with age related cognitive impairments. However the paper argues that these transformations can be obstructed if there is no strong leadership and political commitment from people at many levels in public sectors and governments
Dielectric and polarization experiments in high loss dielectrics: a word of caution
The recent quest for improved functional materials like high permittivity
dielectrics and/or multiferroics has triggered an intense wave of research.
Many materials have been checked for their dielectric permittivity or their
polarization state. In this report, we call for caution when samples are
simultaneously displaying insulating behavior and defect-related conductivity.
Many oxides containing mixed valent cations or oxygen vacancies fall in this
category. In such cases, most of standard experiments may result in effective
high dielectric permittivity which cannot be related to ferroelectric
polarization. Here we list few examples of possible discrepancies between
measured parameters and their expected microscopic origin
Building malaria out: improving health in the home.
Malaria prevalence has halved in endemic Africa since 2000, largely driven by the concerted international control effort. To achieve the new global targets for malaria control and elimination by 2030, and to sustain elimination once achieved, additional vector control interventions are urgently needed to supplement long-lasting insecticide-treated nets and indoor residual spraying, which both rely on effective insecticides for optimal protection. Improving housing and the built environment is a promising strategy to address this need, with an expanding body of evidence that simple modifications to reduce house entry by malaria vectors, such as closing eaves and screening doors and windows, can help protect residents from malaria. However, numerous questions remain unanswered, from basic science relating to the optimal design of house improvements through to their translation into operational use. The Malaria Journal thematic series on 'housing and malaria' collates articles that contribute to the evidence base on approaches for improving housing to reduce domestic malaria transmission
First-principles study of epitaxial strain in perovskites
Using an extension of a first-principles method developed by King-Smith and
Vanderbilt [Phys. Rev. B {\bf 49}, 5828 (1994)], we investigate the effects of
in-plane epitaxial strain on the ground-state structure and polarization of
eight perovskite oxides: BaTiO, SrTiO, CaTiO, KNbO, NaNbO,
PbTiO, PbZrO, and BaZrO. In addition, we investigate the effects of
a nonzero normal stress. The results are shown to be useful in predicting the
structure and polarization of perovskite oxide thin films and superlattices.Comment: 10 page
Conduction of topologically-protected charged ferroelectric domain walls
We report on the observation of nanoscale conduction at ferroelectric domain
walls in hexagonal HoMnO3 protected by the topology of multiferroic vortices
using in situ conductive atomic force microscopy, piezoresponse force
microscopy, and kelvin-probe force microscopy at low temperatures. In addition
to previously observed Schottky-like rectification at low bias [Phys. Rev.
Lett., 104, 217601 (2010)], conductance spectra reveal that negatively charged
tail-to-tail walls exhibit enhanced conduction at high forward bias, while
positively charged head-to-head walls exhibit suppressed conduction at high
reverse bias. Our results pave the way for understanding the semiconducting
properties of the domains and domain walls in small-gap ferroelectrics.Comment: 8 pages, 4 figure
Revised structural phase diagram of (Ba0.7Ca0.3TiO3)-(BaZr0.2Ti0.8O3)
The temperature-composition phase diagram of barium calcium titanate zirconate (x(Ba0.7Ca0.3TiO3)(1-x)(BaZr0.2Ti0.8O3); BCTZ) has been reinvestigated using high-resolution synchrotron x-ray powder diffraction. Contrary to previous reports of an unusual rhombohedral-tetragonal phase transition in this system, we have observed an intermediate orthorhombic phase, isostructural to that present in the parent phase, BaTiO3, and we identify the previously assigned T-R transition as a T-O transition. We also observe the O-R transition coalescing with the previously observed triple point, forming a phase convergence region. The implication of the orthorhombic phase in reconciling the exceptional piezoelectric properties with the surrounding phase diagram is discussed
Modelling frontotemporal dementia using patient-derived induced pluripotent stem cells
Frontotemporal dementia (FTD) describes a group of clinically heterogeneous conditions that frequently affect people under the age of 65 (1). There are multiple genetic causes of FTD, including coding or splice-site mutations in MAPT, GRN mutations that lead to haploinsufficiency of progranulin protein, and a hexanucleotide GGGGCC repeat expansion in C9ORF72. Pathologically, FTD is characterised by abnormal protein accumulations in neurons and glia. These aggregates can be composed of the microtubule-associated protein tau (observed in FTD with MAPT mutations), the DNA/RNA-binding protein TDP-43 (seen in FTD with mutations in GRN or C9ORF72 repeat expansions) or dipeptide proteins generated by repeat associated non-ATG translation of the C9ORF72 repeat expansion. There are currently no disease-modifying therapies for FTD and the availability of in vitro models that recapitulate pathologies in a disease-relevant cell type would accelerate the development of novel therapeutics. It is now possible to generate patient-specific stem cells through the reprogramming of somatic cells from a patient with a genotype/phenotype of interest into induced pluripotent stem cells (iPSCs). iPSCs can subsequently be differentiated into a plethora of cell types including neurons, astrocytes and microglia. Using this approach has allowed researchers to generate in vitro models of genetic FTD in human cell types that are largely inaccessible during life. In this review we explore the recent progress in the use of iPSCs to model FTD, and consider the merits, limitations and future prospects of this approach
Family-inclusive practice in a psychiatric intensive care unit
Aims and Method: The National Institute for Health and Care Excellence recommends involving the families of patients admitted to psychiatric hospital care, without specific guidance on how to do it. To improve family involvement in a National Health Service psychiatric intensive care unit, a relatives’ and carers’ clinic was set up. Fifty family members attended and completed questionnaires. Nine went on to take part in interviews, the results of which were analysed using thematic analysis.
Results: Families felt more informed and found the increased access to information useful. They felt that the process showed respect for them and their family member, and that their contribution was valued. Running throughout the interviews was the contrast with previous experiences; families reported feeling heard and understood and attributed this in part to timing and environment.
Clinical implications: The clinic was viewed positively by families and met the trust’s commitment to including carers, as well as national guidance which suggests it should be part of routine practice
Elastic effects of vacancies in strontium titanate: Short- and long-range strain fields, elastic dipole tensors, and chemical strain
We present a study of the local strain effects associated with vacancy
defects in strontium titanate and report the first calculations of elastic
dipole tensors and chemical strains for point defects in perovskites. The
combination of local and long-range results will enable determination of x-ray
scattering signatures that can be compared with experiments. We find that the
oxygen vacancy possesses a special property -- a highly anisotropic elastic
dipole tensor which almost vanishes upon averaging over all possible defect
orientations. Moreover, through direct comparison with experimental
measurements of chemical strain, we place constraints on the possible defects
present in oxygen-poor strontium titanate and introduce a conjecture regarding
the nature of the predominant defect in strontium-poor stoichiometries in
samples grown via pulsed laser deposition. Finally, during the review process,
we learned of recent experimental data, from strontium titanate films deposited
via molecular-beam epitaxy, that show good agreement with our calculated value
of the chemical strain associated with strontium vacancies.Comment: 14 pages, 11 figures, 4 table
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