Venstre om i Latinamerika

Latinamerika er uden tvivl trådt mod venstre i de senere år, men den generelle orientering i politikken er ikke entydig bortset fra det geopolitiske faktum, at de fleste sigter på større økonomisk og politisk uafhængighed af USA.&nbsp

Risk factors for cardiovascular disease and death in familial hypercholesterolemia

Background and aims: Familial hypercholesterolemia (FH) is a metabolic autosomal dominant disorder. It is characterised by elevated plasma total cholesterol and low density lipoprotein (LDL) cholesterol levels usually due to a genetic mutation in the LDL receptor gene and have therefore a higher risk of non-fatal or fatal coronary heart disease (CHD). Yet, there is a substantial variation between individuals with FH, even among FH subjects with the same genetic mutations, in susceptibility to CHD in terms of the age of onset and severity. The aim of this thesis was to increase the knowledge about which factors that may affect the onset of CHD in FH subjects. This is an important knowledge in order to determine how intense the treatment the various patients should be offered and how early treatment should be initiated. Subjects and methods: Two different studies were included in this thesis. The first study, a retrospective data collection study, characterised and compared clinical and biochemical parameters from the medical records of 71 FH subjects with early CHD event and 76 FH subjects with late or no CHD event. In addition, 14 deceased FH subjects with early CHD event and 14 deceased FH subjects with late or no CHD event were compared with each other and with the non-deceased FH groups. In the second study, a case-control study administered by the master student, clinical and biochemical parameters in a smaller group of FH subjects with more strict inclusion criteria than the first study were compared, with special regard to different coagulation factors, CRP and fibrinogen. The case-control study included 19 FH subjects with early CHD event, 15 FH subjects with late or no CHD event and 10 control subjects. All groups except from the control group were subdivided into gender. Results: FH subjects with early onset of CHD seems to have a more severe risk factor profile compared with FH subjects with late or no CHD event, even though they are more intensively medically treated. Female FH subjects seem to have a more severe risk factor profile in comparison with male FH subjects, suggesting that they are not well enough medically treated. However, in general, today’s lipid-lowering treatment seems to be more effective than the lipid-lowering treatment ten years ago, reducing the risk of fatal CHD in FH subjects. In our study, coagulation markers do not appear to play a determining role in susceptibility to CHD in FH subjects. Conclusion: Even though the treatment in FH subjects seems to have improved substantially, there is still a potential for improvement concerning reaching the treatment goals for blood lipid levels. Our results may also indicate that female FH subjects may need to be followed up more closely, and to be more extensively treated with lipid-lowering medication and combination medication. The contribution of lipoprotein (a) in particular but also supplementation with omega-3 fatty acids with regard to CHD risk and death in FH subjects should be examined to a greater extent

Hvad jeg i fremtiden vil huske at værdsætte ved on-site undervisning

Bidrag til DUT Tidskapse

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Kommentar til C.F. Binau og D. Salomonsen: “Redskab til analyse af integreret naturfag”, MONA 2019‑

Fidel Castros fravær udramatisk

Forhåbninger om at Cuba vil gå mere eller mindre i opløsning ved Fidel Castros bortgang, ser ud til at være skudt i sænk. Cubanerne har tilsyneladende forberedt sig grundigt.&nbsp

Tilstræbt og realiseret tværfaglighed i universitetsundervisning

Formålet med denne artikel er at give undervisere, som er involveret i tværfaglige uddannelser og undervisning, et grundlag for at kunne reflektere over og dis-kutere følgende: Hvad sker der med tværfagligheden i undervisningen, og hvor-dan hænger det sammen med de didaktiske valg i planlægning og udførelse? I artiklen sammenholder og præsenterer forfatterne først de mest udbredte beteg-nelser for tværfaglighed. Ved hjælp af en case bestående af et tværfagligt kursus, udbudt over flere gange og med forskelligt design, peger forfatterne herefter på nogle af de udfordringer, der er forbundet med at praktisere tværfaglig un-dervisning. Artiklen konkluderer, at centrale didaktiske overvejelser om stofud-vælgelse, arbejdsformer, eksamensformer samt deltagerforudsætninger og for-ventninger har afgørende betydning for realiseringen af den tilstræbte tværfag-lighed. This paper looks at questions relevant to the increasing number of teachers involved in interdisciplinary courses at university level. In particular it considers the link between the intended and the realized interdisciplinarity in teaching and how this is related to the didactical planning. Drawing on one case - an interdisciplinary master course offered three times and each time with a new design - the authors highlight some of the challenges associated with interdisciplinary teaching practice. Based on this case, the authors conclude that balancing teacher expectations with possible course outcomes, selecting and organizing course content as well as examination type, all have a massive impact on whether the intended interdisciplinarity is realized over the duration of the course