Distribution of sputum glucose concentration in 117 samples.

<p>Sputum glucose (SG) was much lower than previously reported, with 34% reading < 0.01 mM, and 55% of samples reading < 1.0 mM. The distribution of SG was highly skewed: the median concentration was 0.7 mM (IQR, 0–3.5 mM) versus the mean of 4.75 mM (SD 11.4 mM).</p

Comparisons of HbA_1c and SG by glucose tolerance.

<p>CFRD subjects had significantly higher HbA_1c than subjects with impaired (IGT) or normal glucose tolerance (NGT, left panel), while NGT subjects had significantly higher average sputum glucose than IGT or CFRD subjects (right panel). Diamonds are centered on each category’s mean and the vertical distance represents the 95% confidence interval.</p

Mean pulmonary function test results by glycemic control in CFRD.

<p>CFRD subjects with HbA_1c > 6.5% had significantly reduced average scores of forced expiratory volume in one second (FEV₁, left panel) and forced expiratory flow in the 25–75% of the patient’s exhaled volume (FEF25–75%, right panel) compared to CFRD subjects with HbA_1c ≤ 6.5%. Diamonds are centered on each category’s mean and the vertical distance represents the 95% confidence interval.</p

Study participant demographic information, n = 88.

<p>Study participant demographic information, n = 88.</p

Clinical parameters of CFRD subjects.

<p>Clinical parameters of CFRD subjects.</p