Senior Recital, Alexis Gruber, soprano

The presentation of this senior recital will fulfill in part the requirements for the Bachelor of Music degree in Performance. Alexis Gruber studies voice with Michelle Harmon-Gulick and receives vocal coaching from James Smith-Parham

Ingestion of amniotic fluid enhances the facilitative effect of VTA morphine on the onset of maternal behavior in virgin rats

Previous research has shown that injection of morphine into the ventral tegmental area(VTA) facilitates the onset of maternal behavior in virgin female rats, and injection of the opioid antagonist naltrexone into the VTA disrupts the onset of maternal behavior in parturient rats. Placentophagia – ingestion of placenta and amniotic fluid, usually at parturition – modifies central opioid processes. Ingestion of the active substance in placenta and amniotic fluid, Placental Opioid-Enhancing Factor (POEF), enhances the hypoalgesic effect of centrally administered morphine, and more specifically, enhances δ- and κ-opioid-receptor-\ud mediated hypoalgesia and attenuates μ-opioid-receptor-mediated hypoalgesia. POEF (in placenta or amniotic fluid) ingestion does not, by itself, produce hypoalgesia. In the\ud present study, we tested the hypothesis that ingestion of amniotic fluid enhances the facilitative effect of opioid activity (unilateral morphine injection) in the VTA on the rate of onset of maternal behavior. Virgin female Long-Evans rats were given one intra-VTA injection of morphine sulfate (0.0, 0.01, or 0.03 μg, in saline) and an orogastric infusion of 0.25 ml amniotic fluid or saline once each day of the first three days of the 10-day testing\ud period. Subjects were continuously exposed to foster pups that were replaced every 12 h; replacement of pups was followed by a 15-min observation period. Maternal behavior\ud latency was determined by the first of two consecutive tests wherein the subject displayed pup retrieval, pup licking in the nest, and crouching over all foster pups, during the 15-min observation. We confirmed the previous finding that the VTA injection, alone, of 0.03 μg morphine shortened the latency to show maternal behavior and that 0.0 μg and 0.01 μg morphine did not. Ingestion of amniotic fluid (and therefore POEF) facilitated the onset of\ud maternal behavior in rats receiving an intra-VTA microinjection of an otherwise subthreshold dose of morphine (0.01 μg)

Healthy Eating, Activity, Reinforcement, and Training (HEART): A Program for The Meeting Place Clubhouse

An assessment of HEART program which includes... - Program Design & Methodology - Social Marketing Plan - Evaluation Plan - Budgethttps://digital.sandiego.edu/npi-bpl-programdesign/1002/thumbnail.jp

Cover crops may exacerbate moisture limitations on South Texas dryland farms

Cover crops are a sustainable management tool for mediating weed pressure, reducing soil erosion, and enhancing soil organic carbon (C) and nitrogen (N) levels. Yet, adoption rates across water-limited farms in Texas remain low, especially among producers without irrigation access, due to concerns that cover crop use of soil moisture will negatively impact subsequent cash crop yields. This three-year cover crop trial in a rain-fed sorghum (Sorghum bicolor L.) farm in Lyford, Texas, trialed different cover crop mixes and seeding rates and confirmed that cover cropping leads to significant soil moisture deficits and cash crop failure when rainfall is low between cover crop termination and cash crop planting (\u3c30 \u3emm). In seasons one and three, moisture deficits contributed to significantly lower germination of post-cover crop sorghum compared to fallow control plots. In season two, increased precipitation during a longer moisture recharge period between cover crop termination and cash crop planting helped avoid sorghum yield drops. Length of recharge period, amount of rainfall, species selection, planting density, and termination method are major determinants of subsequent cash crop outcomes. Careful management can minimize some of the risks cover cropping poses to soil moisture, but without reliable rainfall at key points in the cropping cycle, cover cropping remains risky for farmers without irrigation access

Do Canine Companions Reduce College Stress?

Introduction Rates of mental health concerns among college students are rising. A recent World Health Organization Survey of ~14,000 students revealed clinically concerning scores on anxiety, depression and substance use disorder for 31% [2][3]. With these high levels of clinically concerning scores in college students, great amounts of stress are the result, which have been negatively correlated with greater feelings of loneliness and lower hedonic well-being (satisfaction in life), without proper social support [6][10]. We explored potential mental health benefits of canine companions in the college setting by collecting psychosocial measures from both dog-owners and non-dog-owners assessing their levels of anxiety, loneliness, and hedonic well-being. We also explored how the dimensions of dog cognition look when correlated with their owners\u27 scores on measures assessing their mental health. We assessed these levels of dog cognition through The Dognition Assessment, a web-based assessment for dog cognition and reasoning. Dognition measures levels of canine empathy, communication, as well as cunning (Figure 3). Dognition has been found to produce very similar results whether performed in a laboratory or in a home as citizen science [9]. • Hypothesis 1. Students living with dogs ( n = 20 ) will have lower anxiety and loneliness and higher satisfaction with life in comparison with a matched group of students not living with dogs ( n = 17). • Hypothesis 2. Among the student-canine dyads, canines with higher scores on empathy, communication, and cunning—measured via The Dognition Assessment—will have human partners with lower anxiety and loneliness and higher satisfaction with life

Hunters and Their Perceptions of Public Access: A View from Afield

Declining hunter participation threatens cultural traditions and public support for conservation, warranting examination of the forces behind the downward trajectory. Access to lands for hunting, an often-cited reason for non participation, may play a critical role in the retention and recruitment of hunters. Meeting the access needs of a diverse hunting constituency requires understanding how hunters use and perceive access opportunities, particularly public-access sites. Given that perceptions of access are entirely place based and degrade with time, traditional postseason survey methods may fail to adequately quantify the value of public access to the hunting constituency. To overcome the potential limitations of postseason surveys, we conducted on-site assessments of hunter perceptions of habitat quality, game abundance, ease of access, and crowding as well as whether the experience met the hunters’ expectations and their likelihood to return to hunt. Over 3 y, we interviewed 3,248 parties of which 71.5% were hunting. Most parties (65.9%) reported having no private access within the region of Nebraska where they were interviewed. Parties (67.6%) were largely limited to two or fewer hunters, most of whom were adult males (84.3%) who were, on average, 41.2 y old. The perception of public-access sites was generally positive, but 43.1% of parties indicated that game abundance was below average despite 59.2% of parties seeing game and 37.3% harvesting at least one animal. Similar to other explorations of hunter satisfaction, we found game abundance, and in particular harvest success, had the most consistent relationship with hunter perception of public access. By surveying multiple types of hunters across sites that encompass a range of social and ecological conditions, we gained a broader understanding of how hunters perceive public access in real time, which will help to inform future management decisions to foster and improve public-access programs

Phase 2B randomized study of nemolizumab in adults with moderate-to-severe atopic dermatitis and severe pruritus

Background: Nemolizumab targets the IL-31 receptor a subunit involved in atopic dermatitis (AD) pathogenesis. Objective: We sought to evaluate a new dosing strategy of nemolizumab in patients with AD. Methods: We performed a 24-week, randomized, double-blind, multicenter study of nemolizumab (10, 30, and 90 mg) subcutaneous injections every 4 weeks versus placebo, with topical corticosteroids in adults with moderate-to-severe AD, severe pruritus, and inadequate control with topical treatment (n 5 226). The Eczema Area and Severity Index (EASI), the peak pruritus (PP) numeric rating scale (NRS), and the Investigator’s Global Assessment (IGA) were assessed. Standard safety assessments were performed. Results: Nemolizumab improved EASI, IGA, and/or NRS-itch scores, with the 30-mg dose being most effective. Nemolizumab (30 mg) reduced EASI scores versus placebo at week 24 (268.8% vs 252.1%, P 5 .016); significant differences were observed by week 8 (P <_ .01). With significant improvement (P 5 .028) as early as week 4, IGA 0/1 rates were higher for 30 mg of nemolizumab versus placebo at week 16 (33.3% vs 12.3%, P 5 .008) but not week 24 because of an increased placebo/topical corticosteroid effect (36.8% vs 21.1%, P 5 .06). PP-NRS scores were improved for 30 mg of nemolizumab versus placebo at week 16 (268.6% vs 234.3%, P <.0001) and week 24 (267.3% vs 235.8%, P <.0001), with a difference by week 1 (P _4-point decrease) were greater for 30 mg of nemolizumab versus placebo at week 16 (P <_ .001) and week 24 (P <_ .01). Nemolizumab was safe and well tolerated. The most common adverse events were nasopharyngitis and upper respiratory tract infection. Conclusions: Nemolizumab resulted in rapid and sustained improvements in cutaneous signs of inflammation and pruritus in patients with AD, with maximal efficacy observed at 30 mg. Nemolizumab had an acceptable safety profile. (J Allergy Clin Immunol 2020;145:173-82.

The Eschatological Hope Scale: Construct Development and Measurement of Theistic Eschatological Hope

This study aimed to expand psychological research on hope by contributing a construct and scale to measure central dimensions of theistic eschatological hope derived from Christian scriptures. Eschatological hope was conceptualized as the anticipation that God will make all things new, raising people to everlasting life with God in joyful celebration, including people from every culture and nation, ending all personal pain and suffering, eliminating all societal evil and harm, and bringing reconciliation and healing to all of creation. We developed the Eschatological Hope Scale with three studies (N = 1,466). Exploratory and confirmatory factor analyses supported the single-factor structure of a 6-item scale with excellent internal consistency (Cronbach\u27s α \u3e .91) and good test-retest reliability. The Eschatological Hope Scale evidenced construct validity, showing significant non-redundant correlations with measures of temporal hope, religiosity, and spirituality. The Eschatological Hope Scale scores positively correlated with gratitude, forgivingness, and life hardship patience. Scores inversely correlated with depressed and anxious symptoms, negative religious coping, and negative attitudes toward God. Scores were not significantly correlated with extrinsic religiosity and searching for meaning. The Eschatological Hope Scale demonstrated incremental validity beyond other variables (hope and optimism, depression and anxiety, and religiosity) to predict three target variables: perceived presence of meaning in life, ultimate meaning, and flourishing. We offer the Eschatological Hope Scale as a gateway scale to catalyze further developments in measuring eschatological hope. We hope this work will facilitate research on the experience of living with ultimate hope across cultures and faith traditions, in seasons of suffering and celebration

An Avid Imitator

We present a case of disseminated cryptococcal disease, coexisting with and mimicking lymphoma. Determination of serum cryptococcal antigen should be considered for lymphopenic patients with hematologic malignancies, presenting with unexplained fever, and/or lymphadenopathy and/or pulmonary findings. Patients with hematologic malignancies treated with chemotherapy regimens are susceptible to diverse opportunistic infections. Therefore, in this patient population, it is often necessary to obtain a definitive pathologic diagnosis, to diagnose uncommon syndromes and guide management