23 research outputs found
Insights into APC/C: from cellular function to diseases and therapeutics
Get PDFAnaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets different substrates for ubiquitylation and therefore regulates a variety of cellular processes such as cell division, differentiation, genome stability, energy metabolism, cell death, autophagy as well as carcinogenesis. Activity of APC/C is principally governed by two WD-40 domain proteins, Cdc20 and Cdh1, in and beyond cell cycle. In the past decade, the results based on numerous biochemical, 3D structural, mouse genetic and small molecule inhibitor studies have largely attracted our attention into the emerging role of APC/C and its regulation in biological function, human diseases and potential therapeutics. This review will aim to summarize some recently reported insights into APC/C in regulating cellular function, connection of its dysfunction with human diseases and its implication of therapeutics
Comparison of Standard Coagulation Testing with Thromboelastometry Tests in Cardiac Surgery
No full textHeparin-like Polymer Surfaces: Control of Coagulation and Complement Activation by Insoluble Functionalized Polymers
No full textVariations in the ability of adsorbed fibrinogen to mediate platelet adhesion to polystyreneâbased materials: A multivariate statistical analysis of antibody binding to the platelet binding sites of fibrinogen
No full textFabrication and characterisation of an electrospun tubular 3D scaffold platform of poly(vinylidene fluoride-co-hexafluoropropylene) for small-diameter blood vessel application
No full textEffects of Aprotinin During Cardiopulmonary Bypass in Patients Treated with Acetylsalicylic Acid
No full textIn vivo assessment in sheep of thromboresistant materials by determination of platelet survival.
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