De vele gezichten van afstand in internationale handelsrelaties

Paintings, photographs and literary illustrations examine the intersections between depictions and realities of children in poverty from the late nineteenth and early twentieth centuries in the United States and Europe. Also on display are historical artifacts and books from the Gettysburg area that reveal Pennsylvania’s efforts towards reform during this age of industrialization.https://cupola.gettysburg.edu/pauperchildren/1000/thumbnail.jp

On the Specification of the Gravity Model of Trade: Zeros, Excess Zeros and Zero-Inflated Estimation

Conventional studies of bilateral trade patterns specify a log-normal gravity equation for empirical estimation. However, the log-normal gravity equation suffers from three problems: the bias created by the logarithmic transformation, the failure of the homoscedasticity assumption, and the way zero values are treated. These problems normally result in biased and inefficient estimates. Recently, the Poisson specification of the trade gravity model has received attention as an alternative to the log-normality assumption (Santos Silva and Tenreyro, 2006). However, the standard Poisson model is vulnerable for problems of overdispersion and excess zero flows. To overcome these problems, this paper considers modified Poisson fixed-effects estimations (negative binomial, zero-inflated). Extending the empirical model put forward by Santos Silva and Tenreyro (2006), we show how these techniques may provide viable alternatives to both the log-normal and standard Poisson specification of the gravity model of trade.international trade;gravity model;distance;modified Poisson models

S-100B protein and melanoma inhibitory activity protein in uveal melanoma screening. A comparison with liver function tests.

Item does not contain fulltextAIM: Our purpose was to determine whether S-100B or melanoma inhibitory activity (MIA) concentrations in the serum of patients with large uveal melanomas were better markers for the presentation of metastases than liver function tests. We also investigated whether increased marker levels were related to known clinical and histopathological prognostic parameters. METHODS: Total S-100B (A1B + BB) and MIA concentrations were measured in the sera from 104 patients with uveal melanoma prior to enucleation and in the sera from 50 healthy controls. Concentrations were also determined in the sera from 30 patients with known uveal melanoma metastases. Liaison Sangtec 100, an automated immunoluminometric assay measuring the total S-100B, and Roche MIA ELISA were used to quantify these proteins in serum. Results were compared with liver function tests [alkaline phosphatase, lactate dehydrogenase (LD), aspartate aminotransferase, alanine aminotransferase and gamma-glutamyl transpeptidase]. RESULTS: The mean S-100B and MIA concentrations were significantly higher in patients with metastases compared to melanoma patients without metastases. At the time of enucleation, S-100B and MIA were not prognostic for metastases in uveal melanoma, but S-100B and LD were the best tests to predict the occurrence of metastatic disease during the follow-up period. CONCLUSIONS: In our study, the S-100B and MIA serum concentrations were not correlated with any tested established prognostic parameter. S-100B and LD showed better performance in identifying melanoma metastases than gamma-glutamyl transpeptidase and MIA. A prospective follow-up study is needed to evaluate S-100B and MIA in identifying early micrometastasis in uveal melanoma

A Micro-Costing Framework for Circulating Tumor DNA Testing in Dutch Clinical Practice.

Circulating tumor DNA (ctDNA) is a promising new biomarker with multiple potential applications in cancer care. Estimating total cost of ctDNA testing is necessary for reimbursement and implementation, but challenging because of variations in workflow. We aimed to develop a micro-costing framework for consistent cost calculation of ctDNA testing. First, the foundation of the framework was built, based on the complete step-wise diagnostic workflow of ctDNA testing. Second, the costing method was set up, including costs for personnel, materials, equipment, overhead, and failures. Third, the framework was evaluated by experts and applied to six case studies, including PCR-, mass spectrometry-, and next-generation sequencing-based platforms, from three Dutch hospitals. The developed ctDNA micro-costing framework includes the diagnostic workflow from blood sample collection to diagnostic test result. The framework was developed from a Dutch perspective and takes testing volume into account. An open access tool is provided to allow for laboratory-specific calculations to explore the total costs of ctDNA testing specific workflow parameters matching the setting of interest. It also allows to straightforwardly assess the impact of alternative prices or assumptions on the cost per sample by simply varying the input parameters. The case studies showed a wide range of costs, from €168 to €7638 ($199 to$9124) per sample, and generated information. These costs are sensitive to the (coverage of) platform, setting, and testing volume

Designing a Second Generation of Open Data Platforms: Integrating Open Data and Social Media

Part 3: Policy and StakeholdersInternational audienceTwo important trends in government that are emerging in the recent years have been on one hand the exploitation of the Web 2.0 social media, supporting a more extensive interaction and collaboration with citizens, and on the other hand the opening of government data to the citizens through the Internet, in order to be used for scientific, commercial and political purposes. However, there has been limited attempt of integrating them. Using a design science approach a second generation of open government data (OGD) platforms has been developed, which offer to the users both the ‘classical’ first generation functionalities, and also a comprehensive set of additional novel Web 2.0 features. The latter aim to provide support to the users in order to generate value from ODG. They enable users to become ‘prosumers’, both producing and consuming data. These novel capabilities for performing various types of processing, information and knowledge exchange, and collaboration were found to be useful and valuable by users in a first evaluation