3,667 research outputs found
Modified Gravity Away from a CDM Background
Within the effective field theory approach to cosmic acceleration, the
background expansion can be specified separately from the gravitational
modifications. We explore the impact of modified gravity in a background
different from a cosmological constant plus cold dark matter (CDM) on
the stability and cosmological observables, including covariance between
gravity and expansion parameters. In No Slip Gravity the more general
background allows more gravitational freedom, including both positive and
negative Planck mass running. We examine the effects on cosmic structure
growth, as well as showing that a viable positive integrated Sachs-Wolfe effect
crosscorrelation easily arises from this modified gravity theory. Using current
data we constrain parameters with a Monte Carlo analysis, finding a maximum
running . We provide the modified {\tt hi\_class} code
publicly on GitHub, now enabling computation and inclusion of the redshift
space distortion observable as well as the No Slip Gravity
modifications.Comment: 14 pages, 13 figures. Matches published version in JCAP, LCDM
discussion adde
Cosmic Growth History and Expansion History
The cosmic expansion history tests the dynamics of the global evolution of
the universe and its energy density contents, while the cosmic growth history
tests the evolution of the inhomogeneous part of the energy density. Precision
comparison of the two histories can distinguish the nature of the physics
responsible for the accelerating cosmic expansion: an additional smooth
component - dark energy - or a modification of the gravitational field
equations. With the aid of a new fitting formula for linear perturbation growth
accurate to 0.05-0.2%, we separate out the growth dependence on the expansion
history and introduce a new growth index parameter \gamma that quantifies the
gravitational modification.Comment: 8 pages, 3 figures; minor changes to match version accepted to PR
Fingerprinting dark energy
Dark energy perturbations are normally either neglected or else included in a
purely numerical way, obscuring their dependence on underlying parameters like
the equation of state or the sound speed. However, while many different
explanations for the dark energy can have the same equation of state, they
usually differ in their perturbations so that these provide a fingerprint for
distinguishing between different models with the same equation of state. In
this paper we derive simple yet accurate approximations that are able to
characterize a specific class of models (encompassing most scalar-field models)
which is often generically called "dark energy". We then use the approximate
solutions to look at the impact of the dark energy perturbations on the dark
matter power spectrum and on the integrated Sachs-Wolfe effect in the cosmic
microwave background radiation.Comment: 11 pages, 5 figures, minor changes to match published versio
A forgotten facial nerve tumour: granular cell tumour of the parotid and its implications for treatment
We present a rare case of a facial nerve granular cell tumour in the right parotid gland, in a 10-year-old boy. A parotid or neurogenic tumour was suspected, based on magnetic resonance imaging. Intra-operatively, strong adhesions to surrounding structures were found, and a midfacial nerve branch had to be sacrificed for complete tumour removal. Recent reports verify that granular cell tumours arise from Schwann cells of peripheral nerve branches. The rarity of this tumour within the parotid gland, its origin from peripheral nerves, its sometimes misleading imaging characteristics, and its rare presentation with facial weakness and pain all have considerable implications on the surgical strategy and pre-operative counselling. Fine needle aspiration cytology may confirm the neurogenic origin of this lesion. When resecting the tumour, the surgeon must anticipate strong adherence to the facial nerve and be prepared to graft, or sacrifice, certain branches of this nerv
From incus bypass to malleostapedotomy: technical improvements and results
Abstract Objective: To assess results of malleostapedotomy using a Fisch Storz titanium piston with at least 10 months' follow up. Methods: Using a prospective database, the indications, surgical technique, and pre- and post-operative audiometric data for 60 patients undergoing malleostapedotomy between 2002 and 2010 were evaluated. Diagnoses and primary and revision surgeries were compared with reference to the literature. Results: Sixty endaural malleostapedotomies were performed, 28 as a primary intervention and 32 as revision surgery. In 68 per cent, the underlying pathology was otosclerosis. The most common reason for revision surgery (i.e. in 59 per cent) was prosthesis dysfunction. Overall, the mean air-bone gap (0.5-3kHz) for the primary intervention and revision surgery groups was 9.4 and 11.3dB, respectively; an air-bone gap of less than 20dB was obtained in 100 and 81 per cent of patients, respectively. There was no significant audiological difference between the primary and revision surgeries groups, and no deafness. Conclusion: Malleostapedotomy shows comparable results to standard incus-stapedotomy and may be preferable in the presented situation
Stellenwert der minimal-invasiven Chirurgie beim primären und sekundären Hyperparathyroidismus
BACKGROUND: The standard surgical approach to treat primary (pHPT) and secondary hyperparathyroidism (sHPT) used to be a cervicotomy with exploration of all four parathyroid glands. This access has been challenged recently by the introduction of minimally invasive techniques in order to achieve superior cosmesic results and to reduce theatre time. We analyzed the advantages and morbidities of these surgical aproaches. PATIENTS AND METHODS: Between 1997 and 2006 a total of 123 patients (109 with pHPT and 14 with sHPT) underwent parathyroidectomy at the ENT Department in Luzern. Ultrasonographic scanning was performed on 74 patients (68%), szintigraphy in 8 patients (7%) and both scanning methods in 27 patients (25%). 103 patients were available for follow-up. The indications for each technique were reviewed and outcome measures included serum Calcium and parathyroid hormone levels. RESULTS: Sensitivity for preoperative ultrasonographic and scintigraphic scanning was 67% and 65% for identification of the correct quadrant and 74% and 71% for identification of the correct side. A bilateral exploration was performed until June 2001 for all patients. Thereafter, a minimally invasive approach was chosen for patients with pHPT, whereas patients with sHPT still require bilateral exploration. Adequate preoperative localization was a prerequisite for a minimally invasive technique. Mean postoperative serum Kalzium levels were within the normal range, independently of the surgical technique and disease. Two patients developed hypercalcemia after an initially successful operation. CONCLUSIONS: Review of the literature confirms the shift from bilateral exploration towards minimally invasive techniques. The incidence of persistent or recurrent disease as well as the rate of complications seems comparable. Operation time for minimally invasive techniques is reduced in the hands of an experienced surgeon. However, proper preoperative localization of the diseased parathyroid gland is not always possible and the expenses of intraoperative parathyroid hormone measures do not lower the overall costs. Considerable experience and a multidisiplinary approach (endocrinologist, surgeon, pathologist) is required to adopt efficient minimally invasive techniques. As for sHPT, bilateral exploration remains the treatment of choice
Exploiting Cross Correlations and Joint Analyses
In this report, we present a wide variety of ways in which information from
multiple probes of dark energy may be combined to obtain additional information
not accessible when they are considered separately. Fundamentally, because all
major probes are affected by the underlying distribution of matter in the
regions studied, there exist covariances between them that can provide
information on cosmology. Combining multiple probes allows for more accurate
(less contaminated by systematics) and more precise (since there is
cosmological information encoded in cross-correlation statistics) measurements
of dark energy. The potential of cross-correlation methods is only beginning to
be realized. By bringing in information from other wavelengths, the
capabilities of the existing probes of dark energy can be enhanced and
systematic effects can be mitigated further. We present a mixture of work in
progress and suggestions for future scientific efforts. Given the scope of
future dark energy experiments, the greatest gains may only be realized with
more coordination and cooperation between multiple project teams; we recommend
that this interchange should begin sooner, rather than later, to maximize
scientific gains.Comment: Report from the "Dark Energy and CMB" working group for the American
Physical Society's Division of Particles and Fields long-term planning
exercise ("Snowmass"
Returning Integrated Genomic Risk and Clinical Recommendations: The eMERGE Study
The potential of artificial intelligence (AI) to reduce health care disparities and inequities is recognized, but it can also exacerbate these issues if not implemented in an equitable manner. This perspective identifies potential biases in each stage of the AI life cycle, including data collection, annotation, machine learning model development, evaluation, deployment, operationalization, monitoring, and feedback integration. To mitigate these biases, we suggest involving a diverse group of stakeholders, using human-centered AI principles. Human-centered AI can help ensure that AI systems are designed and used in a way that benefits patients and society, which can reduce health disparities and inequities. By recognizing and addressing biases at each stage of the AI life cycle, AI can achieve its potential in health car
Constraining Parity Violation in Gravity with Measurements of Neutron-Star Moments of Inertia
Neutron stars are sensitive laboratories for testing general relativity,
especially when considering deviations where velocities are relativistic and
gravitational fields are strong. One such deviation is described by dynamical,
Chern-Simons modified gravity, where the Einstein-Hilbert action is modified
through the addition of the gravitational parity-violating Pontryagin density
coupled to a field. This four-dimensional effective theory arises naturally
both in perturbative and non-perturbative string theory, loop quantum gravity,
and generic effective field theory expansions. We calculate here Chern-Simons
modifications to the properties and gravitational fields of slowly spinning
neutron stars. We find that the Chern-Simons correction affects only the
gravitomagnetic sector of the metric to leading order, thus introducing
modifications to the moment of inertia but not to the mass-radius relation. We
show that an observational determination of the moment of inertia to an
accuracy of 10%, as is expected from near-future observations of the double
pulsar, will place a constraint on the Chern-Simons coupling constant of
\xi^{1/4} < 5 km, which is at least three-orders of magnitude stronger than the
previous strongest bound.Comment: 14 pages, 6 figures, replaced with version accepted for publication
in Phys. Rev.
Quasar Proper Motions and Low-Frequency Gravitational Waves
We report observational upper limits on the mass-energy of the cosmological
gravitational-wave background, from limits on proper motions of quasars.
Gravitational waves with periods longer than the time span of observations
produce a simple pattern of apparent proper motions over the sky, composed
primarily of second-order transverse vector spherical harmonics. A fit of such
harmonics to measured motions yields a 95%-confidence limit on the mass-energy
of gravitational waves with frequencies <2e-9 Hz, of <0.11/h*h times the
closure density of the universe.Comment: 15 pages, 1 figure. Also available at
http://charm.physics.ucsb.edu:80/people/cgwinn/cgwinn_group/index.htm
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