The list of predicted target genes for miR-199a/199b/214 was refined by their expression in 19 normal tissue types extracted fromthe GNF database

<p><b>Copyright information:</b></p><p>Taken from "Characterization of microRNA expression profiles in normal human tissues"</p><p>http://www.biomedcentral.com/1471-2164/8/166</p><p>BMC Genomics 2007;8():166-166.</p><p>Published online 12 Jun 2007</p><p>PMCID:PMC1904203.</p><p></p> Blue bars on the right side of the heat map, genes with brain-specific expression; red bars, genes with PBMC-specific expression. The pseudocolor scale represents the gene expression level that has been transformed to the log2-based ratio to the average signal of all genes extracted

Unsupervised hierarchical clustering of normal human tissues based on the variation of miRNA abundance demonstrates similar patterns as shown in Figure 2

<p><b>Copyright information:</b></p><p>Taken from "Characterization of microRNA expression profiles in normal human tissues"</p><p>http://www.biomedcentral.com/1471-2164/8/166</p><p>BMC Genomics 2007;8():166-166.</p><p>Published online 12 Jun 2007</p><p>PMCID:PMC1904203.</p><p></p> Normalized Cfor each assay was transformed into ΔCagainst the average Cof all assays examined and clustered without centering the data. A pseudocolor scale outlines the Cvalues represented in the heat map. A detailed view of the clustering patterns of normal tissues is on the right

An enlarge view of the eight groups of most differentially expressed miRNAs

<p><b>Copyright information:</b></p><p>Taken from "Characterization of microRNA expression profiles in normal human tissues"</p><p>http://www.biomedcentral.com/1471-2164/8/166</p><p>BMC Genomics 2007;8():166-166.</p><p>Published online 12 Jun 2007</p><p>PMCID:PMC1904203.</p><p></p> The pseudocolor scale is the same as that in Figure 3

Unsupervised hierarchical clustering of the normal human tissues based on the variation of miRNA expression correlates with the anatomical locations and physiological functions of the tissues

<p><b>Copyright information:</b></p><p>Taken from "Characterization of microRNA expression profiles in normal human tissues"</p><p>http://www.biomedcentral.com/1471-2164/8/166</p><p>BMC Genomics 2007;8():166-166.</p><p>Published online 12 Jun 2007</p><p>PMCID:PMC1904203.</p><p></p> Normalized Cfor each assay was transformed into ΔCagainst the average Cof all assays examined and clustered after mean-centering the data for each miRNA but no centering was done for the tissues. A detailed view of the clustering patterns of normal tissues is on the right. The blue bar on the left side of the heat map represented the group of miRNAs primarily expressed in placenta, and the red bar indicated the miRNAs with significant increased expression in epithelial tissues including the gastrointestinal organs. A pseudocolor scale bar represented the fold change relative to the mean of the data for each miRNA

The abundance of miRNAs in all tissues represented by the estimated average copy numbers of all miRNAs examined, as well as by the average copy numbers of miRNAs in each of the eight most differentially expressed groups

<p><b>Copyright information:</b></p><p>Taken from "Characterization of microRNA expression profiles in normal human tissues"</p><p>http://www.biomedcentral.com/1471-2164/8/166</p><p>BMC Genomics 2007;8():166-166.</p><p>Published online 12 Jun 2007</p><p>PMCID:PMC1904203.</p><p></p> Y-axis is the estimated copy number per cell (assuming 30 pg of total RNA in each cell), and the order of normal tissues at the X-axis is arranged by the clustering patterns shown in the Figure 3

Summary of SEER Reported Characteristics for 169 patients with HCC.

<p>Summary of SEER Reported Characteristics for 169 patients with HCC.</p

Photomicrographs of HCC tissue specimens stained using anti-CKA antibody.

<p>Images magnified at 200×. A) Normal liver tissue demonstrates an absence of immunohistochemical staining. B) Corresponding HCC tumor specimen from the same patient demonstrates mild cytoplasmic staining of moderately-differentiated tumor cells. C) Moderately-differentiated HCC nested within an area of fibrosis. The tumor cells demonstrate moderate cytoplasmic and nuclear staining.</p

Distribution of HK2 Positive Tumors in Groups Defined by Clinicopathological Variables.

<p>Distribution of HK2 Positive Tumors in Groups Defined by Clinicopathological Variables.</p

Patterns of overall survival (OS) based on tumor immunohistochemical expression of CKA and HK2.

<p>Solid lines represent immunohistochemistry-positive cases while dotted lines represent immunohistochemistry-negative cases. A) OS was significantly worse for patients with CKA-positive tumors relative to patients with CKA-negative tumors (Log-Rank test p = 0.03). B) OS was also significantly worse for patients with HK2-positive tumors relative to patients with HK2-negative tumors (Log-Rank test p = 0.003). C) Among stage I and II HCC patients, OS was significantly worse for patients with CKA-positive tumors relative to patients with CKA-negative tumors (Log-rank p = 0.03). D) Among stage I and II HCC patients, OS was also significantly worse for patients with HK2-positive tumors relative to patients with HK2-negative tumors (Log-rank p = 0.02). E) Among patients with HK2-negative tumors, OS did not differ significantly on the basis of CKA expression (Log-Rank test p = 0.53). F) Among patients with HK2-positive tumors, OS was significantly worse in patients whose tumors were also CKA-positive (Log-Rank test p = 0.04). G) Among patients with CKA-negative tumors, OS did not differ significantly on the basis of HK2 expression (Log-Rank test p = 0.35). H) Among patients with CKA-positive tumors, OS was significantly worse in patients whose tumors were also HK2-positive (Log-Rank test p = 0.01).</p

Anaphalis sinica Hance var. viscosissima Kitam.

原著和名: クリヤマハハコ科名: キク科 = Compositae採集地: 栃木県 塩谷郡 栗山村 (下野 栗山村)採集日: 1969/8/31採集者: 萩庭丈壽整理番号: JH027401国立科学博物館整理番号: TNS-VS-97740