332 research outputs found
Modeling specific action potentials in the human atria based on a minimal reaction-diffusion model
We present an effective method to model empirical action potentials of
specific patients in the human atria based on the minimal model of
Bueno-Orovio, Cherry and Fenton adapted to atrial electrophysiology. In this
model, three ionic are currents introduced, where each of it is governed by a
characteristic time scale. By applying a nonlinear optimization procedure, a
best combination of the respective time scales is determined, which allows one
to reproduce specific action potentials with a given amplitude, width and
shape. Possible applications for supporting clinical diagnosis are pointed out.Comment: 16 pages, 8 figure
- …