Ekstrak Etanol Ubi Jalar Ungu untuk Mencegah Peningkatan pH Vagina setelah Ovariektomi Bilateral pada Tikus Wistar

AVaginal atrophy is one of the most common health problems in postmenopausal women. The disease is characterized by decreasing layers and maturation index of the vaginal epithelium and an increase in vaginal pH. A decrease in vaginal acidity will increase the susceptibility to infections since acidic pH protects the vagina from pathogens infection. The previous study has proven that phytoestrogens were effective to improve the microstructures of the vaginal, reduce urogenital complaints, and improve vaginal pH. The purple sweet potato (Ipomea batatas L.) which is cultivated in Bali was recognized for its high anthocyanin content and was reported to have phytoestrogen activity. The aim of the present study is to evaluate the effect of purple sweet potato on vaginal pH in an animal model of menopause. The randomized pre-test post-test control group design study was conducted using 36 bilateral ovariectomized female Wistar rats as an animal model of menopause. The animals were divided randomly into a control group (T0) which was given saline and a treatment group (T1) given an ethanolic extract of purple sweet potato 400 mg/day for 30 days. Vaginal pH was measured before treatment, every week during treatment, and after treatment. The result of the study showed that there was an increase in vaginal pH of the T0 on the 2nd and 3rd week, and after treatment (

Perbedaan Gambaran Histopatologi Granuloma Paru Mencit Setelah Diinfeksi Mycobacterium tuberculosis dan atau Intervensi Silika

The characteristics of lung tuberculosis is granuloma, which is consisted of lymphocytes andmacrophages that show the interaction between immune cells and M.tb. Granuloma is the organizationprocess which is depend on lymphocytes invasion, adhesion molecules and chemokine fasilitation. Silicosiswhich is caused by silica, can influence granuloma in the lung. The features of granuloma is variationdepend on the elicited agent and immune reaction. The main purpose of this study was to prove thehistopathology differences of mice lung granuloma caused by M.tb infection, silica intervention and bothin 3th and 7th weeks. It was 45 mice Balb-c strain, divided into 3 groups; P1 got M.tb infection with H37Rvstrain 105 perml,P2 got silica intervention with 60 micro litre and, P3 got both of M.tb infection and silica intervention. Termination of each group were held on 3 and 7 weeks of intervention, continued byhistopathology examination. In the histopathology feature, we done semi-quantitative prosedure to measurelung damage by using Dormans scores; perivasculitis, peribronchiolitis, alveolitis and granuloma. Oneway anova to analysis the differences of histopathologycal result among these groups (P< 0,05). Resultshowed the significant differences among these group. In the 3th weeks, we found mild lung damage werehappened in all groups with granuloma, without necrosic (P1 and P2). In the 7th weeks we found severe lungdamage in P3 with necrotic and fibrotic granuloma sign, with necrosis in P1, with fibrotic in P2. Weconcluded the worst lung damage happened in 7th weeks in group which are got M.tb infection and silicaintervention, with granuloma characterictic of necrosic and fibrotic

Pencegahan Gangguan Fungsi Ginjal Karena Stres Oksidatif pada Tikus Diabetes dengan Ubi Jalar Ungu

Recently, anthocyanins-rich food, is believed to prevent tissue damages due to oxidative stress. This studyaimed to investigate the protective effect of water extract of Balinese purple sweet potatoes which containhigh anthocyanins to the renal tissues of diabetic rats. A total of 30 adult male rats were divided into threegroups using randomized post-test only control group design, respectivelly. Animals in group 1 (diabeticgroup) were given streptozotocin 60 mg/kg; group 2 (diabetic+extract/ treatment group) at 3 days after theanimals were given streptozotocin they were given 4 mL per day of the extract for 50, group 3 (control group)animals were given placebo. At day 50 of the treatment, the blood and renal tissue superoxidase dismutase(SOD) and malondialdehyde (MDA), creatinin and blood urea nitrogen (BUN) level of all rats were measured.The data were analyzed using analysis of variance. The results showed a significant increase of blood andrenal tissues MDA and BUN level in group 1 (p&lt;0,05). In addition, a decrease of SOD and creatinin level(p&lt;0,05) were also seen in this group. In comparison to animals in group 2, the increase of blood MDA andBUN level as well the decrease of SOD and, creatinin level were significantly lower (p&lt;0,05). From thesefindings, it can be concluded that aqueous extract of Balinese purple sweet potato can prevent renalfunction disorders due to oxidative stress

PHARMACOTHERAPY ALOPECIA ANDROGENETIC IN MEN

Androgenetic alopecia is hair thinning due to the stimulation of hair follicles to androgens. Incidence in men is higher than in women, it is because men have a degree higher 5? reductase. This condition can cause both physical and psychological effects to the patient. Physical effects due to baldness cause hair loss as a function of protection against heat, cold and trauma. While psychologically can affect self-esteem and self-perception of the patient. Androgenetic alopecia in men influenced by the androgen dihydrotestosterone and genetic predisposition, although the physiology remains unclear. Modality in the management of androgenetic alopecia in males patients including pharmacotherapy, hair transplants and cosmetic approach. According to the Food and Drug Administration (FDA), there are two main drugs are safe and effective in the long term given to men with androgenetic alopecia are minoxidil and finasteride. Although the mechanism of action and route of administration are different, but both drugs have similar effectiveness in stopping the progression of androgenetic alopecia in men

POPULARITAS SITUS WEB PEMERINTAH DAERAH di PROVINSI BALI

Secara garis besar ada 3 jenis pengukuran yang dikenal sebagai pengukuran popularitas halaman web, yaitu:Popularitas Link, Popularitas Hit, dan Popularitas Trafik dimana dalam implementasinya popularitas linksangat erat kaitannya dengan cara kerja Search Engine Optimatization (SEO). Saat ini perkembangan dari situs webPemerintah Daerah memang meningkat pesat, namun baru dari segi kuantitas sedangkan sebagian besar pengelolasitus web Pemerintah Daerah belum mengoptimalkan efektifitas situs webnya. Penelitian ini bertujuan untukmelakukan pemeringkatan situs web e-Government Pemerintah Kabupaten dan Kota di Provinsi Bali berdasarkanpopularitas link free tools link popularitas checker yang dapat melihat dan mengukur kinerja situs web seperti Alexa,SEOQuake, dan Tools.Pingdom.Com. Hasil dari penelitian ini adalah pemeringkatan situs web PemerintahKabupaten dan Kota di Provinsi Bali berdasarkan traffik (Alexa) situs web Pemerintah Provinsi Bali (tertinggi)dan situs web Pemerintah Kabupaten Klungkung (terendah), density keyword (SEOQuake) situs web PemerintahKabupaten Gianyar (tertinggi) dan situs web Pemerintah Kabupaten Karangasem (terendah), dan time loading(Tools.Pingdom.com) situs web Pemerintah Kabupaten Tabanan (tertinggi) dan situs web Pemerintah KabupatenBuleleng (terendah)

THE ROLE OF ESTROGEN IN WOMEN WITH ANDROGENETIC ALOPECIA

Normal 0 false false false EN-US X-NONE X-NONE Hair loss may accured in both male and female population. Hair loss usually accured in Telogenic phase, meanwhile in Anagenic phase hair loss due to chemotherapy or radiation. Female pattern hair loss (FPHL) is regarded as hair fall type which is accured in women in common and known as female androgenetic alopecia. Almost 40%, 50 years old female shown hair fall sign, which is developed progressive fibrosing alopecia of central scalp, especially in frontal and parietal area. There are two common treatment for Female pattern Hair Loss are Minoxidil for topical use, and Fenesteride by oral. However, it has long been known that estrogens also profoundly alter hair follicle growth and cycling by binding to locally expressed high-affinity estrogen receptors (ERs), in turn increase anagenic phase and represed telogenic phase. /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} <![endif]--

Serum Hepcidin Level in Patients with Acute Lymphoblastic Leukemia (ALL) during The Treatment Phase: Their Effects on Erythropoisis Activity and Iron Reserves

Hepcidin levels increased significantly with increased of iron stores in early phase of acute leukemia patients when erithropoisis pressed by blast cells in bone marrow, then decreased significantly with acute leukemia remission. The study aimed to determine role of hepcidin in activity of erythropoisis and serum iron reserves in acute lymphoblastic leukemia (ALL) patients during phase of therapy. This study used an observational analytic design. Serum hepcidin examination used ELISA methods. Erythropoisis activity was determined by complete blood and reticulocyte percentage. Iron reserves was determined by serum iron and ferritin levels by ECLIA. Result shows a total of 48 patient subjects were divided into groups of induction, consolidation and maintenance phase with an average age of 6.81 years (induction), 9.7 years (consolidation) and 7.8 years (maintenance). In the normality test with Shapiro-Wilk data showed abnormal distribution (p <0.05). Analysis by the Kruskal-Wallis test showed there were differences between the three treatment phases in the examination of hemoglobin, reticulocytes, serum iron, ferritin and hepcidin (p <0.05). In statistical analysis with Spearman's rank correlation shows there is a significant correlation between hemoglobin with ferritin (r = -0.416, p = 0.003), hemoglobin with hepcidin (r = -0.305, p = 0.035), reticulocytes with hepcidin (r = -0.496), p = 0.000) and serum iron with hepcidin (r = -0.302, p = 0.037). We concluded that the higher levels of hepcidin indicate lower levels of hemoglobin, reticulocytes and serum iron in patients with acute lymphoblastic leukemia during treatment phase

Potensi Senyawa Fitokimia pada Tumbuhan dalam Menurunkan Kadar Glukosa Darah pada Diabetes Melitus: Potential of Phytochemical Compounds in Plants in Lowering Blood Glucose Levels in Diabetes

Diabetes melitus adalah gangguan metabolik kronis yang ditandai dengan hiperglikemia atau tingginya glukosa dalam darah karena gangguan dalam sekresi maupun respons terhadap hormon insulin. Menurut data dari International Diabetes Federation, prevalensi diabetes melitus di seluruh dunia sudah sangat tinggi, yaitu 537 juta pada tahun 2021. Akan tetapi, sudah ada berbagai obat alternatif alami yang dapat digunakan untuk menangani penyakit tersebut. Dalam beberapa penelitian, banyak tanaman yang sudah teruji khasiatnya sebagai obat antidiabetes alami karena kandungan fitokimianya. Studi literature review ini dilakukan dengan pencarian data melalui Google Scholar dan Science Direct dalam kurun  waktu 10 tahun terakhir (2013-2022). Dari 29 artikel yang sesuai diperoleh hasil bahwa beberapa kandungan fitokimia pada tumbuhan seperti alkaloid dengan kemampuannya memperbaiki sel beta pankreas, flavonoid sebagai astringen, saponin dengan kemampuannya menstimulasi sekresi insulin dari sel beta pankreas, dan tanin sebagai antioksidan alami berpotensi menurunkan glukosa darah pada diabetes melitus tipe 1 dan 2

Flavonoid dalam Penyembuhan Luka Bakar pada Kulit: Flavonoids in Healing Burns on the Skin

Burns can be caused by heat or other acute trauma, currently the number of cases is still high in Indonesia and the world. The advances of burns treatment are made through research on possible natural ingredients. Flavonoids are polyphenolic compounds that are most commonly found in plants and as well as possible in burn healing. The aims of this literature review are decribed burns, histological structure of skin, and the effectiveness of flavoinoids in burns healing. The method used in this literature review is by searching data through the Science Direct, PubMed, and Google chrome databases. The search results of 19 appropriate journals, it was found that the flavonoid compounds can heal burns through their ability to inhibit prostanoid biosynthesis, inhibition of phosphodiesterase, and various other important mechanisms. Keywords: burns, histological structure of skin, flavonoids, burns healing Abstrak Luka bakar dapat sebabkan oleh panas atau trauma akut lain, saat ini jumlah kasusnya masih tinggi di Indonesia maupun dunia. Kemajuan pengobatan luka bakar dilakukan melalui penelitian bahan alami yang berpotensi. Flavonoid adalah senyawa polifenolik yang paling banyak ditemukan pada tumbuh-tumbuhan serta berpotensi dalam penyembuhan luka bakar. Literature review ini bertujuan mengulas tentang luka bakar, struktur histologi kulit serta potensi flavonoid pada penyembuhan luka bakar. Metode yang digunakan dalam pembuatan literature review ini dengan pencarian data melalui database pada Science Direct, PubMed, dan Google chrome. Dari hasil pencarian ditemukan 19 jurnal yang sesuai, diperoleh hasil bahwa senyawa jenis flavonoid yang terkandung pada beberapa tumbuhan berpotensi menyembuhkan luka bakar melalui kemampuannya dalam penghambatan biosintesis prostanoid, penghambatan fosfodiesterase, serta berbagai mekanisme penting lainnya. Kata Kunci: luka bakar, struktur histologi kulit, flavonoid, penyembuhan luka baka