Functional Slicing-free Inverse Regression via Martingale Difference Divergence Operator

Functional sliced inverse regression (FSIR) is one of the most popular algorithms for functional sufficient dimension reduction (FSDR). However, the choice of slice scheme in FSIR is critical but challenging. In this paper, we propose a new method called functional slicing-free inverse regression (FSFIR) to estimate the central subspace in FSDR. FSFIR is based on the martingale difference divergence operator, which is a novel metric introduced to characterize the conditional mean independence of a functional predictor on a multivariate response. We also provide a specific convergence rate for the FSFIR estimator. Compared with existing functional sliced inverse regression methods, FSFIR does not require the selection of a slice number. Simulations demonstrate the efficiency and convenience of FSFIR

Bis(5-methyl-1-phenyl-1H-1,2,3-triazole-4-carb­oxy­lic acid) monohydrate

The crystal structure of the title compound, 2C10H9N3O2·H2O, synthesized from azido­benzene and ethyl acetyl­acetate, is stabilized by O—H⋯O and O—H⋯N hydrogen bonds

Text Mining-Based Patent Analysis for Automated Rule Checking in AEC

Automated rule checking (ARC), which is expected to promote the efficiency of the compliance checking process in the architecture, engineering, and construction (AEC) industry, is gaining increasing attention. Throwing light on the ARC application hotspots and forecasting its trends are useful to the related research and drive innovations. Therefore, this study takes the patents from the database of the Derwent Innovations Index database (DII) and China national knowledge infrastructure (CNKI) as data sources and then carried out a three-step analysis including (1) quantitative characteristics (i.e., annual distribution analysis) of patents, (2) identification of ARC topics using a latent Dirichlet allocation (LDA) and, (3) SNA-based co-occurrence analysis of ARC topics. The results show that the research hotspots and trends of Chinese and English patents are different. The contributions of this study have three aspects: (1) an approach to a comprehensive analysis of patents by integrating multiple text mining methods (i.e., SNA and LDA) is introduced ; (2) the application hotspots and development trends of ARC are reviewed based on patent analysis; and (3) a signpost for technological development and innovation of ARC is provided

Graph-Based Fusion of Imaging, Genetic and Clinical Data for Degenerative Disease Diagnosis

Graph learning methods have achieved noteworthy performance in disease diagnosis due to their ability to represent unstructured information such as inter-subject relationships. While it has been shown that imaging, genetic and clinical data are crucial for degenerative disease diagnosis, existing methods rarely consider how best to use their relationships. How best to utilize information from imaging, genetic and clinical data remains a challenging problem. This study proposes a novel graph-based fusion (GBF) approach to meet this challenge. To extract effective imaging-genetic features, we propose an imaging-genetic fusion module which uses an attention mechanism to obtain modality-specific and joint representations within and between imaging and genetic data. Then, considering the effectiveness of clinical information for diagnosing degenerative diseases, we propose a multi-graph fusion module to further fuse imaging-genetic and clinical features, which adopts a learnable graph construction strategy and a graph ensemble method. Experimental results on two benchmarks for degenerative disease diagnosis (Alzheimer's Disease Neuroimaging Initiative and Parkinson's Progression Markers Initiative) demonstrate its effectiveness compared to state-of-the-art graph-based methods. Our findings should help guide further development of graph-based models for dealing with imaging, genetic and clinical data

Perturbed autophagy intervenes systemic lupus erythematosus by active ingredients of traditional Chinese medicine

Systemic lupus erythematosus (SLE) is a common multisystem, multiorgan heterozygous autoimmune disease. The main pathological features of the disease are autoantibody production and immune complex deposition. Autophagy is an important mechanism to maintain cell homeostasis. Autophagy functional abnormalities lead to the accumulation of apoptosis and induce the autoantibodies that result in immune disorders. Therefore, improving autophagy may alleviate the development of SLE. For SLE, glucocorticoids or immunosuppressive agents are commonly used in clinical treatment, but long-term use of these drugs causes serious side effects in humans. Immunosuppressive agents are expensive. Traditional Chinese medicines (TCMs) are widely used for immune diseases due to their low toxicity and few side effects. Many recent studies found that TCM and its active ingredients affected the pathological development of SLE by regulating autophagy. This article explains how autophagy interferes with immune system homeostasis and participates in the occurrence and development of SLE. It also summarizes several studies on TCM-regulated autophagy intervention in SLE to generate new ideas for basic research, the development of novel medications, and the clinical treatment of SLE

A Multilayer Perceptron-based Fast Sunlight Assessment for the Conceptual Design of Residential Neighborhoods under Chinese Policy

In Chinese building codes, it is required that residential buildings receive a minimum number of hours of natural, direct sunlight on a specified winter day, which represents the worst sunlight condition in a year. This requirement is a prerequisite for obtaining a building permit during the conceptual design of a residential project. Thus, officially sanctioned software is usually used to assess the sunlight performance of buildings. These software programs predict sunlight hours based on repeated shading calculations, which is time-consuming. This paper proposed a multilayer perceptron-based method, a one-stage prediction approach, which outputs a shading time interval caused by the inputted cuboid-form building. The sunlight hours of a site can be obtained by calculating the union of the sunlight time intervals (complement of shading time interval) of all the buildings. Three numerical experiments, i.e., horizontal level and slope analysis, and simulation-based optimization are carried out; the results show that the method reduces the computation time to 1/84~1/50 with 96.5%~98% accuracies. A residential neighborhood layout planning plug-in for Rhino 7/Grasshopper is also developed based on the proposed model. This paper indicates that deep learning techniques can be adopted to accelerate sunlight hour simulations at the conceptual design phase