Using Twitter Data to Understand Public Perceptions of Approved versus Off-label Use for COVID-19-related Medications

Understanding public discourse on emergency use of unproven therapeutics is crucial for monitoring safe use and combating misinformation. We developed a natural language processing-based pipeline to comprehend public perceptions of and stances on coronavirus disease 2019 (COVID-19)-related drugs on Twitter over time. This retrospective study included 609,189 US-based tweets from January 29, 2020, to November 30, 2021, about four drugs that garnered significant public attention during the COVID-19 pandemic: (1) Hydroxychloroquine and Ivermectin, therapies with anecdotal evidence; and (2) Molnupiravir and Remdesivir, FDA-approved treatments for eligible patients. Time-trend analysis was employed to understand popularity trends and related events. Content and demographic analyses were conducted to explore potential rationales behind people's stances on each drug. Time-trend analysis indicated that Hydroxychloroquine and Ivermectin were discussed more than Molnupiravir and Remdesivir, particularly during COVID-19 surges. Hydroxychloroquine and Ivermectin discussions were highly politicized, related to conspiracy theories, hearsay, and celebrity influences. The distribution of stances between the two major US political parties was significantly different (P < .001); Republicans were more likely to support Hydroxychloroquine (55%) and Ivermectin (30%) than Democrats. People with healthcare backgrounds tended to oppose Hydroxychloroquine (7%) more than the general population, while the general population was more likely to support Ivermectin (14%). Our study found that social media users have varying perceptions and stances on off-label versus FDA-authorized drug use at different stages of COVID-19. This indicates that health systems, regulatory agencies, and policymakers should design tailored strategies to monitor and reduce misinformation to promote safe drug use.Comment: Full paper published in JAMI

Streamlining Social Media Information Retrieval for Public Health Research with Deep Learning

The utilization of social media in epidemic surveillance has been well established. Nonetheless, bias is often introduced when pre-defined lexicons are used to retrieve relevant corpus. This study introduces a framework aimed at curating extensive dictionaries of medical colloquialisms and Unified Medical Language System (UMLS) concepts. The framework comprises three modules: a BERT-based Named Entity Recognition (NER) model that identifies medical entities from social media content, a deep-learning powered normalization module that standardizes the extracted entities, and a semi-supervised clustering module that assigns the most probable UMLS concept to each standardized entity. We applied this framework to COVID-19-related tweets from February 1, 2020, to April 30, 2022, generating a symptom dictionary (available at https://github.com/ningkko/UMLS_colloquialism/) composed of 9,249 standardized entities mapped to 876 UMLS concepts and 38,175 colloquial expressions. This framework demonstrates encouraging potential in addressing the constraints of keyword matching information retrieval in social media-based public health research.Comment: Accepted to ICHI 2023 (The 11th IEEE International Conference on Healthcare Informatics) as a poster presentatio

Application of artificial intelligence in ophthalmic plastic surgery

The advancement of computers and data explosion have ushered in the third wave of artificial intelligence(AI). AI is an interdisciplinary field that encompasses new ideas, new theories, and new technologies, etc. AI has brought convenience to ophthalmology application and promoted its intelligent, precise, and minimally invasive development. At present, AI has been widely applied in various fields of ophthalmology, especially in oculoplastic surgery. AI has made rapid progress in image detection, facial recognition, etc., and its performance and accuracy have even surpassed humans in some aspects. This article reviews the relevant research and applications of AI in oculoplastic surgery, including ptosis, single eyelid, pouch, eyelid mass, and exophthalmos, and discusses the challenges and opportunities faced by AI in oculoplastic surgery, and provides prospects for its future development, aiming to provide new ideas for the development of AI in oculoplastic surgery

African bushpigs exhibit porous species boundaries and appeared in Madagascar concurrently with human arrival

Several African mammals exhibit a phylogeographic pattern where closely related taxa are split between West/Central and East/Southern Africa, but their evolutionary relationships and histories remain controversial. Bushpigs (Potamochoerus larvatus) and red river hogs (P. porcus) are recognised as separate species due to morphological distinctions, a perceived lack of interbreeding at contact, and putatively old divergence times, but historically, they were considered conspecific. Moreover, the presence of Malagasy bushpigs as the sole large terrestrial mammal shared with the African mainland raises intriguing questions about its origin and arrival in Madagascar. Analyses of 67 whole genomes revealed a genetic continuum between the two species, with putative signatures of historical gene flow, variable FST values, and a recent divergence time (&lt;500,000 years). Thus, our study challenges key arguments for splitting Potamochoerus into two species and suggests their speciation might be incomplete. Our findings also indicate that Malagasy bushpigs diverged from southern African populations and underwent a limited bottleneck 1000-5000 years ago, concurrent with human arrival in Madagascar. These results shed light on the evolutionary history of an iconic and widespread African mammal and provide insight into the longstanding biogeographic puzzle surrounding the bushpig's presence in Madagascar

Research on Technological Innovation as Seen through the Chinese Looking Glass

The rapid development of the Chinese economy during the 1990's has intensified research on technological innovation. Recent policy emphasis on innovation as a path to sustainable economic growth will only accelerate work on this important topic. The work by individuals and groups at various research institutes and universities has mainly been published in leading Chinese scholarly journals. In this paper, we develop a framework and do a substantive review of the literature to characterize the state of knowledge about technological innovation in China, with special emphasis on: 1) conceptual contributions, 2) empirical results, and 3) connections between innovation and performance