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Metastatic Renal Cell Carcinoma to the Sinonasal Cavity: A Case Series
Objectives: To describe the presentation, work-up, and management of patients with metastatic renal cell carcinoma (RCC) to the sinonasal cavity and skull base, and to describe our current treatment algorithm of endoscopic surgical resection followed by radiation therapy. Design: Retrospective review of two recent cases from our institution over a 1-year period, with a relevant review of the literature. Setting: A large regional tertiary care facility. Participants: Consecutive cases of RCC with metastases to the sinonasal cavity presenting to our institution. Main Outcome Measures: Preoperative and postoperative sinonasal outcome test (SNOT)-22 scores, duration of hospital stay, complications, and local disease control Results: Patients in this series underwent preoperative embolization followed by endoscopic resection without complication. Postoperatively they were treated with radiation therapy. They experienced improvement in their SNOT-22 scores and are currently free of local disease. Conclusion: Metastatic RCC to the sinonasal cavity can be safely treated with preoperative embolization followed by endoscopic surgical resection and radiation therapy, which can result in improvement in sinonasal quality of life and is a potential adjunct for local control of disease
Multimodal MRI Neuroimaging Biomarkers for Cognitive Normal Adults, Amnestic Mild Cognitive Impairment, and Alzheimer's Disease
Multimodal magnetic resonance imaging (MRI) techniques have been developed to noninvasively measure structural, metabolic, hemodynamic and functional changes of the brain. These advantages have made MRI an important tool to investigate neurodegenerative disorders, including diagnosis, disease progression monitoring, and treatment efficacy evaluation. This paper discusses recent findings of the multimodal MRI in the context of surrogate biomarkers for identifying the risk for AD in normal cognitive (NC) adults, brain anatomical and functional alterations in amnestic mild cognitive impairment (aMCI), and Alzheimer's disease (AD) patients. Further developments of these techniques and the establishment of promising neuroimaging biomarkers will enhance our ability to diagnose aMCI and AD in their early stages and improve the assessment of therapeutic efficacy in these diseases in future clinical trials
Cryogenic mechanical loss of a single-crystalline GaP coating layer for precision measurement applications
The first direct observations of gravitational waves have been made by the Advanced LIGO detectors.
However, the quest to improve the sensitivities of these detectors remains, and epitaxially grown single-crystal
coatings show considerable promise as alternatives to the ion-beam sputtered amorphous mirror
coatings typically used in these detectors and other such precision optical measurements. The mechanical
loss of a 1 μm thick single-crystalline gallium phosphide (GaP) coating, incorporating a buffer layer region
necessary for the growth of high quality epitaxial coatings, has been investigated over a broad range of
frequencies and with fine temperature resolution. It is shown that at 20 K the mechanical loss of GaP is a
factor of 40 less than an undoped tantala film heat-treated to 600 °C and is comparable to the loss of a
multilayer GaP/AlGaP coating. This is shown to translate into possible reductions in coating thermal noise
of a factor of 2 at 120 K and 5 at 20 K over the current best IBS coatings (alternating stacks of silica and
titania-doped tantala). There is also evidence of a thermally activated dissipation process between 50 and
70 K
Review of Bats and SARS
TOC Summary: The discovery of SARS-like coronaviruses in horseshoe bats highlights the possibility of future outbreaks caused by different coronaviruses of bat origin
EXTENSIBLE DATABASE FRAMEWORK FOR MANAGEMENT OF UNSTRUCTURED AND SEMI-STRUCTURED DOCUMENTS
Method and system for querying a collection of Unstructured or semi-structured documents to identify presence of, and provide context and/or content for, keywords and/or keyphrases. The documents are analyzed and assigned a node structure, including an ordered sequence of mutually exclusive node segments or strings. Each node has an associated set of at least four, five or six attributes with node information and can represent a format marker or text, with the last node in any node segment usually being a text node. A keyword (or keyphrase) is specified. and the last node in each node segment is searched for a match with the keyword. When a match is found at a query node, or at a node determined with reference to a query node, the system displays the context andor the content of the query node
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