4,934 research outputs found
Phase Transformations in Binary Colloidal Monolayers
Phase transformations can be difficult to characterize at the microscopic
level due to the inability to directly observe individual atomic motions. Model
colloidal systems, by contrast, permit the direct observation of individual
particle dynamics and of collective rearrangements, which allows for real-space
characterization of phase transitions. Here, we study a quasi-two-dimensional,
binary colloidal alloy that exhibits liquid-solid and solid-solid phase
transitions, focusing on the kinetics of a diffusionless transformation between
two crystal phases. Experiments are conducted on a monolayer of magnetic and
nonmagnetic spheres suspended in a thin layer of ferrofluid and exposed to a
tunable magnetic field. A theoretical model of hard spheres with point dipoles
at their centers is used to guide the choice of experimental parameters and
characterize the underlying materials physics. When the applied field is normal
to the fluid layer, a checkerboard crystal forms; when the angle between the
field and the normal is sufficiently large, a striped crystal assembles. As the
field is slowly tilted away from the normal, we find that the transformation
pathway between the two phases depends strongly on crystal orientation, field
strength, and degree of confinement of the monolayer. In some cases, the
pathway occurs by smooth magnetostrictive shear, while in others it involves
the sudden formation of martensitic plates.Comment: 13 pages, 7 figures. Soft Matter Latex template was used. Published
online in Soft Matter, 201
Star Formation in Emission-Line Galaxies Between Redshifts of 0.8 and 1.6
Optical spectra of 14 emission-line galaxies representative of the 1999
NICMOS parallel grism Ha survey of McCarthy et al. are presented. Of the 14, 9
have emission lines confirming the redshifts found in the grism survey. The
higher resolution of our optical spectra improves the redshift accuracy by a
factor of 5. The [O II]/Ha values of our sample are found to be more than two
times lower than expected from Jansen et al. This [O II]/Ha ratio discrepancy
is most likely explained by additional reddening in our Ha-selected sample [on
average, as much as an extra E(B-V) = 0.6], as well as to a possible stronger
dependence of the [O II]/Ha ratio on galaxy luminosity than is found in local
galaxies. The result is that star formation rates (SFRs) calculated from [O
II]3727 emission, uncorrected for extinction, are found to be on average 4 +/-
2 times lower than the SFRs calculated from Ha emission. Classification of
emission-line galaxies as starburst or Seyfert galaxies based on comparison of
the ratios [O II]/Hb and [Ne III]3869/Hb is discussed. New Seyfert 1
diagnostics using the Ha line luminosity, H-band absolute magnitude, and Ha
equivalent widths are also presented. One galaxy is classified as a Seyfert 1
based on its broad emission lines, implying a comoving number density for
Seyfert 1s of 2.5{+5.9, -2.1} times 10^{-5} Mpc^{-3}. This commoving number
density is a factor of 2.4{+5.5,-2.0} times higher than estimated by other
surveys.Comment: 51 pages, 18 figures; Accepted for publication in the Astrophysical
Journal; Revised version with minor changes and an additional reference which
gives further support to our conclusion
The roles of aldehyde dehydrogenases (ALDHs) in the PDH bypass of Arabidopsis
<p>Abstract</p> <p>Background</p> <p>Eukaryotic aldehyde dehydrogenases (ALDHs, EC 1.2.1), which oxidize aldehydes into carboxylic acids, have been classified into more than 20 families. In mammals, Family 2 ALDHs detoxify acetaldehyde. It has been hypothesized that plant Family 2 ALDHs oxidize acetaldehyde generated via ethanolic fermentation, producing acetate for acetyl-CoA biosynthesis via acetyl-CoA synthetase (ACS), similar to the yeast pathway termed the "pyruvate dehydrogenase (PDH) bypass". Evidence for this pathway in plants has been obtained from pollen.</p> <p>Results</p> <p>To test for the presence of the PDH bypass in the sporophytic tissue of plants, Arabidopsis plants homozygous for mutant alleles of all three Family 2 ALDH genes were fed with <sup>14</sup>C-ethanol along with wild type controls. Comparisons of the incorporation rates of <sup>14</sup>C-ethanol into fatty acids in mutants and wild type controls provided direct evidence for the presence of the PDH bypass in sporophytic tissue. Among the three Family 2 ALDHs, one of the two mitochondrial ALDHs (ALDH2B4) appears to be the primary contributor to this pathway. Surprisingly, single, double and triple ALDH mutants of Arabidopsis did not exhibit detectable phenotypes, even though a Family 2 ALDH gene is required for normal anther development in maize.</p> <p>Conclusion</p> <p>The PDH bypass is active in sporophytic tissue of plants. Blocking this pathway via triple ALDH mutants does not uncover obvious visible phenotypes.</p
The 11 March 2011 Tohoku tsunami wavefront mapping across offshore Southern California
The 11 March 2011 (M_w = 9.0) Tohoku tsunami was recorded by a temporary array of seafloor pressure gauges deployed off the coast of Southern California, demonstrating how dense array data can illustrate and empirically validate predictions of linear tsunami wave propagation characteristics. A noise cross-correlation method was used to first correct for the pressure gauge instrument phase response. Phase and group travel times were then measured for the first arrival in the pressure gauge tsunami waveforms filtered in narrow bands around 30 periods between 200 and 3000 s. For each period, phase velocities were estimated across the pressure gauge array based on the phase travel time gradient using eikonal tomography. Clear correlation was observed between the phase velocity and long-wavelength bathymetry variations where fast and slow velocities occurred for deep and shallow water regions, respectively. In particular, velocity gradients are pronounced at the Patton Escarpment and near island plateaus due to the abrupt bathymetry change. In the deep open ocean area, clear phase velocity dispersion is observed. Comparison with numerically calculated tsunami waveforms validates the approach and provides an independent measure of the finite-frequency effect on phase velocities at long periods
Preterm Premature Rupture of Membranes in Human Immunodeficiency Virus-Infected Women: A Novel Case Series
Objective. To evaluate the management and outcomes of a series of human immunodeficiency virus-(HIV-) infected women whose pregnancies were complicated by preterm premature rupture of membranes (PPROM). Study design. We conducted a retrospective chart review of all women with confirmed HIV infection who had a pregnancy complicated by PPROM remote from term. PPROM remote from term was defined as rupture of membranes prior to 32-week gestation. Collective cases from two centers (Hennepin County Medical Center and The University of Alabama at Birmingham) were reviewed and data on management and outcomes were abstracted. Results. Of the HIV-positive women, we identified 291 pregnancies having occurred in the study interval from two institutions. Of these pregnancies, 7 (2.4%) developed PPROM remote from term with subsequent delivery from 25- to 32-week gestation. Vertical HIV transmission was noted in 2 of 6 children whose long-term followup status was confirmed (33%) of these cases. However, both of these cases occurred in women with either no antepartum/intrapartum antiviral therapy or where only zidovudine monotherapy was used. Importantly, in spite of expectant management, no cases of vertical HIV transmission occurred in women who were receiving either multidrug or highly active antiviral therapy (HAART) at the time of PPROM and who had a cesarean delivery in cases where the predelivery viral load > 1000 copies/mL. Conclusion. Our limited observations raise the question as to whether in the current era of multidrug therapy immediate delivery should be undertaken in HIV+ pregnancies complicated by PPROM at an early gestational age. This case series further suggests that in those pregnancies that lend themselves to expectant management, such a strategy may be considered appropriate
A phase 2, multicenter, open-label study of anti-LAG-3 ieramilimab in combination with anti-PD-1 spartalizumab in patients with advanced solid malignancies
Efficacy; LAG-3 inhibitor; IeramilimabEficàcia; Inhibidor de LAG-3; IeramilimabEficacia; Inhibidor de LAG-3; IeramilimabIeramilimab, a humanized anti-LAG-3 monoclonal antibody, was well tolerated in combination with the anti-PD-1 antibody spartalizumab in a phase 1 study. This phase 2 study aimed to further investigate the efficacy and safety of combination treatment in patients with selected advanced (locally advanced or metastatic) solid malignancies. Eligible patients with non-small cell lung cancer (NSCLC), melanoma, renal cell carcinoma (RCC), mesothelioma, and triple-negative breast cancer (TNBC) were grouped depending on prior anti-PD-1/L1 therapy (anti-PD-1/L1 naive or anti-PD-1/L1 pretreated). Patients received ieramilimab (400 mg) followed by spartalizumab (300 mg) every 3 weeks. The primary endpoint was objective response rate (ORR), along with safety, pharmacokinetics, and biomarker assessments. Of 235 patients, 142 were naive to anti-PD-1/L1 and 93 were pretreated with anti-PD-1/L1 antibodies. Durable responses (>24 months) were seen across all indications for patients naive to anti-PD-1/L1 and in melanoma and RCC patients pretreated with anti-PD1/L1. The most frequent study drug-related AEs were pruritus (15.5%), fatigue (10.6%), and rash (10.6%) in patients naive to anti-PD-1/L1 and fatigue (18.3%), rash (14.0%), and nausea (10.8%) in anti-PD-1/L1 pretreated patients. Biomarker assessment indicated higher expression of T-cell-inflamed gene signature at baseline among responding patients. Response to treatment was durable (>24 months) in some patients across all enrolled indications, and safety findings were in accordance with previous and current studies exploring LAG-3/PD-1 blockade
Very Red and Extremely Red Galaxies in the Fields of z ~ 1.5 Radio-Loud Quasars
We previously identified an excess of mostly red galaxies around 31 RLQs at
z=1-2. These fields have an ERO (extremely red object, R-K>6) density 2.7 times
higher than the field. Assuming the EROs are passively evolved galaxies at the
quasar redshifts, they have characteristic luminosities of only ~L^*. We also
present new observations of four z~1.54 RLQ fields: (1) Wide-field J & Ks data
confirm an Abell richness ~2 excess within 140" of Q0835+580 but an excess only
within 50" of Q1126+101. (2) In 3 fields we present deep narrow-band redshifted
H-alpha observations. We detect five candidate galaxies at the quasar
redshifts, a surface density 2.5x higher than the field. (3) SCUBA sub-mm
observations of 3 fields detect 2 quasars and 2 galaxies with SEDs best fit as
highly reddened galaxies at the quasar z. (4) H-band adaptive optics (AO)
imaging is used to estimate redshifts for 2 red, bulge-dominated galaxies using
the Kormendy relation. Both have structural redshifts foreground to the quasar,
but these are not confirmed by photometric redshifts, possibly because their
optical photometry is corrupted by scattered light from the AO guidestar. (5)
We use quantitative SED fits to constrain the photometric redshifts z_ph for
some galaxies. Most galaxies near Q0835+580 are consistent with being at its
redshift, including a candidate very old passively evolving galaxy. Many very &
extremely red objects have z_ph z_q, and dust reddening is required to fit most
of them, including many objects whose fits also require relatively old stellar
populations. Large reddenings of E(B-V)~0.6 are required to fit four J-K
selected EROs, though all but one of them have best-fit z_ph>z_q. These objects
may represent a population of dusty high-z galaxies underrepresented in
optically selected samples. (Abridged)Comment: Missing object 1126.424 added to Table 4; title changed to save
people the apparent trouble of reading the abstract. 38 pages, 16 figures, 2
in color; all-PostScript figure version available from
http://astro.princeton.edu/~pathall/tp3.ps.g
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