Fabrication of a microresonator-fiber assembly maintaining a high-quality factor by CO2 laser welding

We demonstrate fabrication of a microtoroid resonator of a high-quality (high-Q) factor using femtosecond laser three-dimensional (3D) micromachining. A fiber taper is reliably assembled to the microtoroid using CO2 laser welding. Specifically, we achieve a high Q-factor of 2.12*10^6 in the microresonator-fiber assembly by optimizing the contact position between the fiber taper and the microtoroid.Comment: 7 pages, 5 figure

Twin-field quantum key distribution without optical frequency dissemination

Twin-field (TF) quantum key distribution (QKD) has rapidly risen as the most viable solution to long-distance secure fibre communication thanks to its fundamentally repeater-like rate-loss scaling. However, its implementation complexity, if not successfully addressed, could impede or even prevent its advance into real-world. To satisfy its requirement for twin-field coherence, all present setups adopted essentially a gigantic, resource-inefficient interferometer structure that lacks scalability that mature QKD systems provide with simplex quantum links. Here we introduce a novel technique that can stabilise an open channel without using a closed interferometer and has general applicability to phase-sensitive quantum communications. Using locally generated frequency combs to establish mutual coherence, we develop a simple and versatile TF-QKD setup that does not need service fibre and can operate over links of 100 km asymmetry. We confirm the setup's repeater-like behaviour and obtain a finite-size rate of 0.32 bit/s at a distance of 615.6 km.Comment: 14 pages, 7 figure

Dynamic responses analysis of submerged floating tunnel under impact load

Submerged floating tunnel (SFT) may be subjected to sudden impact loads such as submarine and shipwreck. Besides the local damage caused by impact, the overall transient dynamic response may also affect its driving safety. Based on the dynamic impact finite element software, the full-length model and the locally truncated accurate model with solid element of the SFT are established respectively. By applying different spring stiffness constraints on the boundary of the truncated model, its first three modes are consistent with the full-length model, thus their dynamic characteristics are basically the same. The truncated model is further used to simulate the impact of a massive object on the SFT under different impact velocities, impact mass, impact angles and impact positions. The velocity and mass of the impact object have positive influences on the peak contact force, the displacement amplitude of the tube and the length of the damaged area. When the impact angle is perpendicular to the SFT tube, the contact force, displacement amplitude and the damaged area are the largest. The change of the impact position has little effect on the contact force and the damage area, but it will affect the distribution of displacement amplitude

Experimental Quantum Communication Overcomes the Rate-loss Limit without Global Phase Tracking

Secure key rate (SKR) of point-point quantum key distribution (QKD) is fundamentally bounded by the rate-loss limit. Recent breakthrough of twin-field (TF) QKD can overcome this limit and enables long distance quantum communication, but its implementation necessitates complex global phase tracking and requires strong phase references which not only add to noise but also reduce the duty cycle for quantum transmission. Here, we resolve these shortcomings, and importantly achieve even higher SKRs than TF-QKD, via implementing an innovative but simpler measurement-device-independent QKD which realizes repeater-like communication through asynchronous coincidence pairing. Over 413 and 508 km optical fibers, we achieve finite-size SKRs of 590.61 and 42.64 bit/s, which are respectively 1.80 and 4.08 times of their corresponding absolute rate limits. Significantly, the SKR at 306 km exceeds 5 kbit/s and meets the bitrate requirement for live one-time-pad encryption of voice communication. Our work will bring forward economical and efficient intercity quantum-secure networks.Comment: 29 pages, 10 figures, 3 table

The usefulness of serial ultrasound in thyroid mucosa-associated lymphoid tissue lymphoma

BackgroundMucosa-associated lymphoid tissue (MALT) lymphoma is an extranodal lymphoma with an indolent natural course. The thyroid gland is an uncommon site of involvement. We aimed to investigate serial ultrasound features and the disease progression during the clinical course of thyroid MALT lymphoma.MethodsWe searched our hospital’s pathology database (5,418 patients with thyroid malignancy) between January 2000 and July 2022. The medical records and serial ultrasounds of 11 patients with 12 thyroid MALT lymphoma foci were analyzed retrospectively.ResultsAn enlarging neck mass, dyspnea, B symptoms, and neck lymphadenopathy were seen at diagnosis in 9 (9/11, 81.8%), 3 (3/11, 27.3%), 2 (2/11, 18.2%), and 9 (9/11, 81.8%) cases, respectively. Eleven cases were concomitant Hashimoto thyroiditis. Common ultrasound features included bilateral or unilateral asymmetric goiter or large, solid, and very hypoechoic nodules (11/12, 91.7%) interspersed with linear, reticular hyperechoic, and enhanced posterior echoes (11/12, 91.7%), and neck lymph node involvement (10/11, 90.9%). The Thyroid Imaging and Reporting Data System (TIRADS) categories showed higher diagnostic accuracy (11/12, 91.7%) than real-time ultrasound (2/12, 16.7%) in evaluating thyroid lesions for recommendation of fine-needle aspiration (FNA). Serial ultrasound showed self-limiting changes in three cases, relapse in three cases after subtotal thyroidectomy and chemotherapy, large cell transformation (LCT) in one case after left lobectomy, partial remission in one case, and complete remission after chemo/radiation in four cases; progression to enlarged thyroid nodules occurred in three cases without treatment, with no obvious change observed after diagnosis. Three patients died during follow-up.ConclusionOn sonograms, solid large thyroid nodules or goiter with very hypoechoic and enhanced posterior echoes in the setting of Hashimoto thyroiditis should raise suspicion for MALT lymphoma. TIRADS categories can improve the ultrasound diagnostic efficacy for malignancy. Serial ultrasound examinations demonstrated self-limiting and indolent natures of thyroid MALT lymphoma

Comparative Genomic Analysis of Functional Genomics of Lactiplantibacillus plantarum ST

In this study, the functional genomic characteristics of Lactiplantibilus plantarum ST were analyzed. Comparative genomic analysis was performed on the whole genome sequences of L. plantarum ST and the type strain L. plantarum ATCC 14197T as well as those of 152 L. plantarum strains published in the NCBI GenBank. A phylogenetic tree was constructed based on 1 262 core genes of these 154 L. plantarum strains, and the genetic distance between ST and the intestinal isolate BCC9546 was found to be the closest. The isolates originated from milk and meat products were concentrated in the upper part and the lower part of the second branch, respectively, and they were different due to different sources and could be aggregated. Meanwhile, Drosophila isolates showed a significant aggregation trend. Functional annotation analysis suggested that the ST genome contained genes related to the phosphotransferase system (PTS) as a major carbohydrate transport system. Genes related to the immune regulatory pathway were also annotated. There were many genes related to the hydrolysis or rearrangement of glycosidic bonds, but no virulence factors or antibiotics resistance genes found in ST. Compared with the other L. plantarum isolates, ST carried the unique functional gene ecfT related to energy transport function. In addition, ST had functional genes involved in the synthesis of the quorum-sensing signaling molecule AI-2, glutathione, and adhesion molecules. The results of API 50 CHL carbohydrate metabolism showed that L. plantarum ST could utilize a wide range of carbon sources and metabolize 29 carbon sources including monosaccharides, glycosides, disaccharides and polysaccharides. This study provides a genetic basis for the development and utilization of L. plantarum ST as a safe probiotic strain

SATB2 shows different profiles between appendiceal adenocarcinomas ex goblet cell carcinoids and appendiceal/colorectal conventional adenocarcinomas: An immunohistochemical study with comparison to CDX2

Background: Special AT-rich sequence-binding protein 2 (SATB2) is a novel marker for colorectal adenocarcinomas but little is known about its expression in appendiceal adenocarcinomas. We aim to investigate SATB2 in these tumors and colorectal adenocarcinomas with comparison to CDX2. Methods: Immunohistochemical stains for SATB2 and CDX2 were performed in 49 appendiceal adenocarcinomas (23 conventional, 26 adenocarcinoma ex goblet cell carcinoids (AdexGCCs)) and 57 colorectal adenocarcinomas. Their expression was correlated with tumor differentiation and growth patterns. Results: SATB2 staining was positive in 26/26 (100%) appendiceal AdexGCCs and 15/23 (65%) appendiceal conventional adenocarcinomas (P = 0.001). Their mean percentage of SATB2-positive cells was 93% and 34%, respectively (P \u3c 0.0001). CDX2 staining was seen in 26/26 (100%) AdexGCCs and 22/23 (96%) appendiceal conventional adenocarcinomas (P = 0.4694). SATB2 and CDX2 showed similar staining in AdexGCCs but CDX2 labeled more tumor cells than SATB2 in conventional adenocarcinomas (mean 84% vs. 34%, P \u3c 0.0001). SATB2 and CDX2 staining was seen in 82% (47/57) and 96% (55/57) colorectal adenocarcinomas, respectively (P = 0.01). The mean percentage of cells positive for SATB2 and CDX2 was 48% and 91%, respectively (P \u3c 0.00001). Decreased SATB2 immunoreactivity was associated with non-glandular differentiation particularly signet ring cells in colorectal (P = 0.001) and appendiceal conventional adenocarcinomas (P = 0.04) but not in appendiceal AdexGCCs. Conclusions: SATB2 is a highly sensitive marker for appendiceal AdexGCCs with similar sensitivity as CDX2. In colorectal and appendiceal conventional adenocarcinomas, SATB2 is not as sensitive as CDX2 and its immunoreactivity is dependent on tumor differentiation

Relationship between occupational stress and job burnout among rural-to-urban migrant workers in Dongguan, China: a cross-sectional study

Objectives: In China, there have been an increasing number of migrant workers from rural to urban areas, and migrant workers have the highest incidence of occupational diseases. However, few studies have examined the impact of occupational stress on job burnout in these migrant workers. This study aimed to investigate the relationship between occupational stress and job burnout among migrant workers. Design: This study used a cross-sectional survey. Setting: This investigation was conducted in Dongguan city, Guangdong Province, China. Participants: 3806 migrant workers, aged 18–60 years, were randomly selected using multistage sampling procedures. Primary and secondary outcome measures: Multistage sampling procedures were used to examine demographic characteristics, behaviour customs and jobrelated data. Hierarchical linear regression and logistic regression models were constructed to explore the relationship between occupational stress and burnout. Results: Demographics, behaviour customs and jobrelated characteristics significantly affected on burnout. After adjusting for the control variable, a high level of emotional exhaustion was associated with high role overload, high role insufficiency, high role boundary, high physical environment, high psychological strain, high physical strain, low role ambiguity, low responsibility and low vocational strain. A high level of depersonalisation was associated with high role overload, high role ambiguity, high role boundary, high interpersonal strain, high recreation, low physical environment and low social support. A low level of personal accomplishment was associated with high role boundary, high role insufficiency, low responsibility, low social support, low physical environment, low self-care and low interpersonal strain. Compared to the personal resources, the job strain and personal strain were more likely to explain the burnout of rural-to-urban migrant workers in our study. Conclusions: The migrant workers have increased job burnouts in relation to occupational stress. Relieving occupational stress and maintaining an appropriate quantity and quality of work could be important measures for preventing job burnout among these workers