Generalized parton distributions of gluon in proton: a light-front quantization approach

We solve for the gluon generalized parton distributions (GPDs) inside the proton, focusing specifically on leading twist chiral-even GPDs. We obtain and employ the light-front wavefunctions (LFWFs) of the proton from a light-front quantized Hamiltonian with Quantum Chromodynamics input using basis light-front quantization (BLFQ). Our investigation incorporates the valence Fock sector with three constituent quarks and an additional Fock sector, encompassing three quarks and a dynamical gluon. We examine the GPDs within impact parameter space and evaluate the $x$-dependence of the transverse square radius. We find that the transverse size of the gluon at lower-$x$ is larger than that of the quark, while it exhibits opposite behavior at large-$x$. Using the proton spin sum rule, we also determine the relative contributions of quarks and the gluon to the total angular momentum of the proton.Comment: 10 pages, 4 figure

Fluorescent Aerogels Based on Chemical Crosslinking between Nanocellulose and Carbon Dots for Optical Sensor

Generally produced by solvent sublimation via freeze-drying or critical point drying treatment, nanocellulose-based aerogels have attracted considerable interest in offering the features such as sustainability, available surface reactivity, lightweight, high porosity, and specific surface area. This study presents a novel strategy for the preparation of fluorescent aerogels based on covalent linkage between the natural skeleton of a cellulose nanofibril (CNF) and a fluorescent carbon dot (CD). The maximum CD grafting content on the CNF-based aerogel was 113 mg g–1, providing bright blue fluorescence under ultraviolet radiation with a high fluorescence quantum yield of 26.2%. Besides improved mechanical properties with a 360% increase in compression strength, the covalently bonded CD nanoparticle further serves as a structural stabilizer to endow the characteristic of shape recovery in water for the fabricated fluorescent aerogel. Finally, this aerogel displays high sensitivity and selection on the recognition of NOx and aldehyde species, which is studied for the detection of glutaraldehyde at ultralow concentrations (ppm) in water. Using the innovation of an organic solvent-free route and avoiding the toxic crosslinking reagents or fluorescent sources, the CNF/CD-based fluorescent aerogel developed in this study is a promising functional material for potential optical sensing application

High glucose promotes benign prostatic hyperplasia by downregulating PDK4 expression

Abstract As men age, a growing number develop benign prostatic hyperplasia (BPH). According to previous research, diabetes may be a risk factor. Pyruvate dehydrogenase kinase 4 (PDK4) is closely related to glucose metabolism and plays a role in the onset and progression of numerous illnesses. This study aimed to determine the direct effects of high glucose environment on prostate epithelial cells, in particular by altering PDK4 expression levels. In this investigation, normal prostatic epithelial cells (RWPE-1) and human benign prostatic hyperplasia epithelial cells (BPH-1) were treated with 50 mM glucose to show the alteration of high glucose in prostate cells. PDK4-target siRNA, PDK4-expression plasmid were used to investigate the effects of PDK4. Rosiglitazone (RG), a PPARγ agonist, with the potential to up-regulate PDK4 expression was also used for treating prostate cells. The expression of PDK4 in human prostate samples was also analyzed. The effects of high glucose therapy on BPH-1 and RWPE-1 cells were demonstrated to enhance proliferation, epithelial-mesenchymal transition (EMT), suppress apoptosis, and down-regulate PDK4 expression. Additionally, diabetes-related BPH patients had reduced PDK4 expression. Following the application of PDK4-target siRNA, a comparable outcome was seen. The PDK4-expression plasmid therapy, however, produced the opposite results. RG with the ability to elevate PDK4 expression might be used to treat BPH. Changes in the metabolism of lipids and glucose may be the cause of these consequences. These findings showed that high glucose treatment might facilitate BPH development, and may be related to the down-regulation of PDK4. PDK4 might be a potential therapeutic target of BPH

Generalized parton distributions of gluon in proton: A light-front quantization approach

We solve for the gluon generalized parton distributions (GPDs) inside the proton at zero skewness, focusing specifically on leading twist chiral-even GPDs. We obtain and employ the light-front wavefunctions (LFWFs) of the proton from a light-front quantized Hamiltonian with Quantum Chromodynamics input using basis light-front quantization (BLFQ). Our investigation incorporates the valence Fock sector with three constituent quarks and an additional Fock sector, encompassing three quarks and a dynamical gluon. We examine the GPDs within impact parameter space and evaluate the x-dependence of the transverse square radius. We find that the transverse size of the gluon at lower-x is larger than that of the quark, while it exhibits opposite behavior at large-x. Using the proton spin sum rule, we also determine the relative contributions of quarks and the gluon to the total angular momentum of the proton

YAP1 Recognizes Inflammatory and Mechanical Cues to Exacerbate Benign Prostatic Hyperplasia via Promoting Cell Survival and Fibrosis

Abstract Chronic prostatic inflammation promotes cell survival and fibrosis, leading to benign prostatic hyperplasia (BPH) with aggravated urinary symptoms. It is investigated whether yes‐associated protein 1 (YAP1), an organ size controller and mechanical transductor, is implicated in inflammation‐induced BPH. The correlation between YAP1 expression and fibrosis in human and rat BPH specimens is analyzed. Furthermore, the effects of YAP1 activation on prostatic cell survival and fibrosis, as well as the underlying mechanism, are also studied. As a result, total and nuclear YAP1 expression, along with downstream genes are significantly upregulated in inflammation‐associated human and rat specimens. There is a significant positive correlation between YAP1 expression and the severity of fibrosis or clinical performance. YAP1 silencing suppresses cell survival by decreasing cell proliferation and increasing apoptosis, and alleviates fibrosis by reversing epithelial‐mesenchymal transition (EMT) and extracellular matrix (ECM) deposition in prostatic BPH‐1 and WPMY‐1 cells. Mechanistically, inflammatory stimulus and rigid matrix stiffness synergistically activate the RhoA/ROCK1 pathway to provoke cytoskeleton remodeling, thereby promoting YAP1 activation to exacerbate BPH development. Overall, inflammation‐triggered mechanical stiffness reinforcement activates the RhoA/ROCK1/F‐actin/YAP1 axis, thereby promoting prostatic cell survival and fibrosis to accelerate BPH progression