Bob Reich Oral History Interview

https://scholarlycommons.pacific.edu/raymond-college/1069/thumbnail.jp

A Study of the Cognition-Action Gap in Knowledge Management

We investigated three types of volitional control mechanisms that may impact people’s knowledge management (KM) practices. Our results show that, when employing KM, people do not always perform in a manner consis- tent with their beliefs concerning attitudes and intentions. This cognition-behavior inconsistency can be ex- plained by volitional control mechanisms. Specifically, both perceived self-efficacy (Bandura 1997) and action control (Kuhl and Bechmänn 1985) play a role in motivating individuals to share and use knowledge, while perceived behavioral control does not. In addition, action/state orientation moderates a person’s enactment of subjective norm and self-efficacy beliefs into intentions just as it moderates enactment of perceived behavioral control belief into behaviors. These results have important theoretical and managerial implication

Impact of a Community-Controlled Adult Literacy Campaign on Crime and Justice Outcomes in Remote Australian Aboriginal Communities

Using qualitative self-reported and observational evidence combined with a quantitative breakdown of linked administrative justice system data, this before-and-after study demonstrates the beneficial impacts of a First Nations community-controlled adult literacy campaign in six rural and remote communities in New South Wales, Australia. The most significant quantitative finding is a 50% reduction in reported serious offences in a sample of 162 campaign participants. Qualitative data from interviews found  an increased use of legal assistance services following the campaign.. These findings are contextualised through the lived experiences and perceptions of First Nations campaign staff and participants, community leaders and government and non-government agency personnel

Noninvasive Imaging beyond the Diffraction Limit of 3D Dynamics in Thickly Fluorescent Specimens

SummaryOptical imaging of the dynamics of living specimens involves tradeoffs between spatial resolution, temporal resolution, and phototoxicity, made more difficult in three dimensions. Here, however, we report that rapid three-dimensional (3D) dynamics can be studied beyond the diffraction limit in thick or densely fluorescent living specimens over many time points by combining ultrathin planar illumination produced by scanned Bessel beams with super-resolution structured illumination microscopy. We demonstrate in vivo karyotyping of chromosomes during mitosis and identify different dynamics for the actin cytoskeleton at the dorsal and ventral surfaces of fibroblasts. Compared to spinning disk confocal microscopy, we demonstrate substantially reduced photodamage when imaging rapid morphological changes in D. discoideum cells, as well as improved contrast and resolution at depth within developing C. elegans embryos. Bessel beam structured plane illumination thus promises new insights into complex biological phenomena that require 4D subcellular spatiotemporal detail in either a single or multicellular context

Balancing continuous, integrated, and batch processing

We are building a new disposable manufacturing system to support the development and manufacturing of mAb and mAb-related products. We have made choices that are different than many others in the field of continuous and integrated processing. These choices avoid many misperceptions about continuous processing, are consistent with a staged approach to implementation, and facilitate manufacturing in either large-scale disposable or stainless manufacturing facilities. We have avoided the use of long-term steady-state perfusion. This mode of perfusion suffers from long development times, long manufacturing duration, extended Process Performance Qualification, large media consumption and perceived concerns about product quality variability and contamination. The system uses a short duration (\u3c15 days) non-steady state perfusion with perfusion rates as low as 0.3 bioreactor volumes per day. On-line UPLC is used to monitor product titer and quality. As a consequence of non-steady state perfusion operation, the integrated downstream is capable of handling day to day variability of 0.5g/L/day to 4g/L/day. The downstream avoids the use of SMB or PCC; rather, it integrates two batch chromatographic steps, a continuous virus inactivation step, and avoids in-process pooling. The product is stored after the second chromatography step for the duration of the batch. When the batch is complete, the pooled product is batched through a virus reduction filter and UFDF to make the bulk drug substance. Running these last two processes on the entire product pool at once allows an easy definition of a batch, without worry about pooling drug substance with different product quality profiles. The result is an integrated, semi-continuous manufacturing process that mitigates many of the concerns felt by the batch-processing community

Mutant subsumption graphs

Mutation testing researchers have long known that\ud many generated mutants are not needed. This paper develops a\ud graph model to describe redundancy among mutations. We define\ud “true” subsumption, a relation that practicing test engineers\ud would like to have, but cannot due to issues of computability.\ud We also define dynamic subsumption and static subsumption as\ud approximations of “true” subsumption. We explore the properties\ud of the approximate subsumption relations in the context of a small\ud example. We suggest possible uses for subsumption graphs.FAPESP (número processo 2012/16950-5

Effects of genuine dimension-six Higgs operators

We systematically discuss the consequences of genuine dimension-six Higgs operators. These operators are not subject to stringent constraints from electroweak precision data. However, they can modify the couplings of the Higgs boson to electroweak gauge bosons and, in particular, the Higgs self-interactions. We study the sensitivity to which those couplings can be probed at future \ee linear colliders in the sub-TeV and in the multi-TeV range. We find that for $\sqrt s=500$ GeV with a luminosity of 1 ab$^{-1}$ the anomalous $WWH$ and $ZZH$ couplings may be probed to about the 0.01 level, and the anomalous $HHH$ coupling to about the 0.1 level.Comment: 21 pages, 17 figures; typos corrected and references adde