Radio emission from dark matter annihilation in the Large Magellanic Cloud

The Large Magellanic Cloud, at only 50 kpc away from us and known to be dark matter dominated, is clearly an interesting place where to search for dark matter annihilation signals. In this paper, we estimate the synchrotron emission due to WIMP annihilation in the halo of the LMC at two radio frequencies, 1.4 and 4.8 GHz, and compare it to the observed emission, in order to impose constraints in the WIMP mass vs. annihilation cross section plane. We use available Faraday rotation data from background sources to estimate the magnitude of the magnetic field in different regions of the LMC's disc, where we calculate the radio signal due to dark matter annihilation. We account for the e+ e- energy losses due to synchrotron, Inverse Compton Scattering and bremsstrahlung, using the observed hydrogen and dust temperature distribution on the LMC to estimate their efficiency. The extensive use of observations, allied with conservative choices adopted in all the steps of the calculation, allow us to obtain very realistic constraints.Comment: 9 pages, 7 figure

Anatomically reduced fixation should always be considered when treating B and C proximal epiphyseal humeral fractures

Background Proximal humeral fractures are commonly observed in elderly patients. Management of these injuries is controversial. Literature comparing locking plate fixation, arthroplasty, and conservative treatments show no clear advantages for any of these management strategies. Thus far, no study has considered anatomically reduced fractures obtained after locking plate treatment. To clarify the best surgical procedure in middle-aged patients, we considered outcomes and major complications leading to surgical revision following an anatomically reduced fracture fixed with locking plate and reverse shoulder arthroplasty (RSA) in the treatment of type B/C fractures in patients between 50 and 75 years of age. Methods This is a retrospective study including 59 patients between 50 and 75 years of age with type B/C proximal humeral fracture treated with RSA or with locking plate fixation (resulting in an anatomical reduction) between January 2010 and December 2018. Preoperative radiographs and computed tomography (CT) were evaluated in all patients. Clinical and radiologic follow-up was performed using range of motion (ROM), the Constant-Murley Score (CMS), the Oxford Shoulder Score (OSS), the Simple Shoulder Test (SST), the Subjective Shoulder Value (SSV), and visual analog scale (VAS). Major complications were considered. Results In the plate fixation group, ROM, CMS, SST, and VAS were higher than in the RSA group. Lower complication rates compared with the literature were observed in both groups. Anatomically reduced fracture fixed with plate and screw could outperform RSA in terms of outcome. In second-level centers where traumatology is performed by surgeons with great expertise in upper limb trauma, the choice between plate fixation and reverse arthroplasty should be made during surgery. Conclusion Anatomically reduced fractures showed better outcomes compared with RSA in type B/C fractures. Surgeons should always try to perform a reduction of the fracture in order to understand if a plate fixation could be feasible. If it is impossible to perform an anatomical reduction, we suggest to consider RSA. This is a retrospective observational study

Valproic Acid, a Histone Deacetylase Inhibitor, in Combination with Paclitaxel for Anaplastic Thyroid Cancer: Results of a Multicenter Randomized Controlled Phase II/III Trial

Anaplastic thyroid cancer (ATC) has a median survival less than 5 months and, to date, no effective therapy exists. Taxanes have recently been stated as the main drug treatment for ATC, and the histone deacetylase inhibitor valproic acid efficiently potentiates the effects of paclitaxel in vitro. Based on these data, this trial assessed the efficacy and safety of the combination of paclitaxel and valproic acid for the treatment of ATC. This was a randomized, controlled phase II/III trial, performed on 25 ATC patients across 5 centers in northwest Italy. The experimental arm received the combination of paclitaxel (80 mg/m2/weekly) and valproic acid (1,000 mg/day); the control arm received paclitaxel alone. Overall survival and disease progression, evaluated in terms of progression-free survival, were the primary outcomes. The secondary outcome was the pharmacokinetics of paclitaxel. The coadministration of valproic acid did not influence the pharmacokinetics of paclitaxel. Neither median survival nor median time to progression was statistically different in the two arms. Median survival of operated-on patients was significantly better than that of patients who were not operated on. The present trial demonstrates that the addition of valproic acid to paclitaxel has no effect on overall survival and disease progression of ATC patients. This trial is registered with EudraCT 2008-005221-11

Simone Weil: uno stile di pensiero

Per capire il pensiero di Simone Weil, bisogna capire non soltanto ciò che essa dice, ma il punto di vista da cui lo dice. Simone Weil non si limita a pensare l’etica, perché è una pensatrice tragica dell’etica, che parte fondamentalmente dal vissuto e non da altre teorie. Simone Weil pensa a partire dalla catastrofe. Ciò illumina un profilo specifico nello statuto della filosofia. Ma nel pensiero della Weil è individuabile anche un equivoco, riguardante il modo con cui essa ha equivocato sul significato della “persona”, pur condividendone la sostanza del valore. Mettere ordine nei significati di “personale” e di “impersonale” serve a chiarificare non solo il lessico, ma i significati stessi di cui quel lessico parla