Comparison of fitness scores of genes important during phosphorus-limited growth and phosphate starvation and seventeen other previously tested stresses or growth conditions.

<p>Genes with the potential to inform about responses specific to phosphate-limited conditions are listed along the y-axis on the right. Experimental conditions are labeled on top, along the x-axis. The color bar in the top right corner shows colors assigned to the numerical values of fitness scores: negative scores representing fitness defects are blue, positive scores representing fitness benefits are yellow, and fitness-neutral scores are black. The first seven columns starting from the left show scores measured and reported in the current study, the adjacent seventeen columns show scores measured by previous studies and stored in the <a href="http://microbesonline.org" target="_blank">microbesonline.org</a> database. The names of genes with predicted direct roles in phosphorus homeostasis are labeled by light blue-colored boxes. The names of genes with predicted or confirmed direct roles in the biosynthesis of the cell envelope are labeled by rose-colored boxes. The names of genes with predicted roles in transport are labeled by yellow-colored boxes, those encoding the Hmc complex are labeled by green-colored boxes.</p

Quality of survival assessment in European childhood brain tumour trials, for children aged 5 years and over

IntroductionThere is increasing recognition of the long-term sequelae of brain tumours treated in childhood. Five year survival rates now exceed 75% and assessing the quality of survival (QoS) in multiple domains is essential to any comparison of the benefits and harms of treatment regimens.AimThe aim of this position statement is to rationalise assessments and facilitate collection of a common data set across Europe. Sufficient numbers of observations can then be made to enable reliable comparisons between outcomes following different tumour types and treatments.MethodsThis paper represents the consensus view of the QoS working group of the Brain Tumour group of the European Society of Paediatric Oncology regarding domains of QoS to prioritise for assessment in clinical trials. This consensus between clinicians and researchers across Europe has been arrived at by discussion and collaboration over the last eight years.ResultsAreas of assessment discussed include core medical domains (e.g. vision, hearing, mobility, endocrine), emotion, behaviour, adaptive behaviour and cognitive functioning.ConclusionsA ‘core plus’ approach is suggested in which core assessments (both direct and indirect tests) are recommended for all clinical trials. The core component is a relatively brief screening assessment that, in most countries, is a sub-component of routine clinical provision. The ‘plus’ components enable the addition of assessments which can be selected by individual countries and/or tumour-, age-, and location-specific groups. The implementation of a QoS protocol common to all European clinical studies of childhood brain tumours is also discusse

Acknowledging teacher professionalism in Ireland: the case for a chartered teacher initiative

This paper presents an argument for the development of an Irish Chartered Teacher initiative which would acknowledge and accredit the professionalism of experienced and accomplished teachers. It begins by examining the current position of teaching as a profession based on findings from Irish and international research studies. Issues surrounding the accreditation of accomplished teachers are considered through the examination of a range of Chartered Teacher initiatives. Finally, the potential opportunities and challenges of accrediting teacher professionalism in Ireland are discussed with reference to the continuum of teacher education and recent developments introduced by the Teaching Council of Ireland