32 research outputs found
Capacidade funcional para atividades da vida diĂĄria de idosos da EstratĂ©gia de SaĂșde da FamĂlia da zona rural
Indicadores sĂłcio-demogrĂĄficos e a epidemia de dengue em 2002 no Estado do Rio de Janeiro, Brasil
A distribuição dos eosinófilos nas diferentes fases de evolução do granuloma hepåtico em camundongos infectados pelo Schistosoma mansoni
Avaliação da assistĂȘncia farmacĂȘutica Ă gestante na rede bĂĄsica de saĂșde do MunicĂpio de Praia Grande, SĂŁo Paulo, Brasil
Strategies towards potent trypanocidal drugs: Application of Rh-catalyzed [2âŻ+âŻ2âŻ+âŻ2] cycloadditions, sulfonyl phthalide annulation and nitroalkene reactions for the synthesis of substituted quinones and their evaluation against Trypanosoma cruzi
Rhodium-catalyzed [2 + 2 + 2] cycloadditions, sulfonyl phthalide annulations and nitroalkene reactions have been employed for the synthesis of 56 quinone-based compounds. These were evaluated against Trypanosoma cruzi, the parasite that causes Chagas disease. The reactions described here are part of a program that aims to utilize modern, versatile and efficient synthetic methods for the one or two step preparation of trypanocidal compounds. We have identified 9 compounds with potent activity against the parasite; 3 of these were 30-fold more potent than benznidazole (Bz), a drug used for the treatment of Chagas disease. This article provides a comprehensive outline of reactions involving over 120 compounds aimed at the discovery of new quinone-based frameworks with activity against T. cruzi
PrevalĂȘncia de pectus carinatum e pectus excavatum em escolares de Manaus Prevalence of pectus carinatum and pectus excavatum in students in the city of Manaus, Brazil
OBJETIVO: Determinar a prevalĂȘncia das deformidades congĂȘnitas da parede torĂĄcica anterior em escolares de 11 a 14 anos. MĂTODOS: Participaram do estudo escolares da rede estadual de ensino da cidade de Manaus (AM). Para a composição de uma amostra estatisticamente significativa, com precisĂŁo de 1% e IC95%, foram incluĂdos 1.332 escolares. A deformidade pectus foi identificada atravĂ©s de exame fĂsico do tĂłrax, e os indivĂduos com esta deformidade responderam a um questionĂĄrio com questĂ”es sobre hereditariedade e sintomatologia decorrente da anomalia torĂĄcica. RESULTADOS: A idade mĂ©dia dos participantes foi de 11,7 anos. A prevalĂȘncia da deformidade pectus foi de 1,95% (pectus excavatum: 1,275%; pectus carinatum: 0,675%). Dos 26 escolares com deformidades pectus, 17 (65,4%) tinham pectus excavatum, e 18 (69,2%) eram do sexo masculino. Houve associação com a escoliose em 3 casos (11,5%). HistĂłria familiar de pectus foi relatada por 17 escolares (65,4%), e 17 (65,4%) relataram dor torĂĄcica, dispneia ou palpitaçÔes. CONCLUSĂES: A prevalĂȘncia das deformidades pectus encontrada neste estudo (1,95%) foi inferior Ă quela de trabalhos em outras regiĂ”es do paĂs (3,6-4,9%), porĂ©m, superior Ă quela relatada na literatura (mĂ©dia, 1%).<br>OBJECTIVE: To determine the prevalence of congenital anterior chest wall deformities in 11- to 14-year-old students. METHODS: Students participating in the study were recruited from public schools in the city of Manaus, Brazil. The statistically significant sample (precision, 1%; 95% CI) comprised 1,332 students. Pectus deformities were identified by physical examination of the chest, and the individuals with one of these deformities completed a questionnaire regarding heredity and symptoms resulting from the chest abnormality. RESULTS: The mean age of the participants was 11.7 years. The prevalence of pectus abnormalities was 1.95% (pectus excavatum: 1.275%; pectus carinatum: 0.675%). Of the 26 students with a pectus deformity, 17 (65.4%) had pectus excavatum, and 18 (69.2%) were male. Concomitant scoliosis was observed in 3 cases (11.5%). A family history of pectus was reported by 17 students (65.4%), and 17 (65.4%) reported chest pain, dyspnea or palpitations. CONCLUSIONS: In this study, the prevalence of pectus deformities (1.95%) was lower than that reported in other studies conducted in Brazil (3.6-4.9%) but was higher than that reported in the literature (mean, 1%)