A food-based approach could improve dietary adequacy for 12-23-month-old Eastern Ugandan children.

Little is known about dietary adequacy, for young Ugandan children, or context-specific food choices to improve it. This study estimated the percentage of breastfed 12-23-month-old rural Eastern Ugandan children (n = 114) at risk of inadequate intakes of 12 nutrients; and identified realistic food choices for improving it. In this cross-sectional survey, dietary (weighed food records), anthropometric and socioeconomic data were collected. The percentages of children at risk of inadequate nutrient intakes were estimated, assuming 541 g/day of breast milk was consumed. The median nutrient densities of their complementary feeding diets were also compared with desired levels. Linear programming analyses were used to identify 'problem nutrients' (where requirements will be difficult to meet given dietary practices) and model food choices to improve dietary adequacy. Overall, 21.2% of children were stunted and 3.8% were wasted. A high percentage (>45%) of children were at risk of inadequate intakes, for nine of the 12 nutrients assessed, and dietary nutrient densities were below desired levels for seven of the 12 nutrients. Iron, calcium, thiamine and niacin were 'problem nutrients'. Through careful selection of foods, modelling indicates that population level dietary adequacy can be achieved for eight of the 12 nutrients modelled. These choices include cows' milk, legumes, green leafy vegetables, sweet potatoes and fruits. Overall results suggest these high percentages of children at risk of inadequate nutrient intakes can be reduced through behaviour change interventions, although additional interventions may be required to ensure population-level dietary adequacy for iron, thiamine and niacin

The Early Light Curve of a Type Ia Supernova 2021hpr in NGC 3147: Progenitor Constraints with the Companion Interaction Model

The progenitor system of Type Ia supernovae (SNe Ia) is expected to be a close binary system of a carbon/oxygen white dwarf (WD) and a non-degenerate star or another WD. Here, we present results from a high-cadence monitoring observation of SN 2021hpr in a spiral galaxy, NGC 3147, and constraints on the progenitor system based on its early multi-color light curve data. First, we classify SN 2021hpr as a normal SN Ia from its long-term photometric and spectroscopic data. More interestingly, we found a significant "early excess" in the light curve over a simple power-law $\sim t^{2}$ evolution. The early light curve evolves from blue to red and blue during the first week. To explain this, we fitted the early part of $BVRI$-band light curves with a two-component model of the ejecta-companion interaction and a simple power-law model. The early excess and its color can be explained by shock cooling emission due to a companion star having a radius of $8.84\pm0.58$$R_{\odot}$. We also examined HST pre-explosion images with no detection of a progenitor candidate, consistent with the above result. However, we could not detect signs of a significant amount of the stripped mass from a non-degenerate companion star ($\lesssim0.003\,M_{\odot}$ for H$\alpha$ emission). The early excess light in the multi-band light curve supports a non-degenerate companion in the progenitor system of SN 2021hpr. At the same time, the non-detection of emission lines opens a door for other methods to explain this event.Comment: 26 pages, 13 figures + appendix, Accepted for publication in Ap

EHMT2 Inhibition Induces Cell Death in Human Non-Small Cell Lung Cancer by Altering the Cholesterol Biosynthesis Pathway

Non-small cell lung cancer (NSCLC) is a major subtype of lung cancer. Besides genetic and environmental factors, epigenetic alterations contribute to the tumorigenesis of NSCLC. Epigenetic changes are considered key drivers of cancer initiation and progression, and altered expression and activity of epigenetic modifiers reshape the epigenetic landscape in cancer cells. Euchromatic histone-lysine N-methyltransferase 2 (EHMT2) is a histone methyltransferase and catalyzes mono- and di-methylation at histone H3 lysine 9 (H3K9me1 and H3K9me2, respectively), leading to gene silencing. EHMT2 overexpression has been reported in various types of cancer, including ovarian cancer and neuroblastoma, in relation to cell proliferation and metastasis. However, its role in NSCLC is not fully understood. In this study, we showed that EHMT2 gene expression was higher in NSCLC than normal lung tissue based on publicly available data. Inhibition of EHMT2 by BIX01294 (BIX) reduced cell viability of NSCLC cell lines via induction of autophagy. Through RNA sequencing analysis, we found that EHMT2 inhibition significantly affected the cholesterol biosynthesis pathway. BIX treatment directly induced the expression of SREBF2, which is a master regulator of cholesterol biosynthesis, by lowering H3K9me1 and H3K9me2 at the promoter. Treatment of a cholesterol biosynthesis inhibitor, 25-hydroxycholesterol (25-HC), partially recovered BIX-induced cell death by attenuating autophagy. Our data demonstrated that EHMT2 inhibition effectively induced cell death in NSCLC cells through altering cholesterol metabolism-dependent autophagy

Catalytic C–H Allylation and Benzylation of Pyrazoles

We describe a general approach for the synthesis of allylated and benzylated pyrazoles. An electron-withdrawing substituent, such as nitro, chloro, and ester groups, at C4 renders the Lewis basic nitrogen atom to be less basic and the C–H bond more acidic than the ones of the parent ring, enabling Pd-catalyzed C–H allylation and benzylation reactions of pyrazoles. The new method expanding the scope of the C–H functionalization of pyrazoles beyond arylation reactions provides a rapid access to complex pyrazole compounds

Effects of shear-thickening polymer on force attenuation capacities in hip protectors

Many elderly people use hip protectors to prevent hip fractures from sideways falls. These hip protectors absorb or shunt away the energy applied to the greater trochanter. Herein, shear-thickening polymer (STP)-based hip protectors composed of STP and polyurethane foam are studied. The purpose of this study was to identify the main factor that reduces the impact force directly applied to the femoral neck region and to determine the optimal thickness of STP in hip protectors. Seven hip protectors of different thicknesses were prepared, and two sets of free-fall mechanical tests with a low impact energy of 25.1 J and moderate impact energy of 44.1 J were conducted for each hip protector. When the thickness of STP exceeded 8 mm, the resultant peak force tended to plateau under both impact conditions, and the force attenuation capacity decreased even under low impact energy conditions. Thus, a hip protector with a 6 mm or 8 mm STP and 5 mm foam was recommended. The STP was the key factor affecting force attenuation capacity, not the polyurethane foam. However, the foam also played an important role in helping the STP function and improving compliance for users.N

Unraveling the Simultaneous Enhancement of Selectivity and Durability on Single-Crystalline Gold Particles for Electrochemical CO2 Reduction

Electrochemical carbon dioxide reduction is a mild and eco-friendly approach for CO2 mitigation and producing value-added products. For selective electrochemical CO2 reduction, single-crystalline Au particles (octahedron, truncated-octahedron, and sphere) are synthesized by consecutive growth and chemical etching using a polydiallyldimethylammonium chloride (polyDDA) surfactant, and are surface-functionalized. Monodisperse, single-crystalline Au nanoparticles provide an ideal platform for evaluating the Au surface as a CO(2)reduction catalyst. The polyDDA-Au cathode affords high catalytic activity for CO production, with >90% Faradaic efficiency over a wide potential range between -0.4 and -1.0 V versus RHE, along with high durability owing to the consecutive interaction between dimethylammonium and chloride on the Au surface. The influence of polyDDA on the Au particles, and the origins of the enhanced selectivity and stability are fully investigated using theoretical studies. Chemically adsorbed polyDDA is consecutively affected the initial adsorption of CO2 and the stability of the *CO2, *COOH, and *CO intermediates during continuous CO2 reduction reaction. The polyDDA functionalization is extended to improving the CO Faradaic efficiency of other metal catalysts such as Ag and Zn, indicating its broad applicability for CO2 reduction

Development and implementation of patient-level prediction models of end-stage renal disease for type 2 diabetes patients using fast healthcare interoperability resources

This study aimed to develop a model to predict the 5-year risk of developing end-stage renal disease (ESRD) in patients with type 2 diabetes mellitus (T2DM) using machine learning (ML). It also aimed to implement the developed algorithms into electronic medical records (EMR) system using Health Level Seven (HL7) Fast Healthcare Interoperability Resources (FHIR). The final dataset used for modeling included 19,159 patients. The medical data were engineered to generate various types of features that were input into the various ML classifiers. The classifier with the best performance was XGBoost, with an area under the receiver operator characteristics curve (AUROC) of 0.95 and area under the precision recall curve (AUPRC) of 0.79 using three-fold cross-validation, compared to other models such as logistic regression, random forest, and support vector machine (AUROC range, 0.929-0.943; AUPRC 0.765-0.792). Serum creatinine, serum albumin, the urine albumin-to-creatinine ratio, Charlson comorbidity index, estimated GFR, and medication days of insulin were features that were ranked high for the ESRD risk prediction. The algorithm was implemented in the EMR system using HL7 FHIR through an ML-dedicated server that preprocessed unstructured data and trained updated data.N

Evaluation of the conventional and modified aerosol boxes during tracheal intubation in normal and difficult airways: a randomized, crossover, manikin simulation study

© 2022, The Author(s), under exclusive licence to Springer Nature B.V.The aim of this study was to evaluate conventional and modified aerosol boxes in terms of intubation time, first-pass intubation success, and mouth-to-mouth distance between the laryngoscopist and patient during tracheal intubation in simulated patients with normal and difficult airways. Sixteen anesthesiologists performed tracheal intubations with direct laryngoscope or three different videolaryngoscopes (McGRATH MAC videolaryngoscope, C-MAC videolaryngoscope, and Pentax-AWS) without an aerosol box or with a conventional or a modified aerosol boxes in simulated manikins with normal and difficult airways. Intubation time, first-pass intubation success, and mouth-to-mouth distance during tracheal intubation were recorded. Compared to no aerosol box, the use of a conventional aerosol box significantly increased intubation time in both normal and difficult airways (Bonferroni-corrected P-value (Pcorrected) = 0.005 and Pcorrected = 0.003, respectively). Intubation time was significantly shorter with the modified aerosol box than with the conventional one for both normal and difficult airways (Pcorrected = 0.003 and Pcorrected = 0.011, respectively). However, no significant differences were found in intubation time between no aerosol box and the modified aerosol box for normal and difficult airways (Pcorrected = 0.336 and Pcorrected = 0.112, respectively). The use of conventional or modified aerosol boxes significantly extended the mouth-to-mouth distances compared to not using an aerosol box during tracheal intubation with each laryngoscope (all Pcorrected < 0.05), and the distances were not different between the conventional and modified boxes in normal and difficult airways. The use of modified aerosol box did not increase intubation time and could help maintain a distance from the simulated patients with normal and difficult airways.N