Diagnostic test accuracy of newly described CDR.

<p>CI = confidence intervals; IQR = interquartile range.</p

Individual diagnostic test accuracy of ‘Alexander’ rule.

<p>The light lines and circles represent individual studies, with the darker dashed lines showing the study from which the rule was derived.</p

Validations of rules.

<p>Validations of rules.</p

Clinical decision rules examined.

<p>AML = acute myeloid leukaemia; ANC = Absolute neutrophil count; BMT = bone marrow transplant; CXR = chest radiograph; CRP = C-reactive protein; PINDA = Programa Infantil Nacional de Drogas Antineoplásticas; SPOG = Swiss Pediatric Oncology Group; URTI = upper respiratory tract infection.</p

Flowchart of studies through the review.

<p>Flowchart of studies through the review.</p

Individual and pooled diagnostic test accuracy of ‘PINDA’ rule.

<p>The light lines and circles represent individual studies, with the darker dashed lines showing the study from which the rule was derived.</p

Individual and pooled diagnostic test accuracy of ‘Klaassen’ rule.

<p>The ROC space plots show each study estimates of sensitivity and specificity as a marker at the point estimate, with 95% confidence intervals demonstrated by lines. In reading such graphs, tests with a better discriminatory ability fall in the top left corner of the plot, and non-discriminatory tests fall on a 45° line between the bottom left and top right. The light lines and circles represent individual studies, with the darker dashed lines showing the study from which the rule was derived. The dark circle is the pooled estimate of sensitivity and specificity, and the dashed ellipse represents the bivariate 95% confidence intervals of this result.</p

Forest plots of the odds ratios and confidence intervals of breast cancer associations in the homozygous model for (A) post-menopausal and (B) pre-menopausal women.

<p>Forest plots of the odds ratios and confidence intervals of breast cancer associations in the homozygous model for (A) post-menopausal and (B) pre-menopausal women.</p

Summary of Literature Search.

<p>Summary of Literature Search.</p

Proportion of adverse outcomes (attributable risk) due to poor socioeconomic prognosticators in studies of the effect of dichotomous measures of income and insurance in acute lymphoblastic leukemia and Hodgkin lymphoma, as well as of selected biologic prognosticators by way of comparison.

<p>ALL – acute lymphoblastic leukemia; AML – acute myeloid leukemia; AR – attributable risk; HIC – high-income country; HL – Hodgkin lymphoma; LMIC – low- to middle-income country; MRD – minimal residual disease; p_e – proportion of population exposed to the adverse prognosticator; RR – risk ratio; SES – socioeconomic status.</p