Additional file 1 of Development and validation of an MRI-based radiomic model for predicting overall survival in nasopharyngeal carcinoma patients with local residual tumors after intensity-modulated radiotherapy

Additional file 1. Radiotherapy protoco

The main characteristics of Chinese TM patients along with the main results of the study.

<p><b>DFO</b>,deferoxamine; <b>DFP</b>, deferiprone; <b>DFX</b>, deferasirox; <b>SD</b>, standard deviation; <b>SF</b>, serum ferritin; <b>LVEF</b>, left ventricular ejection fraction.</p><p><b>^a:</b> patients received both DFO and DFP as prior chelation therapies, but these may not have been in combination.</p><p><b>^b:</b> patients received both DFO and deferasirox as prior chelation therapies, but these may not have been in combination.</p

Correlation between cardiac T2* and serum ferritin(SF) values in Chinese TM patients.

<p>Cardiac T2* was negatively associated with SF (r = −0.319, p = 0.000). The dotted line represents reference range for cardiac T2* of 20 ms, and the solid line represents SF of 2500 ng/ml.</p

Correlation between cardiac T2* and age in Chinese TM patients.

<p>The dotted line represents cardiac T2* of 20 ms. The solid line represents age of 6 years old. Cardiac T2* was negatively associated with age (r = −0.328, p = 0.000) in these patients.</p

Correlation between cardiac T2* and left ventricular ejection fraction (LVEF) in Chinese TM patients.

<p>No correlation was found between cardiac T2* and LVEF (r = −0.147, p = 0.052). The solid line presents reference range (56%) for LVEF. The dotted line represents reference range for cardiac T2* of 20 ms.</p

Correlation between cardiac T2* and total units of blood transfused in Chinese TM patients.

<p>Cardiac T2* was negatively associated with units of transfused blood(r = −0.360, p = 0.000).</p

Regions showing fALFF differences between groups.

<p>x, y, z, coordinates of primary peak locations in the MNI space; <i>t</i> statistical value of peak voxel showing fALFF differences between the patients with SD and the controls. SD: somatization disorder.</p

The DMN mask produced in our previous studies.

<p>DMN = default mode network.</p

fALFF differences between the patients with SD and the controls.

<p>Red and blue denote higher and lower fALFF respectively and the color bars represent the <i>t</i> value of the group analysis. fALFF = fractional amplitudes of low-frequency fluctuations; SD = somatization disorder.</p

Voxel-wise correlation between the MPFC and the somatization subscale scores of SCL-90 in the patients.

<p>Sagittal view of the voxel-wise correlation analysis between z values of the voxels within the the bilateral superior MPFC (Montreal Neurological Institute coordinates: x = −4, y = 42, z = 52) and the somatization subscale scores of SCL-90 in the patient group at 0.05 significance level (combined height threshold <i>p</i><0.01 and a minimum cluster size = 52). MPFC = medial prefrontal cortex; somatization subscale of SCL-90 = somatization subscale of the Symptom Check List.</p