Обзор вакцинации против папилломавирусной инфекции в мире

The article presents an overview of the current status of the vaccination against Human Papillomavirus (HPV) in the world. It describes different approaches to expanding the coverage with HPV vaccination at different national levels by inclusion of the vaccine in National Immunization Programmes. Moreover, the principal ways of project financing in different regions of the world are referred to. The results of the implemented vaccination against HPV in the pioneer countries provide the conclusions on the current situation of HPV vaccination in the world and strategies demonstrating its effectiveness.В статье представлены сведения о текущем состоянии проблемы профилактики папилломавирусной инфекции среди населения разных стран мира. Описаны пути включения прививки против вируса папилломы человека в государственные национальные программы иммунизации. Кроме того, отражены возможные способы финансирования внедряемого проекта для каждого региона мира. Результаты внедренной иммунизации против папилломавирусной инфекции в странах-пионерах позволили сделать выводы не только о текущем состоянии вакцинации населения этих государств, но также о результатах ее эффективности.Конфликт интересовЛ.С. Намазова-Баранова — получение исследовательских грантов от фармацевтических компаний Пьер Фабр, Genzyme Europe B. V., ООО «Астра зенека Фармасьютикалз», Gilead/PRA «Фармасьютикал Рисерч Ассошиэйтс СиАйЭс», «Bionorica», Teva Branded Pharmaceutical products R&D, Inc/ООО «ППД Девелопмент (Смоленск)», «Сталлержен С. А.»/«Квинтайлс ГезмбХ» (Австрия). М. В. Федосеенко — получение гонораров от компании Sanofi, Pfizer за чтение лекций

ВАКЦИНАЦИЯ ПОДРОСТКОВ В ЕВРОПЕЙСКОМ РЕГИОНЕ. СОВРЕМЕННОЕ СОСТОЯНИЕ ПРОБЛЕМЫ

This article describes the peculiarities of the National immunization programs for adolescents in the WHO Euro region. A comparative analysis of the groups was conducted based on economic development. The best and the worst performing states were identified in every group. It was demonstrated that economic development is not the leading factor that determines a country’s vaccination policy. В статье описаны особенности национальных программ вакцинации подростков стран Европейского региона Всемирной организации здравоохранения,  и в зависимости от уровня развития экономики выполнен сравнительный анализ по группам лидирующих и отстающих стран. Показано, что экономический фактор не является ведущим в определении политики вакцинации в стране и расширения национального календаря прививок

Ротавирусная инфекция у детей — нерешенная проблема. Обзор рекомендаций по вакцинопрофилактике

These clinical guidelines were developed by the professional association of pediatric specialists «Union of Pediatricians of Russia» and approved by the Association’s Executive Committee at the Congress of Pediatricians of Russia «Actual Problems of Pediatrics». Clinical guidelines are devoted to the problem of rotavirus infection, the relevance of which is determined by the high prevalence level and significant contribution of infectious diarrhea to the mortality pattern of children in the first 5 years of life. We present epidemiological data and detailed information on the infectious agent and pathogenesis of rotavirus infection progression. A detailed picture of clinical manifestations as well as extraintestinal complications is presented. The approach to specific prophylaxis has been reasoned. Practical recommendations for immunization as well as various regimens for administering the vaccine, depending on the age and condition of the patient, are given.Данные клинические рекомендации разработаны профессиональной ассоциацией детских специалистов «Союз педиатров России» и утверждены Исполкомом ассоциации на Съезде педиатров России «Актуальные проблемы педиатрии». Клинические рекомендации посвящены проблеме ротавирусной инфекции, актуальность которой определяется высоким уровнем распространенности и значительным вкладом инфекционной диареи в структуру смертности детей первых 5 лет жизни. Приводятся эпидемиологические данные, подробно описаны особенности возбудителя, патогенез развития ротавирусной инфекции. Представлена развернутая картина клинических проявлений, а также внекишечных осложнений. Обоснована тактика специфической профилактики. Даны практические рекомендации по проведению иммунизации, а также различные схемы введения вакцины в зависимости от возраста и состояния пациента

Theoretical Background and Real Results: A Data Review on Vaccine Prevention of Pneumococcal Infection in the World

The article presents the review aimed at summarizing the opinions on the epidemiology of pneumococcal infection and the most effective measures for its prevention. The review combines the results of the trials conducted by Russian and international groups who analysed vaccine prophylaxis of pneumococcal infection. In the previous review on the most important indicators of the effectiveness of vaccination against pneumococcal infection, the main approaches to the assessment of the effectiveness of vaccination against pneumococcal infection were identified, and the academic data on the global experience of pneumococcal conjugate vaccination was systematized. This review results in cumulation of evidence for the efficacy and impact of pneumococcal conjugate vaccines on the key «end points» of the epidemiological process of pneumococcal infection

Overview of the Global Vaccination against Human Papillomavirus

The article presents an overview of the current status of the vaccination against Human Papillomavirus (HPV) in the world. It describes different approaches to expanding the coverage with HPV vaccination at different national levels by inclusion of the vaccine in National Immunization Programmes. Moreover, the principal ways of project financing in different regions of the world are referred to. The results of the implemented vaccination against HPV in the pioneer countries provide the conclusions on the current situation of HPV vaccination in the world and strategies demonstrating its effectiveness

VACCINATION FOR ADOLESCENTS IN THE EUROPEAN REGION: CURRENT STATE OF THE PROBLEM

This article describes the peculiarities of the National immunization programs for adolescents in the WHO Euro region. A comparative analysis of the groups was conducted based on economic development. The best and the worst performing states were identified in every group. It was demonstrated that economic development is not the leading factor that determines a country’s vaccination policy

VACCINATION AGAINST ROTAVIRUS INFECTION: 10-YEAR GLOBAL EXPERIENCE OF SUCCESSFUL USE

The article reviews the results of scientific researches published over the past few years that confirm the significant socioeconomic burden of rotavirus infection and its significant contribution to the morbidity and mortality of the world’s children’s population. The authors presented evidence of the effectiveness of immunization in the routine schedule of preventive vaccinations of infants in both developed and developing countries. A significant reduction in mortality and admissions due to severe forms of rotavirus gastroenteritis during the first years of introduction of rotavirus vaccination was shown, which marked a positive trend in the development of health care

Rotavirus Infection in Children is an Unsolved Problem. Review of Guidelines for Vaccinal Prevention

These clinical guidelines were developed by the professional association of pediatric specialists «Union of Pediatricians of Russia» and approved by the Association’s Executive Committee at the Congress of Pediatricians of Russia «Actual Problems of Pediatrics». Clinical guidelines are devoted to the problem of rotavirus infection, the relevance of which is determined by the high prevalence level and significant contribution of infectious diarrhea to the mortality pattern of children in the first 5 years of life. We present epidemiological data and detailed information on the infectious agent and pathogenesis of rotavirus infection progression. A detailed picture of clinical manifestations as well as extraintestinal complications is presented. The approach to specific prophylaxis has been reasoned. Practical recommendations for immunization as well as various regimens for administering the vaccine, depending on the age and condition of the patient, are given

Клинические рекомендации по ведению детей с дефицитом лизосомной кислой липазы

Lysosomal acid lipase deficiency is s a rare hereditary enzymopathy. The article presents epidemiological data and features of etiopathogenesis of two phenotypic forms of lysosomal acid lipase deficiency — Wolman disease and cholesterol ester storage disease. Special attention has been given to the key issues of differential diagnostic search, clinical guidelines based on the principles of evidence-based medicine have been given.Дефицит лизосомной кислой липазы — редкая наследственная ферментопатия. В статье представлены эпидемиологические данные и особенности этиопатогенеза двух фенотипических форм дефицита лизосомной кислой липазы — болезни Вольмана и болезни накопления эфиров холестерина. Подробно описаны клинические характеристики быстропрогрессирующей формы и медленно развивающейся болезни накопления эфиров холестерина. Особое внимание уделено ключевым вопросам дифференциально-диагностического поиска, приведены рекомендации по лечению, основанные на принципах доказательной медицины