Паковирин – альтернатива в комплексном лечении острого вирусного гепатита С

USMF Nicolae TestemiţanuSummary. There were examined 64 patients with viral acute hepatitis C hospitalized in Toma Ciorba IDCH. These patients were divided into two groups: the first one (based) was treated with Pacovirine and the second (control), with Placebo. For treatment efficiency assessment were estimated the following examination results: clinical, biochemical and immunological. The obtained results analysis show that this treatment method is efficient. Adverse reactions during and after treatment weren’t observed.Резюме. Были исследованы 64 больных с острым вирусным гепатитом С (ВГС острый), интернированные в РИГБ «Тома Чорбэ». Эти пациенты были разделены на 2 группы: I группа (основная), получавшая паковирин, и II (контроль), обработанные плацебо. Эффективность была оценена результатами следующих исследований: клинические, биохимические и иммунологические. Анализ результатов показал, что этот метод лечения является эффективным. Побочных эффектов во время и после лечения не наблюдалось

Evolution of erysipelas depending on the localization

Catedra Boli Infecţioase, tropicale şi parazitologie medicală USMF „Nicolae Testemiţanu”Streptococcal infections are wide spread in human population. Although usually it has no severe complications, erysipel, has a sufficient high incidence and this is why this disease represents the object of various scientific researches. Study of evolutional particularities of this streptococcal disease is justified by frequent relapses which affect the patient, and also by the socio-economical impact of this illness. The study includes 100 patients with erysipel. This study aims to analyse the interdependence between clinical type of the disease, localization of erysipel and its gravity. Infecţiile streptococice sunt foarte răspândite în rândurile populaţiei umane. Deşi în mod obişnuit nu lasă complicaţii grave, erizipelul are o incidenţă înaltă pentru a prezenta obiectul multor cercetări ştiinţifice. Studiul particularităţilor evolutive ale acestei infecţii streptococice este justificat în legătură cu recăderile frecvente ce se înregistrează la pacienţi, precum şi de impactul socio-economic al maladiei. În studiu au fost incluşi 100 bolnavi de erizipel. Scopul lucrării constă în studierea corelaţiilor dintre localizarea procesului, formele clinice şi gravitatea acestuia

Менеджмент острого вирусного гепатита С

USMF N. Testemiţanu, IMSP SCBI Toma CiorbăSummary. The importance and necessity of the present study was imposed by the fact that a standard antiviral treatment was not elaborated in case of acute viral hepatitis C (AVHC). Taking into account the large percentage of chronicity of hepatitis with virus C, the treatment itself should be an antiviral one. To establish the effi ciency of combined antiviral treatment with pegasys and copegus, 40 patients with AVHC participated in the study, 12 of which were females (30%) and 28 males (70%) of average age 43,54 ±1,68 years old. To confi rm the diagnosis anamnesis, clinical, epidemiological and laboratory data have been analized. The haemoleucogram, biochemical tests of the liver (bilirubin, ALAT, thymol test, prothrombin), the markers of the viral C hepatitis (anti-VHC IgM, anti-VHC tot9) were investigated by excluding other viral hepatites (by determining the viral B and D hepatites markers), the abdominal ecography and the ARN-VHC by PCR. A combined antiviral treatment was initiated with pegasys+copegus. The clinical symptomatology of the patients in the study was demonstrated by symptoms of dispeptic asthenic and arthralgic symptoms. The contamination occured mainly paranterally. The treatment with pegasys + copegus was effi cient (SVR – 100%) and can be recommended for acute forms of hepatitis C.Резюме. Актуальность проводимых исследований состоит в том, что до сих пор не разработан стандарт противовирусного лечения острого вирусного гепатита С (ОВТС). Под наблюдением находились 40 больных с ОВГС – 12 женщин и 28 мужчин, у которых диагноз установлен на основании биохимических, серологических и молекулярно-биологических методов исследования. Было назначено комбинированное лечение пегасисом и копегусом. Пегасис – 180 мкг в неделю в.м. а копегус – в дозе 1000 – 1200 мг в день, в зависимости от веса. Длительность лечения – от 12, 24 и 48 недель. Лечение пегасисом и копегусом было эффективным и привело к 100% выздоровлению и может быть рекомендовано для лечения острых форм гепатита С

Цитомикс в лечении хронического вирусного гепатита С

USMF N. Testemiţanu, IMSP Spitalul Clinic de Boli Infecţioase Toma CiorbăSummary. The treatment with cytomix of 30 patients with chronic viral hepatitis C, for 4 months contributed to the improvement till the disappearance of clinical symptoms; the improvement of cytolysis syndrome indices, which indicates in favour of hepatoprotective features of the drug; a moderate decrease of anti-HVC IgM titres with a bias in 2 was found; an improvement of the immune status was seen until a normal one in 66,6% of the patients enroled in the study, which confi rms immunomodulatory properties of the drug.Резюме. Под наблюдениием находились 30 больных хроническим вирусным гепатитом С. Им было назначено лечение цитомиксом 2 раза в день, утром и вечером, в течение 4 месяцев. Лечение привело к улучшению общего состояния и снижению, а в некоторых случаях и к нормализации биохимических покозателей функции печени, что демонстрирует гепатопротективное свойство цитомикса. Снижение титров аnti-VHC IgM у некоторых больных, а также нормализация иммунологических показателей у 66,6% больных свидетельствуют об иммуномодулирующем свойстве препарата

Evolutive, clinical features and treatment in cytomegalic infection

Catedra Boli infecţioase FECMF, USMF ”Nicolae Testemiţanu” IMSP SCBI „Toma Ciorba”The study includes investigations of 25 cases of cytomegalovirus infection, hospitalized CHID "T.Ciorba " in 2007-2011. The diagnosis was based on clinical, anamnestic data and tests for detecting anti-CMV IgM and IgG. Clinical symptoms were mononucleosis syndrome and liver damage. The disease evolution was favorable, even without antiviral treatment. Studiul se referă la 25 cazuri de infecţie cu Citomegalovirus la adulţi, spitalizaţi în IMSP SCBI “T. Ciorba” în perioada 2007-2011. Diagnosticul a fost confirmat prin datele clinico-anamnestice şi testele de laborator cu depistarea anticorpilor specifici anti-CMV IgM şi IgG. Tabloul clinic la majoritatea pacienţilor a constat din prezenţa sindromului mononucleozic şi simptome de afectare hepatică. Evoluţia maladiei a fost favorabilă chiar fără administrarea de remedii antiviral

Considerations on a case of viral hepatitis E

Catedra Boli infecţioase FECMF, USMF "Nicolae Testemiţanu"Viral Hepatitis E is an infectious disease which is prevalently spread in Asia (India, Pakistan) and in some regions of Africa, Central and South America but there were described some imported cases in Spain and Italy. Hepatitis E was previously thought to be a disease of developing countries causing significant morbidity and mortality in young adults, particularly among pregnant women and patients with pre-existing chronic liver disease. We present a case of a 54 years old woman patient, which was admitted to the Clinical Hospital of Infectious Disease „T. Ciorbă”. The case was confirmed by epidemiological history, clinical, laboratory examination and instrumental investigations. Hepatita virală E este o maladie infecţioasă, preponderent răspândită în Asia (India, Pakistan) şi în unele regiuni din Africa, America Centrală şi de Sud şi au fost descrise cazuri de import în Spania, Italia.Hepatita E se credea a fi o boală în ţările în curs de dezvoltare care cauzează morbiditate şi mortalitate la adulţii tineri, în special în rândul femeilor însărcinate şi pacienţii cu boli hepatice cronice pre-existente. Vom prezenta un caz clinic de hepatită virală E acută care a fost internată la Spitalul Clinic de Boli Infecţioase „T. Ciorbă”. Cazul a fost confirmat prin date clinice, epidemiologice, de laborator şi investigaţii instrumentale

Characteristics of erysipel in relation to the localization of the process and clinical forms

Catedra Boli infecţioase, tropicale şi parazitologie medicalăStreptococcal infections are widely spread in human population. Although usually it has no severe complications, erysipel, has a sufficiently high incidence and this is why this disease represents the object of various scientific researches. Study of evolutional pecularities of this streptococcal disease is justified by frequent relapses which affect the patient, and also by the socio-economical impact of this illness. The study includes 30 patients with erysipel. This study aims to analyse the interdependence between the clinical type of the disease, localization of erysipel and its severity. Infecţiile streptococice sunt foarte răspândite în rândurile populaţiei umane. Deşi în mod obişnuit nu lasă complicaţii grave, erizipelul, are o incidenţă înaltă pentru a prezenta obiectul multor cercetări ştiinţifice. Studiul particularităţilor evolutive ale acestei infecţii streptococice este justificat de recăderile frecvente ce se înregistrează la pacienţi, precum şi de impactul socio-economic al maladiei. În studiu au fost incluşi 30 bolnavi de erizipel. Scopul lucrării constă în studierea corelaţiilor dintre formele clinice, localizarea procesului şi gravitatea acestuia

Hepatita virală G – cazuri clinice

Background. Viral hepatitis G (HVG) remains an important issue for practical medicine. The hepatitis G virus is part of the Flaviviridae family, with transmission through blood transfusions and other parenteral mechanisms, causing persistent chronic infections. In the absence of routine diagnostic testing, HVG often remains unconfirmed. Objective of the study. Presentation of two clinical cases in adults with chronic viral hepatitis G. Material and Methods. There are two clinical cases of HVG in adults, the disease being detected by molecular-biological laboratory investigations. The first case was confirmed in 2018, and the second in 2021 in the chronic phase of the disease. The specific investigations are performed due to the persistence of asthenovegetative, dyspeptic and cytolytic clinical syndromes, in the absence of other causes. At the objective clinical examination he presents the hepatosplenomegaly and at the biological examination - periodic increase the activity of aminotransferases. Markers of viral hepatitis B, C, D, CMV, EBV and autoimmune were investigated: ANA, AMA, anti-LKM-1, which were negative. Results. Standard treatment for chronic viral hepatitis has been effective with clinical and biological improvement. Conclusion. HVG in adults is manifested by dyspeptic syndrome, asthenovegetative syndrome, and hepato-splenomegaly. Standard treatment for chronic viral hepatitis has been effective.Introducere. Hepatita virală G (HVG) rămâne o problemă importantă pentru medicina practică. Virusul hepatitei G face parte din familia Flaviviridae, cu transmitere prin hemotransfuzii și alte mecanisme parenterale, determinând infecții cronice persistente. În absența efectuării de rutină a testelor specifice de diagnostic, HVG deseori rămâne neconfirmată. Scopul lucrării. Prezentarea a două cazuri clinice la adulți cu hepatită virală G cronică. Materiale și metode. Se prezintă 2 cazuri clinice de HVG la adulți, boala fiind depistată prin investigații molecular-biologice de laborator. Primul caz a fost confirmat în anul 2018, iar al doilea în 2021 în faza cronică a bolii, investigațiile specifice efectuându-se din cauza persistenței sindroamelor clinice astenovegetativ, dispeptic și citolitic, în absența altor cauze. La examenul clinic obiectiv prezentă hepatosplenomegalie, iar la examenul biologic creștere periodică a activității aminotransferazelor. Au fost investigați markerii hepatitelor virale B, C, D, CMV, EBV și autoimuni: ANA, AMA, anti-LKM-1, care au fost negativi. Rezultate. Tratamentul standard pentru hepatitele virale cronice a fost eficient cu ameliorarea clinică și biologică. Concluzii. HVG la adult s-a manifestat prin sindromul dispeptic, astenovegetativ și hepato-splenomegalie. Tratamentul standard pentru hepatitele virale cronice a fost eficient

VIRAL HEPATITIS G – CLINICAL CASES

Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, Chişinău, Republica MoldovaIntroducere. Hepatita virală G (HVG) rămâne o problemă importantă pentru medicina practică. Virusul hepatitei G face parte din familia Flaviviridae, cu transmitere prin hemotransfuzii și alte mecanisme parenterale, determinând infecții cronice persistente. În absența efectuării de rutină a testelor specifice de diagnostic, HVG deseori rămâne neconfirmată. Scopul lucrării. Prezentarea a două cazuri clinice la adulți cu hepatită virală G cronică. Materiale și metode. Se prezintă 2 cazuri clinice de HVG la adulți, boala fiind depistată prin investigații molecular-biologice de laborator. Primul caz a fost confirmat în anul 2018, iar al doilea în 2021 în faza cronică a bolii, investigațiile specifice efectuându-se din cauza persistenței sindroamelor clinice astenovegetativ, dispeptic și citolitic, în absența altor cauze. La examenul clinic obiectiv prezentă hepatosplenomegalie, iar la examenul biologic creștere periodică a activității aminotransferazelor. Au fost investigați markerii hepatitelor virale B, C, D, CMV, EBV și autoimuni: ANA, AMA, anti-LKM-1, care au fost negativi. Rezultate. Tratamentul standard pentru hepatitele virale cronice a fost eficient cu ameliorarea clinică și biologică. Concluzii. HVG la adult s-a manifestat prin sindromul dispeptic, astenovegetativ și hepato-splenomegalie. Tratamentul standard pentru hepatitele virale cronice a fost eficient.Background. Viral hepatitis G (HVG) remains an important issue for practical medicine. The hepatitis G virus is part of the Flaviviridae family, with transmission through blood transfusions and other parenteral mechanisms, causing persistent chronic infections. In the absence of routine diagnostic testing, HVG often remains unconfirmed. Objective of the study. Presentation of two clinical cases in adults with chronic viral hepatitis G. Material and Methods. There are two clinical cases of HVG in adults, the disease being detected by molecular-biological laboratory investigations. The first case was confirmed in 2018, and the second in 2021 in the chronic phase of the disease. The specific investigations are performed due to the persistence of asthenovegetative, dyspeptic and cytolytic clinical syndromes, in the absence of other causes. At the objective clinical examination he presents the hepatosplenomegaly and at the biological examination - periodic increase the activity of aminotransferases. Markers of viral hepatitis B, C, D, CMV, EBV and autoimmune were investigated: ANA, AMA, anti-LKM-1, which were negative. Results. Standard treatment for chronic viral hepatitis has been effective with clinical and biological improvement. Conclusion. HVG in adults is manifested by dyspeptic syndrome, asthenovegetative syndrome, and hepato-splenomegaly. Standard treatment for chronic viral hepatitis has been effective

Различия в клиническом течении рожи у молодых по сравнению с течением у людей среднего возраста и пожилых

Universitatea de Stat de Medicină şi Farmacie N. Testemiţanu, IMSP Spitalul Clinic de Boli Infecţioase Toma CiorbăРезюме. Было установлено, что в молодом возрасте рожа протекала легче. У людей старше 44 лет ожирение чаще всего явилось фоновым заболеванием, определившем появление рожи. Частота повреждения лица у молодых людей оказалось значительно больше, чем среди больных среднего возраста и пожилых, у которых преобладала рожа нижних конечностей. Осложнения рожи у больных молодого возраста происходили реже, особенно гнойные. Рожа протекала дольше: если были поражены нижние конечности, при наличии сопутствующих заболеваний (ожирение, сахарный диабет, тромбофлебит нижних конечностей, слоновость, стрептодермия и микозы подошв), при возрасте пациентов старше 60 лет.Summary. Study on clinical features depending on the patients’ age with erysipelas was performed on 79 persons. It was found that erysipelas in younger age people flowed more easily. In people over 44 years obesity was disease risk, which often favored the appearance of erysipelas. The frequency of damage face young people proved to be significantly increased, than in middle-aged and elderly, where erysipelas prevails location on the lower limbs. Complications in young erysipelas occurred less frequently, especially suppurative. Erysipelas went longer if: the localization of the inflammatory process is on the lower limbs, favoring the presence of concomitant diseases (obesity, diabetes, venous thrombophlebitis leg, elephantiasis, and plantar mycosis or streptodermia), patients’ age 60 years and more