A lightweight verifiable secret sharing scheme in IoTs

Verifiable secret sharing (VSS) is a fundamental tool of cryptography and distributed computing in Internet of things (IoTs). Since network bandwidth is a scarce resource, minimizing the number of verification data will improve the performance of VSS. Existing VSS schemes, however, face limitations in meeting the number of verification data and energy consumptions for low-end devices, which make their adoption challenging in resource-limited IoTs. To address above limitations, we propose a VSS scheme according to Nyberg’s oneway accumulator for one-way hash functions (NAHFs). The proposed scheme has two distinguished features: first, the security of the scheme is based on NAHFs whose computational requirements are the basic criteria for known IoT devices and, second, upon receiving only one verification data, participants can verify the correctness of both their shares and the secret without any communication. Experimental results demonstrate that, compared to the Feldman scheme and Rajabi-Eslami scheme, the energy consumption of a participant in the proposed scheme is respectively reduced by at least 24% and 83% for a secret

Verifiably Distributed Multi-User Secret Sharing schemes

Distributed secret sharing techniques, where a specific secret is encoded into its shares which are conveyed to the IoT device or its user via storage nodes, are considered. A verifiably distributed secret sharing (VDSS) provides a way for a legitimate user to verify the secret he reconstructs through the downloaded shares while the secrecy condition is satisfied in a weak or a perfect sense. This article examines the impact of minimizing verification information in a VDSS on the communication complexity and storage overhead, and achieves the verifiability in resource-limited IoTs by aggregating the verification information of different devices/users. Then, two secure VDSS are proposed. The first VDSS attains the lower bound on the communication complexity while providing the fault tolerance. The second VDSS simultaneously achieves the lower bounds of both communication complexity and storage overhead while providing the balanced storage load, thus showing the scheme that is optimal in terms of both parameters

Fortified Fermented Rice-Acid Can Regulate the Gut Microbiota in Mice and Improve the Antioxidant Capacity

peer-reviewedThe study aimed to explore the effects of fortified fermented rice-acid on the antioxidant capacity of mouse serum and the gut microbiota. Hair characteristics, body mass index, intestinal villus height, intestinal crypt depth, serum antioxidant capacity, and gut microbiota of mice were first measured and the correlation between the antioxidant capacity of mouse serum and the gut microbiota was then explored. The mice in the lactic acid bacteria group (L-group), the mixed bacteria group (LY-group), and the rice soup group (R-group) kept their weight well and had better digestion. The mice in the L-group had the better hair quality (dense), but the hair quality in the R-group and the yeast group (Y-group) was relatively poor (sparse). In addition, the inoculation of Lactobacillus paracasei H4-11 (L. paracasei H4-11) and Kluyveromyces marxianus L1-1 (K. marxianus L1-1) increased the villus height/crypt depth of the mice (3.043 ± 0.406) compared to the noninoculation group (R-group) (2.258 ± 0.248). The inoculation of L. paracasei H4-11 and K. marxianus L1-1 in fermented rice-acid enhanced the blood antioxidant capacity of mouse serum (glutathione 29.503 ± 6.604 umol/L, malonaldehyde 0.687 ± 0.125 mmol/L, catalase 15.644 ± 4.618 U/mL, superoxide dismutase 2.292 ± 0.201 U/mL). In the gut microbiota of L-group and LY-group, beneficial microorganisms (Lactobacillus and Blautia) increased, but harmful microorganisms (Candidatus Arthromitus and Erysipelotrichales) decreased. L. paracasei H4-11 and K. marxianus L1-1 might have a certain synergistic effect on the improvement in antibacterial function since they reduced harmful microorganisms in the gut microbiota of mice. The study provides the basis for the development of fortified fermented rice-acid products for regulating the gut microbiota and improving the antioxidant capacity

Twin-field quantum key distribution without phase locking

Twin-field quantum key distribution (TF-QKD) has emerged as a promising solution for practical quantum communication over long-haul fiber. However, previous demonstrations on TF-QKD require the phase locking technique to coherently control the twin light fields, inevitably complicating the system with extra fiber channels and peripheral hardware. Here we propose and demonstrate an approach to recover the single-photon interference pattern and realize TF-QKD \emph{without} phase locking. Our approach separates the communication time into reference frames and quantum frames, where the reference frames serve as a flexible scheme for establishing the global phase reference. To do so, we develop a tailored algorithm based on fast Fourier transform to efficiently reconcile the phase reference via data post-processing. We demonstrate no-phase-locking TF-QKD from short to long distances over standard optical fibers. At 50-km standard fiber, we produce a high secret key rate (SKR) of 1.27 Mbit/s, while at 504-km standard fiber, we obtain the repeater-like key rate scaling with a SKR of 34 times higher than the repeaterless secret key capacity. Our work provides a scalable and practical solution to TF-QKD, thus representing an important step towards its wide applications.Comment: Published versio

Enhanced Solubility and Antitumor Activity of Annona Squamosa Seed Oil via Nanoparticles Stabilized with TPGS: Preparation and In Vitro and In Vivo Evaluation

Annona squamosa seed oil (ASSO), which is a waste product in the extraction of annonaceous acetogenins (ACGs), displays good antitumor activity against a variety of tumor cells. However, ASSO is insoluble and has low bioavailability. In order to improve the solubility and application value of ASSO, the seed oil nanoparticles (ASSO-NPs) were successfully prepared only using TPGS as a stabilizer. ASSO-NPs obtained were spherical with a uniform size (less than 200 nm). ASSO-NPs showed the good storage stability at 25 ± 2 °C and were suitable for both oral administration and intravenous injection. The antitumor study in vitro and in vivo demonstrated more enhanced antitumor efficacy of ASSO-NPs than free ASSO. The ASSO-NPs group (15 mg/kg) had the highest tumor inhibition rate (TIR) of 69.8%, greater than the ASSO solution (52.7%, 135 mg/kg, p < 0.05) in 4T1 tumor-bearing mice. The in vivo biodistribution data displayed that the fluorescence intensity of ASSO/DiR-NPs in tumor was similar to that in liver in the presence of the reticuloendothelial system. Besides, the relative tumor-targeting index (RTTI) of (ACGs + ASSO)-NPs was 1.47-fold that of ACGs delivered alone, and there is great potential in ASSO-NPs as tumor-targeted delivery vehicles. In this study, ASSO-NPs were firstly prepared by a very simple method with fewer excipients, which improved the solubility and antitumor activity of the ASSO, displaying a good prospect in the in vivo delivery of natural bioactive compounds

The mechanisms of hydroxy-α-sanshool from Zanthoxyum bungeanum maxim activates AMPK-HIF1-PKM2 pathway to fix the obesity

To explore effects of hydroxy-α-sanshool (HAS) on metabolism disorder and oxidative stress induced by high-fat diet. The 50 SD male rats were divided into normal group (NC), high-fat group (MC) and HAS groups. Some key indexes, metabolites and signaling molecules were determined. The results showed that compared with MC, HAS significantly reduced body weight, contents of TC, TG, LDL-C, HIF-1, ATP, LDH, CPT and CS in liver; increased activity of SOD and CAT in liver and serum. The identified 7 differential metabolites by UPLC/HRMS were enriched to 18 metabolic pathways including ascorbate metabolism, glutathione metabolism, HIF-1 and glucagon pathway. Furtherly, Western blot showed that increased protein abundance of p-AMPK, p-ACC, Nrf2 and HO-1; reduced that of HIF-1α, p-PKM2 (Tyr105) and CPT1A in HAS groups. It was indicated that HAS activates AMPK-HIF1-PKM2 pathway and Nrf2/HO1 pathway to reduce oxidative damage and improve lipid and energy metabolism disorder caused by high-fat diet

Effects of Hydroxy-Alpha-Sanshool on Intestinal Metabolism in Insulin-Resistant Mice

To explore the hydroxy-alpha-sanshool (HAS) effects on the intestinal metabolites of insulin-resistant mice, the blank group (BG), model group (MG), and HAS dose group (DG) were designed. The insulin resistance (IR) model was induced through streptozotocin (STZ) combined with a high-fat and high-sugar diet. Based on the availability of the model, the HAS dose was given by gavage for 28 days. The determination of cecum and key serum indexes was made, including the contents of insulin (INS), triglycerides (TG), total cholesterol (TC), glycosylated serum protein (GSP), and glycosylated hemoglobin (GHb). The changes in gut microbiota and metabolites in cecal contents were detected by 16S rRNA gene amplicon sequencing and UPLC/HRMS technology, respectively. The results that the levels of GSP, GHb, TG, and TC were significantly increased; this was not the case for INS; or for the changes in the gut microbiota and metabolites in MG. However, the intervention of HAS effectively reversed these changes, for instance, it decreased levels of GSP, GHb, TG, TC, and alterations of metabolite composition for linoleic acid and tyrosine metabolism and recovered trends of declining species diversity and richness of the gut microbiota in MG. It was indicated that HAS alleviated IR by regulating the gut microbiota and metabolites and affecting lipid and amino acid metabolism pathways

Anti-inflammatory effects of chicanine on murine macrophage by down-regulating LPS-induced inflammatory cytokines in IκBα/MAPK/ERK signaling pathways

Schisandra chinensis Baill is a Chinese traditional medicine with multiple pharmacological activities. In this study, chicanine, one of the major lignan compounds of Schiandra chinesis, was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophages (RAW 264.7 cells). Chicanine was found to have anti-infammatory properties with the inhibition of nitric oxide (NO) and Prostaglandin E (2) (PGE2) production and nuclear factor-κB (NF-κB) signaling in LPS-stimulated RAW 264.7 cells with no cytotoxic effects. Treatment of RAW 264.7 cells with chicanine down-regulated LPS-induced expression of pro-inflammatory cytokines including TNFα, IL-1β, MCP-1, G-CSF, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinases 1 and 2 (ERK 1/2), and also IκB-α phosphorylation. These results indicated that anti-inflammatory actions of chicanine in macrophages involved inhibition of LPS-induced TLR4-IκBα/MAPK/ERK signaling pathways