More is simpler : effectively and efficiently assessing node-pair similarities based on hyperlinks

Similarity assessment is one of the core tasks in hyperlink analysis. Recently, with the proliferation of applications, e.g., web search and collaborative filtering, SimRank has been a well-studied measure of similarity between two nodes in a graph. It recursively follows the philosophy that "two nodes are similar if they are referenced (have incoming edges) from similar nodes", which can be viewed as an aggregation of similarities based on incoming paths. Despite its popularity, SimRank has an undesirable property, i.e., "zero-similarity": It only accommodates paths with equal length from a common "center" node. Thus, a large portion of other paths are fully ignored. This paper attempts to remedy this issue. (1) We propose and rigorously justify SimRank*, a revised version of SimRank, which resolves such counter-intuitive "zero-similarity" issues while inheriting merits of the basic SimRank philosophy. (2) We show that the series form of SimRank* can be reduced to a fairly succinct and elegant closed form, which looks even simpler than SimRank, yet enriches semantics without suffering from increased computational cost. This leads to a fixed-point iterative paradigm of SimRank* in O(Knm) time on a graph of n nodes and m edges for K iterations, which is comparable to SimRank. (3) To further optimize SimRank* computation, we leverage a novel clustering strategy via edge concentration. Due to its NP-hardness, we devise an efficient and effective heuristic to speed up SimRank* computation to O(Knm) time, where m is generally much smaller than m. (4) Using real and synthetic data, we empirically verify the rich semantics of SimRank*, and demonstrate its high computation efficiency

State Dependent Delayed Drill-string Vibration : Theory, Experiments and New Model

L.J. Pei would like to acknowledge NNSF of China (No. 11372282) and China Scholarship Council.Peer reviewedPublisher PD

Effectiveness of folic acid fortified flour for prevention of neural tube defects in a high risk region

Despite efforts to tackle folate deficiency and Neural Tube Defects (NTDs) through folic acid fortification, its implementation is still lacking where it is needed most, highlighting the need for studies that evaluate the effectiveness of folic acid fortified wheat flour in a poor, rural, high-risk, NTD region of China. One of the most affected regions, Shanxi Province, was selected as a case study. A community intervention was carried out in which 16,648 women of child-bearing age received fortified flour (eight villages) and a control group received ordinary flour (three villages). NTD birth prevalence and biological indicators were measured two years after program initiation at endline only. The effect on the NTD burden was calculated using the disability-adjusted life years (DALYs) method. In the intervention group, serum folate level was higher than in the control group. NTDs in the intervention group were 68.2% lower than in the control group (OR = 0.313, 95% CI = 0.207-0473, p < 0.001). In terms of DALYs, burden in intervention group was approximately 58.5% lower than in the control group. Flour fortification was associated with lower birth prevalence and burden of NTDs in economically developing regions with a high risk of NTDs. The positive findings confirm the potential of fortification when selecting an appropriate food vehicle and target region. As such, this study provides support for decision makers aiming for the implementation of (mandatory) folic acid fortification in China

Computation of periodic orbits for piecewise linear oscillator by Harmonic Balance Methods

Acknowledgments The authors would like to acknowledge the financial support by NNSF of China (Nos. 11372282 and 10702065) and Scholarship of China; The National Secretariat of Science, Technology and Inno- vation of Ecuador (SENESCYT); The Escuela Superior Politcnica del Litoral of Ecuador (ESPOL).Peer reviewedPostprin

The effects of materialism and ego depletion on intertemporal choice: An event-related potential study

ObjectiveThe study aims to promote human beings to make scientific and reasonable decisions for the long-term and beautiful future.MethodsWe designed two experiments to explore the influence of materialism and ego depletion from the perspective of behavioral decision-making and neural mechanism.ResultsIn Experiment 1, there was asymmetry in intertemporal choice between gain and loss situations. In the gain situation, high materialism were more likely to choose the later and larger option (LL). However, in a loss situation, we found a reverse sign effect, and the proportion of subjects choosing sooner and smaller options (SS) increased. In Experiment 2, in the gain situation, after adding the low ego depletion task, there was a marginal significant difference between high and low materialism in the percentage of choosing LL options, F(1, 40) = 3.37, P = 0.07, η2 = 0.08; After adding the high ego depletion task, the percentage of choosing LL options was no difference, F(1, 40) = 1.42, P &gt; 0.05. In the loss situation, whether in the high ego depletion task [F(1, 40) = 2.25, P &gt; 0.05) or in the low ego depletion task [F(1, 40) = 1.44, P &gt; 0.05), there was no difference between high and low materialism in the percentage of choosing LL options, and they both tended to choose SS options. The EEG study showed that in high materialism, there was a significant difference between the high and low ego depletion conditions, and the N1 amplitude induced under the low ego depletion condition was larger than that under the high ego depletion condition. However, there was no significant difference in N1 amplitude between the high and low ego depletion conditions in the low materialism. The amplitude of P2 evoked in the loss situation was larger than that in the gain situation.ConclusionIn conclusion, Materialism dominated people’s intertemporal choices, and ego depletion affected the intertemporal choice to a certain extent by influencing the subjects’ thinking activities. The COVID-19 epidemic maybe affected intertemporal choice indirectly by acting on materialistic values and subjects’ emotions

BioT5: Enriching Cross-modal Integration in Biology with Chemical Knowledge and Natural Language Associations

Recent advancements in biological research leverage the integration of molecules, proteins, and natural language to enhance drug discovery. However, current models exhibit several limitations, such as the generation of invalid molecular SMILES, underutilization of contextual information, and equal treatment of structured and unstructured knowledge. To address these issues, we propose $\mathbf{BioT5}$, a comprehensive pre-training framework that enriches cross-modal integration in biology with chemical knowledge and natural language associations. $\mathbf{BioT5}$ utilizes SELFIES for $100$ robust molecular representations and extracts knowledge from the surrounding context of bio-entities in unstructured biological literature. Furthermore, $\mathbf{BioT5}$ distinguishes between structured and unstructured knowledge, leading to more effective utilization of information. After fine-tuning, BioT5 shows superior performance across a wide range of tasks, demonstrating its strong capability of capturing underlying relations and properties of bio-entities. Our code is available at $\href{https://github.com/QizhiPei/BioT5}{Github}$.Comment: Accepted by Empirical Methods in Natural Language Processing 2023 (EMNLP 2023

Distinct characteristics and prognosis of IgA nephropathy patients with nephrotic syndrome: a propensity score-matched cohort study

IntroductionIgA nephropathy (IgAN) is the most prevalent primary glomerulonephritis globally. While nephrotic syndrome (NS) is uncommon in IgAN, its significance remains unclear.MethodsWe conducted a retrospective analysis of 170 IgAN patients, classifying them into NS (n = 85) and non-NS (n = 85) groups. Our study aims to compare their clinical characteristics, treatment responses, and prognoses. Patients were selected based on renal biopsy from 2003 to 2020. Propensity score matching ensured comparability. Clinical, pathological, and immunological data were analyzed. Composite endpoints were defined as end-stage kidney disease (ESKD) or a 30% decline in estimated glomerular filtration rate (eGFR).ResultsNS patients showed higher eGFR (74.3 ± 36.8 vs. 61.5 ± 33.6 mL/min.1.73 m2, p = 0.02), severe hematuria (35.0 (4.7,147.5) vs. 4.0 (1.8,45,0) cells/μl, p &lt; 0.001), severe foot process effacement (p = 0.01), and lower C3 levels (1.0 ± 0.3 vs. 1.1 ± 0.2 g/L, p = 0.03). In contrast, the non-NS group had higher BMI (24.3 ± 4.0 vs. 26.8 ± 3.7 kg/m2, p &lt; 0.001) and elevated serum uric acid levels (376 (316,417) vs. 400 (362, 501) mmol/L, p = 0.001), suggesting metabolic factors might contribute to their condition. Both groups exhibited similar MESTC scores. NS patients had higher complete remission rates (26.2% vs. 14.1%, p = 0.04). Cox regression revealed NS independently associated with a higher risk of composite endpoints (HR = 1.97, 95% CI 1.05–3.72, p = 0.04). Linear mixed models did not show significant eGFR trajectory differences.DiscussionThis study has established that IgAN patients with NS exhibit distinct characteristics, including active disease and increased complement activation. NS is independently associated with a poorer prognosis, emphasizing the need for targeted interventions in this subgroup

Discovering the link between IL12RB1 gene polymorphisms and tuberculosis susceptibility: a comprehensive meta-analysis

IntroductionNumerous studies suggest that the risk of tuberculosis (TB) is linked to gene polymorphisms of the interleukin-12 receptor b subunit 1 (IL12RB1), but the association between IL12RB1 polymorphisms and TB susceptibility has not been thoroughly investigated.MethodsA meta-analysis was conducted based on eight case-control studies with 10,112 individuals to further explore this topic. A systematic search of PubMed, Web of Science, Excerpt Medica Database, and Google Scholar up until April 6th, 2023 was performed. ORs and 95% CIs were pooled using the random-effect model. The epidemiological credibility of all significant associations was assessed using the Venice criteria and false-positive report probability (FPRP) analyses.ResultsThe IL12RB1 rs11575934 and rs401502 showed solid evidence of no significant association with TB susceptibility. However, a weak association was observed between the IL12RB1 rs375947 biomarker and pulmonary tuberculosis (PTB) susceptibility (OR = 1.64, 95% CI: 1.22, 2.21).DiscussionThese findings should be confirmed through larger, better-designed studies to clarify the relationship between biomarkers in IL12RB1 gene and different types of TB susceptibility