C–H Hydroxylation of Phosphonates with Oxygen in [bmIm]OH To Produce Quaternary α‑Hydroxy Phosphonates

A highly efficient and mild [bmIm]­OH-catalyzed α-hydroxylation of phosphonates using O₂ as the oxygen source is described. The employment of ionic liquid under mild reaction conditions makes this transformation green and practical. Especially, this reaction provided a novel and convenient methodology for the construction of quaternary α-hydroxy phosphonates

Copper-Catalyzed Aerobic Oxidative Cleavage of C–C Bonds in Epoxides Leading to Aryl Ketones

A novel copper-catalyzed aerobic synthesis of ketones from epoxides via cleavage of C–C single bonds has been discovered. This reaction constitutes a new transformation from epoxides into ketones

Forest plot for the association of NF-κB with clinicopathological parameters.

<p>(A) Patients with adenocarcinoma and squamous cell carcinoma. (B) Patients with tumor stage T1/T2 and T3/T4. (C) Patients with or without lymph node metastasis. OR, Odds ratio; CI, confidence interval.</p

Flow illustration for studies selection process.

<p>Flow illustration for studies selection process.</p

Forest plot for the association between NF-κB and overall survival in NSCLC patients.

<p>(A) Overall analysis of all NSCLC patients. (B) Subgroup analysis of Asian and Caucasian NSCLC patients. HR, hazard ratio; CI, confidence interval.</p

Main characteristics of included studies in the meta-analysis.

<p>Main characteristics of included studies in the meta-analysis.</p

Forest plot for the expression levels of NF-kB family members and 5-year overall survival in NSCLC patients.

<p>Forest plot for the expression levels of NF-kB family members and 5-year overall survival in NSCLC patients.</p

Sensitivity analyses.

<p>(A) Overall survival in NSCLC patients. (B) Tumor stage. (C) Lymph node metastasis.</p

Comparison of the results between sequencing and PCR-SSOP-Luminex assay.

<p>Comparison of the results between sequencing and PCR-SSOP-Luminex assay.</p

Validation of PCR-SSOP-Luminex assay using plasmids as templates.

<p>(A) Agarose gel electrophoresis of amplified fragments. Lanes 1–6: Fragment a (547 bp). Lanes 7–14: Fragment c (512 bp). 1, wild type; 2, M41L-TTG; 3, M41L-CTG; 4, K65R-AGA; 5, 70R-AGA; 6, 70R-AGG; 7, wild type; 8, 103N-AAC; 9, K103N-AAT; 10, M184V-GTG; 11, T215Y-TAC; 12, T215F-TTC. (B) Median fluorescence intensities (MFIs). The plasmid in the test sample is indicated on the top of each panel. Oligoprobes used for detection are indicated at the bottom. Matched results are shown as black bars, mismatched results as white bars. Assays were performed in triplicate. The mean ± standard deviation is shown at the top of each bar.</p