GIS-Based Analysis of the Spatial Distribution and Influencing Factors of Traditional Villages in Hebei Province, China

Traditional villages are a valuable cultural asset that occupy an important position in Chinese traditional culture. This study focuses on 206 traditional villages in Hebei Province, and aims to explore their spatial distribution characteristics and influencing factors using ArcGIS spatial analysis. The analysis shows that traditional villages in Hebei Province were distributed in clus-ters during different historical periods, and eventually formed three core clusters in Shijiazhuang, Zhangjiakou and Xingtai-Handan after different historical periods. Moreover, the overall dis-tribution of traditional villages in Hebei Province is very uneven, with clear regional differences, and most of them are concentrated in the eastern foothills of the Taihang Mountains. To identify the factors influencing traditional villages, natural environmental factors, socio-economic factors, and historical and cultural factors are considered. The study finds that socio-economic and nat-ural environmental factors alternate in the spatial distribution of traditional villages in Hebei Province. The influence of the interaction of these factors increases significantly, and so-cio-economic factors have a stronger influence on the spatial distribution. Specifically, the spatial distribution of traditional villages in Hebei Province is influenced by natural environmental fac-tors, while socio-economic factors act as drivers of spatial distribution. Historical and cultural factors act as catalysts of spatial distribution, and policy directions are external forces of spatial distribution. Overall, this study provides valuable insights into the spatial distribution charac-teristics and influencing factors of traditional villages in Hebei Province, which can be used to develop effective strategies for rural revitalisation in China

Interaction-free, single-pixel quantum imaging with undetected photons

A typical imaging scenario requires three basic ingredients: 1. a light source that emits light, which in turn interacts and scatters off the object of interest; 2. detection of the light being scattered from the object and 3. a detector with spatial resolution. These indispensable ingredients in typical imaging scenarios may limit their applicability in the imaging of biological or other sensitive specimens due to unavailable photon-starved detection capabilities and inevitable damage induced by interaction. Here, we propose and experimentally realize a quantum imaging protocol that alleviates all three requirements. By embedding a single-photon Michelson interferometer into a nonlinear interferometer based on induced coherence and harnessing single-pixel imaging technique, we demonstrate interaction-free, single-pixel quantum imaging of a structured object with undetected photons. Thereby, we push the capability of quantum imaging to the extreme point in which no interaction is required between object and photons and the detection requirement is greatly reduced. Our work paves the path for applications in characterizing delicate samples with single-pixel imaging at silicon-detectable wavelengths

Evolution of T-cell clonality in a patient with Ph-negative acute lymphocytic leukemia occurring after interferon and imatinib therapy for Ph-positive chronic myeloid leukemia

<p>Abstract</p> <p>Introduction</p> <p>The development of Philadelphia chromosome (Ph) negative acute leukemia/myelodysplastic syndrome (MDS) in patients with Ph-positive chronic myeloid leukemia (CML) is very rare. The features of restrictive usage and absence of partial T cell clones have been found in patients with CML. However, the T-cell clonal evolution of Ph-negative malignancies during treatment for CML is still unknown.</p> <p>Objective</p> <p>To investigate the dynamic change of clonal proliferation of T cell receptor (TCR) Vα and Vβ subfamilies in one CML patient who developed Ph-negative acute lymphoblastic leukemia (ALL) after interferon and imatinib therapy.</p> <p>Methods</p> <p>The peripheral blood mononuclear cells (PBMC) samples were collected at the 3 time points (diagnosis of Ph-positive chronic phase (CP) CML, developing Ph-negative ALL and post inductive chemotherapy (CT) for Ph-negative ALL, respectively). The CDR3 size of TCR Vα and Vβ repertoire were detected by RT-PCR. The PCR products were further analyzed by genescan to identify T cell clonality.</p> <p>Results</p> <p>The CML patient who achieved complete cytogenetic remission (CCR) after 5 years of IFN-α therapy suddenly developed Ph-negative ALL 6 months following switch to imatinib therapy. The expression pattern and clonality of TCR Vα/Vβ T cells changed in different disease stages. The restrictive expression of Vα/Vβ subfamilies could be found in all three stages, and partial subfamily of T cells showed clonal proliferation. Additionally, there have been obvious differences in Vα/Vβ subfamily of T cells between the stages of Ph-positive CML-CP and Ph-negative ALL. The Vα10 and Vβ3 T cells evolved from oligoclonality to polyclonality, the Vβ13 T cells changed from bioclonality to polyclonality, when Ph-negative ALL developed.</p> <p>Conclusions</p> <p>Restrictive usage and clonal proliferation of different Vα/Vβ subfamily T cells between the stages of Ph-positive CP and Ph-negative ALL were detected in one patient. These changes may play a role in Ph- negative leukemogenesis.</p

Study of indium tin oxide thin films deposited on acrylics substrates by Ion beam assisted deposition technique

Indium tin oxide (ITO) thin films have been deposited onto acrylics (PMMA) substrates by ion beam assisted deposition technique at different oxygen flows. The structural, optical and electrical properties of the deposited films have been characterized by X-ray diffraction, transmittance, FTIR, ellipometry and Hall effect measurements. The optical constants of the deposited films have been calculated by fitting the ellipsometric spectra. The effects of the oxygen flow on the properties of the deposited films have been studied. It has been found that 40 sccm oxygen flow is an optimum value for getting the films with good transmittance and low electrical resistivity

A detailed study on the Fe-doped TiO2 thin films induced by pulsed laser deposition route

Fe-doped TiO2 thin films are deposited both on the (1 0 0) oriented Si and glass substrates by pulsed laser deposition technique using Fe powder doped TiO2 ceramic target. The structural and optical properties of the film have been studied in detail. The degree of film crystallinity is investigated by X-ray diffraction and confirmed by Raman scattering measurements. The stoichiometry and chemical states of Fe, Ti and O are probed by X-ray photoelectron spectroscopy. The surface morphologies are observed by Scanning electron microscopy. The optical properties are studied by measuring the transmittance and the optical constants, the refractive index and the extinction coefficient. It is found that the substrate temperature is a key factor in determining the thin film structure which further influences the refractive index and the optical band gap of the film. An anatase structure emerges above 300 °C while the rutile structure appears when the substrate temperature is higher than 500 °C. Another result is that Fe exists in the deposited films as Fe3+ and the atomic concentration of Fe in the films is much lower than that in the source target.publishe

Overexpressed transient receptor potential vanilloid 1 (TRPV1) in lung adenocarcinoma harbours a new opportunity for therapeutic targeting

The specific biological function of transient receptor potential vanilloid 1 (TRPV1) in pathogenesis of lung adenocarcinoma (LUAD) remains unclear. In this study, TRPV1 expression in tumor tissues, primary cells and cell lines of LUAD, as well as the mechanism mediating its hyperexpression were systematically studied. Multiple models and techniques were adopted to elucidate the relationship between TRPV1 hyperexpression and tumor recurrence and metastasis. Results showed that TRPV1 expression was increased in tumor tissues and primary tumor cells of LUAD patients. The increased expression was associated with worse overall survival outcome and raised HIF1α levels. TRPV1 expression in A549 and NCI-H292 cells was increased after pretreatment with cigarette smoke extract or spermine NONOate. Moreover, A549 cells with TRPV1 overexpression has enhanced tumor growth rates in subcutaneous grafted tumor models, and increased intrapulmonary metastasis after tail vein infusion in nude BALB/c nude mice. Mechanistically, TRPV1 overexpression in A549 cells promoted HIF1α expression and nuclear translocation by promoting CREB phosphorylation and activation of NOS1-NO pathway, ultimately leading to accelerated cell proliferation and stronger invasiveness. In addition, based on photothermal effects, CuS-TRPV1 mAb effectively targeted and induced apoptosis of TRPV1-A549 cells both in vivo and in vitro, thereby mitigating tumor growth and metastasis induced by xenotransplantation of TRPV1-A549 cells. In conclusion, TRPV1 hyperexpression in LUAD is a risk factor for tumor progression and is involved in proliferation and migration of tumor cells through activation of HIF1α. Our study also attempted a new strategy inhibiting the recurrence and metastasis of LUAD: by CuS-TRPV1 mAb precisely kill TRPV1 hyperexpression cells through photothermal effects