A genome-wide association study of coat color in Chinese Rex rabbits

Coat color is an important phenotypic characteristic of the domestic rabbit (Oryctolagus cuniculus) and has specific economic importance in the Rex rabbit industry. Coat color varies considerably among different populations of rabbits, and several causal genes for this variation have been thoroughly studied. Nevertheless, the candidate genes affecting coat color variation in Chinese Rex rabbits remained to be investigated. In this study, we collected blood samples from 250 Chinese Rex rabbits with six different coat colors. We performed genome sequencing using a restriction site-associated DNA sequencing approach. A total of 91,546 single nucleotide polymorphisms (SNPs), evenly distributed among 21 autosomes, were identified. Genome-wide association studies (GWAS) were performed using a mixed linear model, in which the individual polygenic effect was fitted as a random effect. We detected a total of 24 significant SNPs that were located within a genomic region on chromosome 4 (OCU4). After re-fitting the most significant SNP (OCU4:13,434,448, p = 1.31e-12) as a covariate, another near-significant SNP (OCU4:11,344,946, p = 7.03e-07) was still present. Hence, we conclude that the 2.1-Mb genomic region located between these two significant SNPs is significantly associated with coat color in Chinese Rex rabbits. The well-studied coat-color-associated agouti signaling protein (ASIP) gene is located within this region. Furthermore, low genetic differentiation was also observed among the six coat color varieties. In conclusion, our results confirmed that ASIP is a putative causal gene affecting coat color variation in Chinese Rex rabbits

What Do MBA Program in Southeast Asia Scholars Propose for Future COVID-19 Research in Academic Publications? A Topic Analysis Based on Autoencoder

To analyze the directions for future research suggested and to project future research plans, we extract relevant text from these publications with respect to COVID-19-related research based on 54,136 relevant academic journals published from the initial outbreak of COVID-19 in January 2020 until December 2020. First, we extract and preprocess the corpus and then determine that, according to the Elbow method, the optimal number of clusters is 7. Then, we construct a text clustering model based on an autoencoder, with the support of an artificial neural network. Distance measurements, such as correlation, cosine, Braycurtis, and Jaccard are compared, and the clustering results are evaluated with normal mutual information. The results show that cosine similarity has the best effect on clustering of COVID-19-related documents. A topic model analysis shows that the directions of future research can mainly be grouped into the following seven categories: infectivity testing, genome analysis, vaccine testing, diagnosis and infection characteristics, pandemic management, nursing care, and clinical testing. Among them, the topics of pandemic management, diagnosis and infection characteristics, and clinical testing trended upward in proportion to future directions. The topic of vaccine testing remains steady over the observation window, whereas other topics (infectivity testing, genome analysis, and nursing care) slowly trended downward. Among all the topics, medical research comprises 80%, and about 20% of the topics are related to public management, government functions, and economic development. This study enriches our scientific understanding of COVID-19 and helps us to effectively predict future scientific research output on COVID-19

Distance Diffusion of Home Bias for Crowdfunding Campaigns between Categories: Insights from Data Analytics

As the information communication and investment of crowdfunding campaigns are usually accomplished online, online crowdfunding theoretically breaks the limitation of space. However, investors’ behaviors still show significant home bias; furthermore, from a dynamic view, the changes in home bias during the funding duration reflect the investment preference. This paper studies the dynamics of home bias in crowdfunding investment as well as the distance diffusion of home bias in the crowdfunding market through data mining and econometric models. The distance between investors and founders gradually increases from 3605 km to 4229 km as the funding progresses, and home bias shows different diffusion patterns between categories. For most of the campaigns, the distance between backers and founders of the successful campaigns is always greater than that of the failed ones; thus, the distance diffusion impacts the pledge results. However, the study also finds that for some categories, home bias does not play a positive role in investment or that it even shows negative impacts, among which food and technology are two extreme categories. The study provides a theoretical basis from the perspective of user behavior to analyze online investment and to improve the promotion of crowdfunding campaigns

How much do social connections matter in fundraising outcomes?

10.1186/s40854-021-00293-7Financial Innovation717

Effect of Special-Shaped Nozzle Structure on Water Jet Performance

The impact force and effective impact area of are water jet are two important indexes for evaluating jet performance, and the outlet shape of the nozzle has a great influence on jet performance. In this study, five nozzles with different outlet shapes were designed, and water jet test experiments were conducted at different inlet pressures using an independently built water jet impact test platform, and the influence law of nozzle shape on the center impact pressure and flow coefficient of the water jet was investigated. The influence of nozzle shape on the effective impact area and entrainment rate of water jet was further investigated by numerical simulation. The results showed that the center impact pressure of the circular nozzle was the greatest when the inlet pressure and the target distance were small. The center impact pressure, the flow coefficient, and the effective area of the triangular nozzle with sharp edges were better than the traditional circular nozzle when the inlet pressure and the target distance were increased. Although the center impact pressure of the square nozzle is lower than that of the circular nozzle, its flow coefficient and effective impact area are higher than those of the circular nozzle with increasing target distance. The water jets of the elliptical and cross nozzles were the most divergent, and the jet performance was poor

Design and Optimization of High-Pressure Water Jet for Coal Breaking and Punching Nozzle Considering Structural Parameter Interaction

The technology of increasing coal seam permeability by high-pressure water jet has significant advantages in preventing and controlling gas disasters in low-permeability coal seam. The structural parameters of a nozzle are the key to its jet performance. The majority of the current studies take strike velocity as the evaluation index, and the influence of the interaction between the nozzle’s structural parameters on its jet performance is not fully considered. In practice, strike velocity and strike area will affect gas release in the process of coal breaking and punching. To further optimize the structural parameters of coal breaking and punching nozzle, and improve water jet performance, some crucial parameters such as the contraction angle, outlet divergence angle, and length-to-diameter ratio are selected. Meanwhile, the maximum X-axis velocity and effective Y-axis extension distance are used as evaluation indexes. The effect of each key factor on the water jet performance is analyzed by numerical simulation using the single factor method. The significance and importance effect of each factor and their interaction on the water jet performance are quantitatively analyzed using the orthogonal experiment method. Moreover, three optimal combinations are selected for experimental verification. Results show that with an increase in contraction angle, outlet divergence angle, and length-to-diameter ratio, the maximum X-axis velocity increases initially and decreases thereafter. The Y-direction expansion distance of the jet will be improved significantly with an increase in the outlet divergence angle. Through field experiments, the jet performance of the improved nozzle 3 is the best. After optimization, the coal breaking and punching diameter of the nozzle is increased by 118%, and the punching depth is increased by 17.46%

Design and Optimization of High-Pressure Water Jet for Coal Breaking and Punching Nozzle Considering Structural Parameter Interaction

The technology of increasing coal seam permeability by high-pressure water jet has significant advantages in preventing and controlling gas disasters in low-permeability coal seam. The structural parameters of a nozzle are the key to its jet performance. The majority of the current studies take strike velocity as the evaluation index, and the influence of the interaction between the nozzle’s structural parameters on its jet performance is not fully considered. In practice, strike velocity and strike area will affect gas release in the process of coal breaking and punching. To further optimize the structural parameters of coal breaking and punching nozzle, and improve water jet performance, some crucial parameters such as the contraction angle, outlet divergence angle, and length-to-diameter ratio are selected. Meanwhile, the maximum X-axis velocity and effective Y-axis extension distance are used as evaluation indexes. The effect of each key factor on the water jet performance is analyzed by numerical simulation using the single factor method. The significance and importance effect of each factor and their interaction on the water jet performance are quantitatively analyzed using the orthogonal experiment method. Moreover, three optimal combinations are selected for experimental verification. Results show that with an increase in contraction angle, outlet divergence angle, and length-to-diameter ratio, the maximum X-axis velocity increases initially and decreases thereafter. The Y-direction expansion distance of the jet will be improved significantly with an increase in the outlet divergence angle. Through field experiments, the jet performance of the improved nozzle 3 is the best. After optimization, the coal breaking and punching diameter of the nozzle is increased by 118%, and the punching depth is increased by 17.46%