The Role of IL-33 in Rheumatic Diseases

Interleukin-33 (IL-33), a novel member of IL-1 family, has been recently implicated in several inflammatory and autoimmune diseases. IL-33 can be produced by various types of tissues and cells and induce gene expression of Th2-associated cytokines via binding to the orphan receptor ST2. By promoting Th2 type immune response, IL-33 plays important roles in the allergy, whereas its function in autoimmune diseases attracts more attention. Recent studies reported the correlation of IL-33 with rheumatic diseases, and most of them found that the IL-33 expression levels were consistent with disease activity and development. Furthermore, evidence has indicated that IL-33-related treatment may ameliorate the pathogenic conditions and attenuate disease progression of those rheumatic diseases. Therefore, elucidation of the roles of IL-33 in rheumatic diseases would be beneficial to understand the pathogenesis and therapy of these diseases. In this paper, we will summarize the roles of IL-33 in the rheumatic diseases

Zigzag graphene nanoribbons without inversion symmetry

Graphene on a substrate will suffer an inversion-symmetry-breaking (ISB) lattice potential. Taking electron-electron interaction into account, we study in this paper the possibility of half-metallicity and noncollinear (NC) magnetic phase for graphene zigzag nanoribbons without inversion symmetry. At half-filling it is found that half-metallic(HM) state can be achieved at an intermediate value of the ISB potential due to its competition with the electron-electron interaction. Away from half-filling, the phase diagrams of doping versus ISB potential for different ribbon width are given, where the regimes for the HM states and NC magnetic state are clearly indicated and discussed. For ribbons with perfect edges, we predict a topological transition between two HM states with different magnetic structures, which is accompanied by an abrupt transition of electrical conductance along the ribbon from $2e^2/h$ to $e^2/h$.Comment: 7 pages, 7 figure

Hybrid Chaplygin gas and phantom divide crossing

Hybrid Chaplygin gas model is put forward, in which the gases play the role of dark energy. For this model the coincidence problem is greatly alleviated. The effective equation of state of the dark energy may cross the phantom divide $w=-1$. Furthermore, the crossing behaviour is decoupled from any gravity theories. In the present model, $w<-1$ is only a transient behaviour. There is a de Sitter attractor in the future infinity. Hence, the big rip singularity, which often afflicts the models with matter whose effective equation of state less than -1, is naturally disappear. There exist stable scaling solutions, both at the early universe and the late universe. We discuss the perturbation growth of this model. We find that the index is consistent with observations.Comment: 11 pages, 4 figures, V3: discussions on the perturbation growth added, V4: minor corrections, to match the published versio

4-[(2-Chloro-4-nitro­phen­yl)diazen­yl]-N,N-diethyl­aniline

In the title compound, C16H17ClN4O2, the aromatic ring is twisted slightly with respect to the plane of the diazene group [N—N—C—C torsion angle = −3.9 (4)°]. The NO2 group is twisted by 16.2 (4)° relative to the aromatic ring. The two ethyl chains are positioned such that one ethyl chain lies above and the other below the ring

Wealth Inequality and Mental Disability Among the Chinese Population: A Population Based Study

In the study described herein, we investigated and explored the association between wealth inequality and the risk of mental disability in the Chinese population. We used nationally represented, population-based data from the second China National Sample Survey on Disability, conducted in 2006. A total of 1,724,398 study subjects between the ages of 15 and 64, including 10,095 subjects with mental disability only, were used for the analysis. Wealth status was estimated by a wealth index that was derived from a principal component analysis of 10 household assets and four other variables related to wealth. Logistic regression analysis was used to estimate the odds ratio (OR) and 95% confidence interval (CI) for mental disability for each category, with the lowest quintile category as the referent. Confounding variables under consideration were age, gender, residence area, marital status, ethnicity, education, current employment status, household size, house type, homeownership and living arrangement. The distribution of various types and severities of mental disability differed significantly by wealth index category in the present population. Wealth index category had a positive association with mild mental disability (p for trend <0.01), but had a negative association with extremely severe mental disability (p for trend <0.01). Moreover, wealth index category had a significant, inverse association with mental disability when all severities of mental disability were taken into consideration. This study’s results suggest that wealth is a significant factor in the distribution of mental disability and it might have different influences on various types and severities of mental disability

A secure cross-domain authentication scheme based on threshold signature for MEC

The widespread adoption of fifth-generation mobile networks has spurred the rapid advancement of mobile edge computing (MEC). By decentralizing computing and storage resources to the network edge, MEC significantly enhances real-time data access services and enables efficient processing of large-scale dynamic data on resource-limited devices. However, MEC faces considerable security challenges, particularly in cross-domain service environments, where every device poses a potential security threat. To address this issue, this paper proposes a secure cross-domain authentication scheme based on a threshold signature tailored to MEC’s multi-subdomain nature. The proposed scheme employs a (t,n) threshold mechanism to bolster system resilience and security, catering to large-scale, dynamic, and decentralized MEC scenarios. Additionally, the proposed scheme features an efficient authorization update function that facilitates the revocation of malicious nodes. Security analysis confirmed that the proposed scheme satisfies unforgeability, collusion resistance, non-repudiation and forward security. Theoretical evaluation and experimental simulation verify the effectiveness and feasibility of the proposed scheme. Compared with existing schemes, the proposed scheme has higher computational performance while implementing secure authorization updates

Entanglement Perturbation Theory for Infinite Quasi-1D Quantum Systems

We develop Entanglement Perturbation Theory (EPT) for infinite Quasi-1D quantum systems. The spin 1/2 Heisenberg chain with ferromagnetic nearest neighbor (NN) and antiferromagnetic next nearest neighbor (NNN) interactions with an easy-plane anisotropy is studied as a prototypical system. The obtained accurate phase diagram is compared with a recent prediction [Phys.Rev.B,81,094430(2010)] that dimer and Neel orders appear alternately as the XXZ anisotropy Delta approaches the isotropic limit Delta=1. The first and second transitions (across dimer, Neel, and dimer phases) are detected with improved accuracy at Delta\approx 0.722 and 0.930. The third transition (from dimer to Neel phases), previously predicted to be at Delta\approx 0.98, is not detected at this Delta in our method, raising the possibility that the second Neel phase is absent.Comment: 5 pages, 5 figure

Entanglement perturbation theory for the elementary excitation in one dimension

The entanglement perturbation theory is developed to calculate the excitation spectrum in one dimension. Applied to the spin-$\frac{1}{2}$ antiferromagnetic Heisenberg model, it reproduces the des Cloiseaux-Pearson Bethe ansatz result. As for spin-1, the spin-triplet magnon spectrum has been determined for the first time for the entire Brillouin zone, including the Haldane gap at $k=\pi$

Auxin response factor 6A regulates photosynthesis, sugar accumulation, and fruit development in tomato.

Auxin response factors (ARFs) are involved in auxin-mediated transcriptional regulation in plants. In this study, we performed functional characterization of SlARF6A in tomato. SlARF6A is located in the nucleus and exhibits transcriptional activator activity. Overexpression of SlARF6A increased chlorophyll contents in the fruits and leaves of tomato plants, whereas downregulation of SlARF6A decreased chlorophyll contents compared with those of wild-type (WT) plants. Analysis of chloroplasts using transmission electron microscopy indicated increased sizes of chloroplasts in SlARF6A-overexpressing plants and decreased numbers of chloroplasts in SlARF6A-downregulated plants. Overexpression of SlARF6A increased the photosynthesis rate and accumulation of starch and soluble sugars, whereas knockdown of SlARF6A resulted in opposite phenotypes in tomato leaves and fruits. RNA-sequence analysis showed that regulation of SlARF6A expression altered the expression of genes involved in chlorophyll metabolism, photosynthesis and sugar metabolism. SlARF6A directly bound to the promoters of SlGLK1, CAB, and RbcS genes and positively regulated the expression of these genes. Overexpression of SlARF6A also inhibited fruit ripening and ethylene production, whereas downregulation of SlARF6A increased fruit ripening and ethylene production. SlARF6A directly bound to the SAMS1 promoter and negatively regulated SAMS1 expression. Taken together, these results expand our understanding of ARFs with regard to photosynthesis, sugar accumulation and fruit development and provide a potential target for genetic engineering to improve fruit nutrition in horticulture crops