768 research outputs found

    Developing A Sustainable AoL Framework Using Supply Chain Principles

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    Many accreditation agencies have adopted Assurance of Learning (AoL)-based paradigms for assessing educational institutions. Colleges/universities transitioning to an Assurance of Learning (AoL) system encounter common challenges while implementing new standards. In this research, the authors develop a stakeholder driven AoL framework which addresses common transitional issues while maintaining the Southern Association of Colleges and Schools (SACS) and Association to Advance Collegiate Schools of Business (AACSB) accreditation standards. The model incorporates supply chain practices by best in class (BIC) companies to optimize overall assessment efforts. The model decreases the number of redundant processes, improves collaboration throughout the university, and promotes a more comprehensive curriculum. After the model implementation, the authors examine mission statements and tenure, promotion and reappointment documents to gain insight about how to sustain accreditation

    The Mosaic Law

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    In recent years much has been learned of the civilization, which developed in early times in Mesopotamia. In Babylon, laws appropriate to a vast and wealthy agricultural nation, which was engaged, also, largely in commerce, had been developed many centuries before the authentic history of other peoples begins. This civilization was Semitic. A great light, where formerly but dim reflections had been seen, was thrown upon this jurisprudence by the discovery, in 1901, of the codification of the laws of Babylonia, which was promulgated by King Hammurabi about 2350 B. C. Migration from Babylonia occurred from time to time, and settlements were early made in the countries bordering on the Mediterranean. The Canaanites of the Bible were descendants of such immigrants. Likewise, perhaps before 1500 B. C., a clan or family (being the Biblical Abraham), left Ur of the Chaldees (situated in the Euphrates valley), and migrated southwesterly. Pursuing a pastoral life, they multiplied and later settled in Egypt, where they became subject to the ruling power. About 1200 B. C., they freed themselves from the Egyptian bondage, and, under the leadership of their great prophet, Moses, led a nomadic life for some years in the deserts of Arabia

    Administering Justice the Medical Prepossession

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    This quotation is from a recent document coming from con- servative and intelligent sources, recommending as a cure for economic and commercial unrest, and other evils, the creation of a League of National Guilds

    Economic Aspects of the Law of Master and Servant, in its Relation to Industrial Accidents

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    We hear it said frequently that the relations between master and servant have completely altered during the past century and that, due to the introduction of machinery, workmen are much more frequently and more seriously injured than formerly. In fact, these statements have become trite. It takes an article, such as that written by Arthur B. Reeve, in the February, 1907, number of Charities and the Commons, entitled The Death Roll of Industry, to bring to our minds what these statements actually mean; to impress us with the seriousness of present conditions. Although statistics upon the matter are not as satisfactory as Mr. Reeve would wish, yet the conclusions at which he arrives seem to be conservative, viz., that, during the year 190 out of a total of l,382,196 employees upon the railroads of the country, there were either killed or injured a total of 70,194; in other words, substantially one out of every twenty railroad employees was either killed or maimed. Also, that, in the aggregate, more than half a million workmen have been killed or injured during the year 1905 in other words, that some servant, as a result of his employment, is either killed or injured every minute of time, counting nights and Sundays

    The Fetal Allograft Revisited: Does the Study of an Ancient Invertebrate Species Shed Light on the Role of Natural Killer Cells at the Maternal-Fetal Interface?

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    Human pregnancy poses a fundamental immunological problem because the placenta and fetus are genetically different from the host mother. Classical transplantation theory has not provided a plausible solution to this problem. Study of naturally occurring allogeneic chimeras in the colonial marine invertebrate, Botryllus schlosseri, has yielded fresh insight into the primitive development of allorecognition, especially regarding the role of natural killer (NK) cells. Uterine NK cells have a unique phenotype that appears to parallel aspects of the NK-like cells in the allorecognition system of B. schlosseri. Most notably, both cell types recognize and reject "missing self" and both are involved in the generation of a common vascular system between two individuals. Chimeric combination in B. schlosseri results in vascular fusion between two individual colonies; uterine NK cells appear essential to the establishment of adequate maternal-fetal circulation. Since human uterine NK cells appear to de-emphasize primary immunological function, it is proposed that they may share the same evolutionary roots as the B. schlosseri allorecognition system rather than a primary origin in immunity

    Intramolecular Exciton Coupling and Induced Circular Dichroism From Bilirubin-Ephedrine Heteroassociation Complexes. Stereochemical Models for Protein Binding

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    Bichromophoric (4Z,15Z)-bilirubin-IXa, the cytotoxic and yel-: low-orange pigment of jaundice, prefers to adopt either of two enantiomeric intramolecularly hydrogeri-bonded conformations that are in dynamic equilibrium in solution. In the presence of optically active amino-alcohols, particularly ephedrines, the pigment solutions exhibit intense bisignate circular dichroism in the region of the bilirubin long wavelength UV-visible absorption band. The most intense circular dichroism Cotton effects, I !\u27lE; i --+ 200, are induced by O-methylephedrines, exceeding even those generally exhibited by bilirubin complexes with serum albumin and other proteins. Like serum albumin and other proteins, the optically active amino alcohols act as chiral templates, inducing an asymmetric transformation of bilirubin, whose induced bisignate circular dichroism Cotton effect originate from exciton sphtting of its two component pyrromethenone chromophores. The amines are thought to serve as agents for chiral molecular recognitlon by forming .diastereorneric salts with the pigment. And the complementary action of fJ-aryl and proximal hydroxyl and methoxyl group s provides insight into the binding forces important in bilirubinprotein binding

    Linguistics

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    Contains reports on three research projects.National Science Foundation (Grant GP-2495)National Institutes of Health (Grant MH-04737-04)U. S. Air Force. Electronics Systems Division (Contract AFl9(628)-2487)National Aeronautics and Space Administration (Grant NsG-496

    Vibrational Circular Dichroism Detects Symmetry Breaking due to Conformational Mobility in C2-Symmetry Chiral Molecules and Provides Further Insight into Inter-Chromophoric Interactions

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    Bicyclo[3.3.1]nonane-2,6-dione (1) and bicyclo[3.3.1]nona-3,7-diene-2,6-dione (2) have been examined by vibrational circular dichroism (VCD), which, as for most C2-symmetric systems, exhibits strong VCD signals. In the case of 2, VCD signals are stronger and sharper with several bisignate doublets; for 1, signals are less intense and broader. The VCD and IR spectra are excellently predicted by DFT calculations: only one conformer is present for 2, while for 1, three main conformers, related through concerted skeleton torsional motions are present (two of them being interchanged by C2-rotation). The VCD spectrum shows specific features for the different conformers, such that correct population factors are crucial for reproducing experimental data. Also, the TD-DFT prediction of ECD (electronic circular dichroism) spectra is good. By comparing the spectroscopic signature of the two molecules (both VCD and ECD) and by careful analysis of the theoretical results, the role of the C=C double bond in compound (2) is evidenced. The double bond contributes toward enhancing the CD response both electronically and vibrationally

    Localization of tenascin in human skin wounds

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    A total of 56 surgically treated human skin wounds with a wound age between 8h and 7 months were investigated. Tenascin was visualized by immunohistochemistry and appeared first in the wound area pericellularly around fibroblastic cells approximately 2 days after wounding. A network-like interstitial positive staining pattern was first detectable in 3-day-old skin wounds. In all wounds with an age of 5 days or more, intensive reactivity for tenascin could be observed in the lesional area (dermal-epidermal junction, wound edge, areas of bleeding). In wounds with an age of more than approximately 1.5 months no positive staining occurred in the scar tissue. In conclusion, for forensic purposes, positive staining for tenascin restricted to the pericellular area of fibroblastic cells indicates a wound age of at least 2 days. Network-like structures appear after approximately 3 days or more. Since tenascin seems to be regularly detectable in skin wounds older than 5 days, the lack of a positive reaction in a sufficient number of specimens indicates a wound age of less than 5 days. The lack of a positive reaction in the granulation tissue of wounds with advanced wound age indicates a survival time of more than about 1.5 months, but a positive staining in older wounds cannot be excluded
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