The Effect of Alpha Lipoic Acid in Preventing Atherosclerosis Lesion on the Abdominal Aorta of Diabetes Mellitus Type 2 Rats

Various studies have studied the clinical use of alpha-lipoic acid (ALA) for treating diabetic complications. The protective effect of  lipoic acid in  atherosclerosis induced by diabetes mellitus type 2 (DM type 2)  still needs further study. This study was aimed to investigate the protective effect of ALA in atherosclerosis induced by DM type 2. Twenty one rats were divided into 3 groups: control, DM−treated and DM+ALA-treated group. Type-2 diabetes was induced by intraperitoneal injection of streptozotocin (50 mg/kg) followed by nicotinamide (110 mg/kg). ALA was administered orally at a dose of 60 mg/kg body weight/day throughout the feeding period for three weeks. This study was an experimental study with post-test only with control method which was conducted at Biochemistry laboratory, Faculty of Medicine Universitas Riau from June-October 2016. This study showed that DM+ALA treated group  achieved lower atherosclerosis scores than DM-treated group and the difference between the two groups was statistically significant. In conclusion, alpha lipoic acid can prevent atherosclerosis lesions induced by diabetes

Identifikasi Bakteri Batang Gram Negatif Penghasil Extended Spectrum Β Lactamase (Esbl) Dari Ulkus Diabetikum Derajat I Dan II Waigner Di Bangsal Penyakit Dalam RSUD Arifin Achmad Provinsi Riau

Diabetic ulcers are open wound on the skin surface effect of neuropathy andvascular insufficiency that made the wound are often not felt by the patient , and candevelop into an infection caused by aerobic and anaerobic bacteria . Diabetic ulcersmedical patients are very susceptible infected with antibiotic-resistant bacteria likeESBL -producing bacteria. This descriptive study to detect Gram-negative bacillibacteria producing enzyme Extended spectrum beta - lactamase ( ESBL ) in diabeticulcers, are carried out using a double disc approximation Method ( DAM ) to thenumber of study subjects were 26 people with diabetic ulcers Wagner grade I and II .The results obtained ESBL producing bacteria as much as 16 samples ( 69.57 % )some of them were Citrobacter freundi , Enterobacter sp , Proteus sp , Klebsiella sprespectively – each of them are 3 isolates ( 18.75 % ) , and Pseudomonas sp ,Salmonella sp respectively – each of them are 2 isolates ( 12.5 %) .The results of theantibiotic sensitivity test showed that Gram-negative bacilli bacteria producing ESBLhave high sensitivity toward amikacin and meropenem as much as 16 samples ( 100% ) Antibiotics Betalaktam groups such as ampicillin, and third -generationcephalosporins such as cefotaxcime , ceftriaxone, and ceftazidime factually hadexperienced resistance 100% toward ESBL producing bacteria.Keywordrs : diabetic ulcers , Double disc aproximation Method ( DAM ) , Gram -negative bacilli bacteria , Extended spectrum beta - lactamase ( ESBL

Gambaran Kualitas Hidup Pasien Gagal Ginjal Kronik yang Menjalani Terapi Continuous Ambulatory Peritoneal Dialysis di RSUD Arifin Achmad Provinsi Riau dengan Menggunakan Kuesioner KDQOL-SFTM

Chronic renal failure is an end stage of renal disease that can be treated by dialysis, which one of them is Continuous Ambulatory Peritoneal Dialysis (CAPD). CAPD is a dialysis technique uses peritoneal membrane as dialysis membrane that splits between dyalisate in peritoneal membrane with blood plasm in peritoneal vessels. CAPD as a theraphy for chronic renal failure patients can be examined by KDQOL-SFTM questionnaire to measures its effect on patients' quality of life. This research helds on purpose to get a representation of Continuous Ambulatory Peritoneal Dialysis (CAPD) patients' life quality. This is a descriptive method of research with cross sectional approachment and had implemented on February 2014. About 47 chronic renal failure patients have been undergoing CAPD therapy. Research results showed most of respondents is dominated by male respondents (59,57%). Results from respondent by age category indicated that category 18-44 years old and category 45-64 years old are relatively equal ini amount. Category by ethnic showed that most of respondents are Malay ethnic (31,91%). Respondents have been educated and got undergraduated and degree: D1/D2/D3/S1 (53,19%). Most of respondents have been married (93,61%) and work as a housewife, retired and unemployed (36,17%). CAPD has been used as theraphy for about 1-5 years by most respondents (72,34%). Most chronic renal failure patient who undergo CAPD therapy at RSUD Arifin Achmad Riau Province (76,59%) have hight value of quality of lif

Identifikasi Dan Resistensi Bakteri Methicillin Resistant Staphylococcus Aureus (Mrsa) Dari Ulkus Diabetikum Derajat I Dan II Wagner Di Bagian Penyakit Dalam RSUD Arifin Achmad

Diabetic ulcers is a chronic complications of diabetic mellitus which caused people treated in hospital about 80%. Patients with diabetic ulcers need more care and additional costs. It will be wretched if the infection caused by multidrugs resistant bacterials like Methicillin resistant Staphylococcus aureus (MRSA). This research aimed to identified and understand the resistance of MRSA bacteria from Wagner grade I and II diabetic ulcers at department of Internal Medicine of RSUD Arifin Achmad. Samples were taken with a swab technique and then the bacteria were identified and further resistance test with Kirby-bauer disk diffusion method. This research reported about 6 samples (21,42%) from 28 grade I and II swabs diabetic ulcers are Staphylococcus aureus and 5 samples 83,33% from 6 samples Staphylococcus aureus were identified as MRSA. Antibiotics trimethoprim-sulfamethoxazole, chloramphenicol and gentamycin resistance test results had sensitivity 100% to MRSA bacteria. Followed by ofloxacin 60% and ciprofloxacin 40%

Breakhthrough Infection Pasca Pemberian Booster mRNA Heterolog pada Tenaga Kesehatan di RSUD Arifin Achmad

Tujuan: Mengetahui prevalensi dan karakteristik responden breakthrough infection pada tenaga kesehatan di RSUD Arifin Achmad Provinsi Riau dalam 14 hari – 6 bulan pasca vaksinasi booster mRNA-1273. Metode: Metode penelitian cross sectional yang dilakukan pada Juli – September 2022 menggunakan sampel sebanyak 123 responden melalui wawancara. Hasil: 14 responden (11,4%) mengalami breakthrough infection. Mayoritas responden breakthrough infection berjenis kelamin perempuan (78,6%), rata-rata usia 44,1 tahun, pekerjaan dokter (42,9%), IMT obesitas (57,1%), mayoritas tidak ada komorbid (85,7%) dan bukan penyintas (85,7%). Simpulan: Terdapat kejadian breakthrough infection pada tenaga kesehatan di RSUD Arifin Ahmad pada 14 hari – 6 bulan pasca pemberian booster mRNA Heterolog (mRNA-1273).Kata kunci: breakthrough infection; vaksin booster; mRNA-1273; vaksin heterolog; COVID-1

Identification of Amino Acids Essential for Viral Replication in the HCMV Helicase-Primase Complex

Promising new inhibitors that target the viral helicase-primase complex have been reported to block replication of herpes simplex and varicella-zoster viruses, but they have no activity against human cytomegalovirus (HCMV), another herpesvirus. The HCMV helicase-primase complex (pUL105-pUL102-pUL70) is essential for viral DNA replication and could thus be a relevant antiviral target. The roles of the individual subunits composing this complex remain to be defined. By using sequence alignment of herpesviruses homologs, we identified conserved amino acids in the putative pUL105 ATP binding site and in the putative pUL70 zinc finger pattern. Mutational analysis of several of these amino acids both in pUL105 and pUL70, proved that they are crucial for viral replication. We also constructed, by homology modeling, a theoretical structure of the pUL105 N-terminal domain which indicates that the mutated conserved amino acids in this domain could be involved in ATP hydrolysis

Peningkatan peran serta masyarakat dalam upaya pencegahan dan pengobatan tuberkulosis di Sentajo Raya, Kabupaten Kuantan Singingi

The purpose of community service was to increase community participation in the prevention and treatment of tuberculosis (TB) through training of health cadres and the establishment of village TB posts in the working area of Sentajo Raya health centre. The activity method in the form of TB cadre training, the establishment of a Village TB Post and monitoring evaluation. The results of this activity were 30 people who had received training and were appointed as TB cadres. All TB cadres get TB module books, cadre pocketbooks and certificates. TB cadres must be able to play a role in the prevention and treatment of TB in their respective villages. The establishment of the first village TB post in the working area of Sentajo Raya Health Center was Pulau Kopung Sentajo Village. In the monitoring and evaluation activities of Pulau Kopung village Sentajo, a village TB post was formed in the "Village Population Activity Corner". Discussions with cadres and village heads were conducted to find out the problems faced, and there were activity books for cadres, PMO cards, and Banner TB for village TB posts. This activity can be carried out well and has the full support of the government and the community. They hope that this current activity and collaboration can be continued.Pengabdian kepada masyarakat ini bertujuan melakukan peningkatan peran serta masyarakat dalam pencegahan dan pengobatan tuberkulosis (TB) melalui pelatihan kader kesehatan dan pembentukan pos TB desa di wilayah kerja puskesmas Sentajo Raya. Metode kegiatan ini berupa kegiatan pelatihan kader, pembentukan Pos TB Desa dan monitoring evaluasi. Hasil kegiatan ini adalah kader kesehatan yang sudah mendapat pelatihan dan dilantik sebagai kader TB sebanyak 30 orang. Semua kader TB mendapatkan buku modul TB, buku saku kader dan sertfikat. Kader TB harus mampu berperan dalam pencegahan dan pengobatan TB di desanya masing-masing. Pembentukan pos TB desa pertama di wilayah kerja Puskesmas Sentajo Raya adalah Desa Pulau Kopung Sentajo. Pada monev di desa Pulau Kopung Sentajo telah terbentuk pos TB desa di “Pojok Kegiatan Kependudukan Desa”. Monev dilaksanakan berupa diskusi dengan kader dan kepala desa mengenai kegiatan yang sudah dilaksanakan dan masalah yang dihadapi oleh kader. Pada monev diberikan buku kegiatan kader, kartu PMO dan Bannner TB untuk pos TB desa. Kegiatan ini dapat terlaksana dengan baik dan mendapat dukungan penuh dari pemerintah dan masyarakat. Mereka berharap kegiatan dan kerjasama yang sudah terjalin ini dapat dilanjutkan