Anesthetic experiences of myxoma removal surgery in two patients with Carney complex -A report of two cases-

Carney complex is an autosomal dominant disorder that occurs due to a mutation in PRKAR1A, which encodes protein kinase A. The clinical features are multiple endocrine gland neoplasms, skin tumors, pigmented skin lesions, myxomas, and schwannomas. In Carney complex, the cardiac myxoma is a common co-morbidity. It occurs in multiples, during young age, regardless of gender and cardiac chamber and is known to recur frequently. Therefore there are high risks of adhesion and massive bleeding due to repeated surgeries. Such surgical risks account for over 50% of disease-specific mortality of Carney complex patients. Here, we present anesthetic experiences of myxoma removal surgery in two patients with Carney complex

Cardiac monitoring in HER2-positive patients on trastuzumab treatment

Trastuzumab prolongs progression-free and overall survival in patients with human epidermal growth factor receptor 2 (HER2) positive breast cancer. However, trastuzumab treatment is hampered by cardiotoxicity, defined as a left ventricular ejection fraction (LVEF) decline with a reported incidence ranging from 3 to 27% depending on variable factors. Early identification of patients at increased risk of trastuzumab-induced myocardial damage is of great importance to prevent deterioration to irreversible cardiotoxicity. Although current cardiac monitoring with multi gated acquisition (MUGA) scanning and/or conventional 2D-echocardiography (2DE) have a high availability, their reproducibility are modest, and more sensitive and reliable techniques are needed such as 3D-echocardiography (3DE) and speckle tracking echocardiography (STE). But which other diagnostic imaging modalities are available for patients before and during trastuzumab treatment? In addition, what is the optimal frequency and duration of cardiac monitoring? At last, which biomarker monitoring strategies are currently available for the identification of cardiotoxicity in patients treated with trastuzumab

ONCOR: design of the Dutch cardio-oncology registry

Background: The relative new subspecialty ‘cardio-oncology’ was established to meet the growing demand for an interdisciplinary approach to the management of cancer therapy–related cardiovascular adverse events. In recent years, specialised cardio-oncology services have been implemented worldwide, which all strive to improve the cardiovascular health of cancer patients. However, limited data are currently available on the outcomes and experiences of these specialised services, and optimal strategies for cardio-oncological care have not been established. / Aim: The ONCOR registry has been created for prospective data collection and evaluation of cardio-oncological care in daily practice. / Methods: Dutch hospitals using a standardised cardio-oncology care pathway are included in this national, multicentre, observational cohort study. All patients visiting these cardio-oncology services are eligible for study inclusion. Data collection at baseline consists of the (planned) cancer treatment and the cardiovascular risk profile, which are used to estimate the cardiotoxic risk. Information regarding invasive and noninvasive tests is collected during the time patients receive cardio-oncological care. Outcome data consist of the incidence of cardiovascular complications and major adverse cardiac events, and the impact of these events on the oncological treatment. / Discussion: Outcomes of the ONCOR registry may aid in gaining more insight into the incidence of cancer therapy–related cardiovascular complications. The registry facilitates research on mechanisms of cardiovascular complications and on diagnostic, prognostic and therapeutic strategies. In addition, it provides a platform for future (interventional) studies. Centres with cardio-oncology services that are interested in contributing to the ONCOR registry are hereby invited to participate

De zin van het laatste avondmaal volgens de Nieuw-Testamentische teksten: beeld of werkelijkheid

Contains fulltext : mmubn000001_067798543.pdf (publisher's version ) (Open Access)Promotor : W. GrossouwXII, 215 p

Food and the City of Tomorrow

ExplorelabArchitectureArchitecture and The Built Environmen

Data Augmentation in a Hybrid Approach for Aspect-Based Sentiment Analysis

Data augmentation is a way to increase the diversity of available data by applying constrained transformations on the original data. This strategy has been widely used in image classification but has to the best of our knowledge not yet been used in aspect-based sentiment analysis (ABSA). ABSA is a text analysis technique that determines aspects and their associated sentiment in opinionated text. In this paper, we investigate the effect of data augmentation on a state-of-the-art hybrid approach for aspect-based sentiment analysis (HAABSA). We apply modified versions of easy data augmentation (EDA), backtranslation, and word mixup. We evaluate the proposed techniques on the SemEval 2015 and SemEval 2016 datasets. The best result is obtained with the adjusted version of EDA, which yields a 0.5 percentage point improvement on the SemEval 2016 dataset and 1 percentage point increase on the SemEval 2015 dataset compared to the original HAABSA model.Comment: The 36th ACM/SIGAPP Symposium On Applied Computing, Virtual Conference, March 22-March 26, 20