Geographical Detector-Based Risk Assessment of the Under-Five Mortality in the 2008 Wenchuan Earthquake, China

On 12 May, 2008, a devastating earthquake registering 8.0 on the Richter scale occurred in Sichuan Province, China, taking tens of thousands of lives and destroying the homes of millions of people. Many of the deceased were children, particular children less than five years old who were more vulnerable to such a huge disaster than the adult. In order to obtain information specifically relevant to further researches and future preventive measures, potential risk factors associated with earthquake-related child mortality need to be identified. We used four geographical detectors (risk detector, factor detector, ecological detector, and interaction detector) based on spatial variation analysis of some potential factors to assess their effects on the under-five mortality. It was found that three factors are responsible for child mortality: earthquake intensity, collapsed house, and slope. The study, despite some limitations, has important implications for both researchers and policy makers

Potential Role of Decoy B7-H4 in the Pathogenesis of Rheumatoid Arthritis: A Mouse Model Informed by Clinical Data

Finding an association between soluble B7-H4 and rheumatoid arthritis severity, Lieping Chen and colleagues use a mouse model to show that the soluble form blocks the inhibitory function of cell-surface B7-H4

Design procedures of reinforced concrete framed buildings in Nepal and its impact on seismic safety

The present paper analyses the design procedure and its impact on seismic safety of the structures. For this, a representative reinforced concrete frame building (WDS) is designed and the results are compared with similar buildings detailed with: i) Current Construction Practices (CCP); ii) the Nepal Building Code (NBC) and iii) the Modified Nepal Building Code (NBC+) recommendations. The seismic performance evaluation is done with global strength, inter-storey drift and displacement of the structures. Likewise, the sensitivity of the structural and geometrical parameters of the RC frame building is studied through nonlinear analysis. The study parameters considered for parametric analysis are column size, beam size, inter-storey height, bay length, bay width, and compressive strength of concrete. The results show that the influence on the structural behaviour, particularly by variation in column size and inter-storey height. Additionally, the influence of the seismic zone factor on reinforcement demand of the structure is studied. The result shows that structures designed for high to medium seismic hazard demands double the reinforcement in beams compared to structures in low seismic zone

Tissue-Expressed B7-H1 Critically Controls Intestinal Inflammation

B7-H1 (PD-L1) on immune cells plays an important role in T cell coinhibition by binding its receptor PD-1. Here, we show that both human and mouse intestinal epithelium express B7-H1 and that B7-H1-deficient mice are highly susceptible to dextran sodium sulfate (DSS)- or trinitrobenzenesulfonic acid (TNBS)-induced gut injury. B7-H1 deficiency during intestinal inflammation leads to high mortality and morbidity, which are associated with severe pathological manifestations in the colon, including loss of epithelial integrity and overgrowth of commensal bacteria. Results from bone marrow chimeric and knockout mice show that B7-H1 expressed on intestinal parenchyma, but not on hematopoietic cells, controls intestinal inflammation in an adaptive immunity-independent fashion. Finally, we demonstrate that B7-H1 dampened intestinal inflammation by inhibiting tumor necrosis factor α (TNF-α) production and by stimulating interleukin 22 secretion from CD11c+CD11b+ lamina propria cells. Thus, our data uncover a mechanism through which intestinal tissue-expressed B7-H1 functions as an essential ligand for innate immune cells to prevent gut inflammation