1 research outputs found
Polystyrene-Supported TRIP: A Highly Recyclable Catalyst for Batch and Flow Enantioselective Allylation of Aldehydes
The
widely applicable TRIP phosphoric acid catalyst has been immobilized
on polystyrene using a copolymerization-based strategy. The resin
(<b>PS-TRIP</b>) has proven to be highly active and enantioselective
in the asymmetric allylboration of aldehydes. Moreover, it has shown
to be extremely robust, as it can be reused for 18 times, after which
it still retained its activity. Lastly, to further prove the benefits
of the immobilization, a continuous flow experiment spanning 28 h
has been carried out with very high yields and ee’s