Expected performance of a Laue lens based on bent crystals

In the context of the LAUE project devoted to build a long focal length focusing optics for soft gamma-ray astronomy (70/100 keV to $>$600 keV), we present results of simulation of a Laue lens, based on bent crystals in different assembling configurations (quasi-mosaic and reflection-like geometries). The main aim is to significantly overcome the sensitivity limits of the current generation of gamma-ray telescopes and improve the imaging capability.Comment: 7 pages, 7 figures, presented at the Space Telescopes and Instrumentation Symposium 2012: Ultraviolet to Gamma Ray Conference. Published in Proceedings of the SPIE, Volume 8443, id. 844331-844331-7 (2012

Bent crystal selection and assembling for the LAUE project

For the first time, with the Laue project, bent crystals are being used for focusing photons in the 80-300 keV energy range. The advantage is their high reflectivity and better Point Spread Function with respect to the mosaic flat crystals. Simulations have already shown their excellent focusing capability which makes them the best candidates for a Laue lens whose sensitivity is also driven by the size of the focused spot. Selected crystals are Germanium (perfect, (111)) and Gallium Arsenide (mosaic, (220)) with 40 m curvature radius to get a spherical lens with 20 m long focal length. A lens petal is being built. We report the measurement technique by which we are able to estimate the exact curvature of each tile within a few percent of uncertainty and their diffraction efficiency. We also discuss some results.Comment: 9 pages, 15 figures, SPIE conference vol. 8861 (2013

Results of the simulations of the petal/lens as part of the LAUE project

In the context of the LAUE project for focusing hard X-/gamma rays, a petal of the complete lens is being assembled at the LARIX facility in the Department of Physics and Earth Science of the University of Ferrara. The lens petal structure is composed of bent Germanium and Gallium Arsenide crystals in transmission geometry. We present the expectations derived from a mathematical model of the lens petal. The extension of the model for the complete LAUE project in the 90 -- 600 keV energy range will be discussed as well. A quantitative analysis of the results of these simulations is also presented.Comment: 12 pages, 26 figures, SPIE optics + Photonics conference 2013, Vol: 886

Cosmological constraints from low redshift 21 cm intensity mapping with machine learning

The future 21 cm intensity mapping observations constitute a promising way to trace the matter distribution of the Universe and probe cosmology. Here we assess its capability for cosmological constraints using as a case study the BINGO radio telescope, that will survey the Universe at low redshifts ($0.13 < z < 0.45$). We use neural networks (NNs) to map summary statistics, namely, the angular power spectrum (APS) and the Minkowski functionals (MFs), calculated from simulations into cosmological parameters. Our simulations span a wide grid of cosmologies, sampled under the $\Lambda$CDM scenario, {$\Omega_c, h$}, and under an extension assuming the Chevallier-Polarski-Linder (CPL) parameterization, {$\Omega_c, h, w_0, w_a$}. In general, NNs trained over APS outperform those using MFs, while their combination provides 27% (5%) tighter error ellipse in the $\Omega_c-h$ plane under the $\Lambda$CDM scenario (CPL parameterization) compared to the individual use of the APS. Their combination allows predicting $\Omega_c$ and $h$ with 4.9% and 1.6% fractional errors, respectively, which increases to 6.4% and 3.7% under CPL parameterization. Although we find large bias on $w_a$ estimates, we still predict $w_0$ with 24.3% error. We also confirm our results to be robust to foreground contamination, besides finding the instrumental noise to cause the greater impact on the predictions. Still, our results illustrate the capability of future low redshift 21 cm observations in providing competitive cosmological constraints using NNs, showing the ease of combining different summary statistics.Comment: 17 pages, 13 figure

The role of autophagy in resistance to targeted therapies

Autophagy is a self-degradative cellular process, involved in stress response such as starvation, hypoxia, and oxidative stress. This mechanism balances macro-molecule recycling to regulate cell homeostasis. In cancer, autophagy play a role in the development and progression, while several studies describe it as one of the key processes in drug resistance. In the last years, in addition to standard anti-cancer treatments such as chemotherapies and irradiation, targeted therapy became one of the most adopted strategies in clinical practices, mainly due to high specificity and reduced side effects. However, similar to standard treatments, drug resistance is the main challenge in most patients. Here, we summarize recent studies that investigated the role of autophagy in drug resistance after targeted therapy in different types of cancers. We highlight positive results and limitations of pre-clinical and clinical studies in which autophagy inhibitors are used in combination with targeted therapies. Refereed/Peer-reviewe

Pentose phosphate pathway inhibition induce Endoplasmic Reticulum stress and autophagy

Pentose phosphate pathway (PPP) is a major glucose catabolism pathway that supplies the cell with a reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) and ribose-5-phosphate. NADPH is necessary for the detoxification of reactive oxygen species (ROS) and reductive biosynthesis. A key player in this pathway is the enzyme glucose-6-phosphate dehydrogenase (G6PD) that reduces NADP+ to NADPH, oxidizes glucose-6-phosphate and prevents ROS accumulation. Here, we show that the natural molecule 3,4’,5-trihydroxystilbene-3-β-d-glucoside (Polydatin) inhibits glucose-6-phosphate dehydrogenase (G6PD). As expected, G6PD inhibition causes an imbalance in NADP+/NADPH ratio, leading to a redox imbalance, followed by Endoplasmic Reticulum (ER) stress, autophagy, cell cycle block and apoptosis. we have demonstrated a link between G6PD inhibition and ER stress, showing that Unfolded Protein Response mediator such as PERK and IRE-1 have a key role in inducing autophagy and apoptosis after PPP block. Moreover, combination of PPP inhibition with autophagy inhibitors, such as chloroquine, strongly potentiate cytotoxicity on cancer cells, evidencing the role of autophagy as an escaping mechanism. This results shows that double inhibition of PPP and autophagy may be an affective therapeutic strategy against cancer

Testing synchrotron models and frequency resolution in BINGO 21 cm simulated maps using GNILC

To recover the 21 cm hydrogen line, it is essential to separate the cosmological signal from the much stronger foreground contributions at radio frequencies. The BINGO radio telescope is designed to measure the 21 cm line and detect BAOs using the intensity mapping technique. This work analyses the performance of the GNILC method, combined with a power spectrum debiasing procedure. The method was applied to a simulated BINGO mission, building upon previous work from the collaboration. It compares two different synchrotron emission models and different instrumental configurations, in addition to the combination with ancillary data to optimize both the foreground removal and recovery of the 21 cm signal across the full BINGO frequency band, as well as to determine an optimal number of frequency bands for the signal recovery. We have produced foreground emissions maps using the Planck Sky Model, the cosmological Hi emission maps are generated using the FLASK package and thermal noise maps are created according to the instrumental setup. We apply the GNILC method to the simulated sky maps to separate the Hi plus thermal noise contribution and, through a debiasing procedure, recover an estimate of the noiseless 21 cm power spectrum. We found a near optimal reconstruction of the Hi signal using a 80 bins configuration, which resulted in a power spectrum reconstruction average error over all frequencies of 3%. Furthermore, our tests showed that GNILC is robust against different synchrotron emission models. Finally, adding an extra channel with CBASS foregrounds information, we reduced the estimation error of the 21 cm signal. The optimisation of our previous work, producing a configuration with an optimal number of channels for binning the data, impacts greatly the decisions regarding BINGO hardware configuration before commissioning.Comment: Submitted to A&

The BINGO Project IX: Search for Fast Radio Bursts -- A Forecast for the BINGO Interferometry System

The Baryon Acoustic Oscillations (BAO) from Integrated Neutral Gas Observations (BINGO) radio telescope will use the neutral Hydrogen emission line to map the Universe in the redshift range $0.127 \le z \le 0.449$, with the main goal of probing BAO. In addition, the instrument optical design and hardware configuration support the search for Fast Radio Bursts (FRBs). In this work, we propose the use of a BINGO Interferometry System (BIS) including new auxiliary, smaller, radio telescopes (hereafter \emph{outriggers}). The interferometric approach makes it possible to pinpoint the FRB sources in the sky. We present here the results of several BIS configurations combining BINGO horns with and without mirrors ($4$ m, $5$ m, and $6$ m) and 5, 7, 9, or 10 for single horns. We developed a new {\tt Python} package, the {\tt FRBlip}, which generates synthetic FRB mock catalogs and computes, based on a telescope model, the observed signal-to-noise ratio (S/N) that we used to compute numerically the detection rates of the telescopes and how many interferometry pairs of telescopes (\emph{baselines}) can observe an FRB. FRBs observed by more than one baseline are the ones whose location can be determined. We thus evaluate the performance of BIS regarding FRB localization. We found that BIS will be able to localize 23 FRBs yearly with single horn outriggers in the best configuration (using 10 outriggers of 6 m mirrors), with redshift $z \leq 0.96$; the full localization capability depends on the number and the type of the outriggers. Wider beams are best to pinpoint FRB sources because potential candidates will be observed by more baselines, while narrow beams look deep in redshift. The BIS can be a powerful extension of the regular BINGO telescope, dedicated to observe hundreds of FRBs during Phase 1. Many of them will be well localized with a single horn + 6 m dish as outriggers.(Abridged)Comment: 12 pages, 9 figures, 5 tables, submitted to A&