Sex/Gender- and Age-Related Differences in β-Adrenergic Receptor Signaling in Cardiovascular Diseases

Sex differences in cardiovascular disease (CVD) are often recognized from experimental and clinical studies examining the prevalence, manifestations, and response to therapies. Compared to age-matched men, women tend to have reduced CV risk and a better prognosis in the premenopausal period. However, with menopause, this risk increases exponentially, surpassing that of men. Although several mechanisms have been provided, including sex hormones, an emerging role in these sex differences has been suggested for β-adrenergic receptor (β-AR) signaling. Importantly, β-ARs are the most important G protein-coupled receptors (GPCRs), expressed in almost all the cell types of the CV system, and involved in physiological and pathophysiological processes. Consistent with their role, for decades, βARs have been considered the first targets for rational drug design to fight CVDs. Of note, β-ARs are seemingly associated with different CV outcomes in females compared with males. In addition, even if there is a critical inverse correlation between β-AR responsiveness and aging, it has been reported that gender is crucially involved in this age-related effect. This review will discuss how β-ARs impact the CV risk and response to anti-CVD therapies, also concerning sex and age. Further, we will explore how estrogens impact β-AR signaling in women

Do Higher Cigarette Prices Encourage Youth to Use Marijuana?

Every major national tobacco legislation proposed in the past two years has called for significant increases in the price of cigarettes as a way to discourage youths from smoking. One argument used to oppose these bills is that increases in the price of cigarettes would cause youths to substitute marijuana for cigarettes. Although it has long been believed that cigarettes are a gateway drug,' no economic research has been done to determine whether cigarettes and marijuana are economic complements or substitutes. This paper begins to fill the void in the current research by examining the contemporaneous relationship between the demands for cigarettes and marijuana among a nationally representative sample of 8th, 10th and 12th graders from the 1992-1994 Monitoring the Future Project. Two part models are used to estimate reduced form demand equations. Examination of the cross-price effects clearly shows that higher cigarette prices will not increase marijuana use among youths. In addition to reducing youth smoking, we find that higher cigarette prices significantly reduce the average level of marijuana used by current users. Cigarette prices also have a negative effect on the probability of using marijuana findings are not significant at conventional levels.

Importance of spinal deformity index in risk evaluation of VCF (vertebral compression fractures) in obese subjects: prospective study.

Introduction Obesity and osteoporosis share many features and recent studies have identified many similarities suggesting common pathophysiological mechanisms. Obesity is associated with a higher risk of non-traumatic fractures despite bone mineral density (BMD) being normal or even increased. Materials and methods 54 obese subjects were analyzed (51 ± 16 years, 10 males, 44 females). Spinal deformity index (SDI) is a semi-quantitative method that may be a surrogate index of bone microarchitecture. SDI index was higher in patients than in controls. In 87.5 % of patients and 10 % of controls we found morphometric vertebral fractures, despite a DEXA Tscore not diagnostic of osteoporosis. Conclusion The objective of this study was to assess in obese patients levels of 25OH vitamin D, parathyroid hormone, serum and urinary calcium (Ca) and phosphorus (P), BMD, and SDI. 87.5 % of the obese subjects present nontraumatic vertebral fractures and reduced bone quality as measured by SDI

Predictors of short-term readmission after beyond total mesorectal excision for primary locally advanced and recurrent rectal cancer

Unplanned readmissions heavily affect the cost of health care and are used as an indicator of performance. No clear data are available regarding beyond-total mesorectal excision (bTME) procedure. Aim of the study is to identify patient-related and surgery-related factors influencing the 30-day readmissions after bTME. Retrospective data were collected from 220 patients who underwent bTME procedures at single centre between 2006 and 2016. Patient-related and operative factors were assessed, including body mass index (BMI), age, gender, American Society of Anaesthesiologists’ (ASA) score, preoperative stage, neo-adjuvant therapy, primary tumour vs recurrence, the extent of surgery. The readmission rate was 8.18%. No statistically significant association was found with BMI, ASA score, length of stay and stay in the intensive care unit, primary vs recurrent tumour or blood transfusions. Not quite statistically significant was the association with pelvic side wall dissection (OR 3.32, p = 0.054). Statistically significant factors included preoperative stage > IIIb (OR: 4.77, p = 0.002), neo-adjuvant therapy (OR: 0.13, p = 0.0006), age over 65 years (OR: 5.96, p = 0.0005), any re-intervention during the first admission (OR: 7.4, p = 0.0001), and any post-operative complication (OR: 9.01, p = 0.004). The readmission rate after beyond-TME procedure is influenced by patient-related factors as well as post-operative morbidity

Coulomb-gas formulation of SU(2) branes and chiral blocks

We construct boundary states in $SU(2)_k$ WZNW models using the bosonized Wakimoto free-field representation and study their properties. We introduce a Fock space representation of Ishibashi states which are coherent states of bosons with zero-mode momenta (boundary Coulomb-gas charges) summed over certain lattices according to Fock space resolution of $SU(2)_k$. The Virasoro invariance of the coherent states leads to families of boundary states including the B-type D-branes found by Maldacena, Moore and Seiberg, as well as the A-type corresponding to trivial current gluing conditions. We then use the Coulomb-gas technique to compute exact correlation functions of WZNW primary fields on the disk topology with A- and B-type Cardy states on the boundary. We check that the obtained chiral blocks for A-branes are solutions of the Knizhnik-Zamolodchikov equations.Comment: 14 pages, 3 figures, revtex4. Essentially the published versio

Wrapped Magnetized Branes: Two Alternative Descriptions?

We discuss two inequivalent ways for describing magnetized D-branes wrapped N times on a torus T^2. The first one is based on a non-abelian gauge bundle U(N), while the second one is obtained by means of a Narain T-duality transformation acting on a theory with non-magnetized branes. We construct in both descriptions the boundary state and the open string vertices and show that they give rise to different string amplitudes. In particular, the description based on the gauge bundle has open string vertex operators with momentum dependent Chan-Paton factors.Comment: 60 pages, LaTe

N=1 gauge superpotentials from supergravity

We review the supergravity derivation of some non-perturbatively generated effective superpotentials for N=1 gauge theories. Specifically, we derive the Veneziano-Yankielowicz superpotential for pure N=1 Super Yang-Mills theory from the warped deformed conifold solution, and the Affleck-Dine-Seiberg superpotential for N=1 SQCD from a solution describing fractional D3-branes on a C^3 / Z_2 x Z_2 orbifold.Comment: LaTeX, iopart class, 8 pages, 3 figures. Contribution to the proceedings of the workshop of the RTN Network "The quantum structure of space-time and the geometric nature of fundamental interactions", Copenhagen, September 2003; v2: published version with minor clarification

Longitudinal phase space measurement at the ELI-NP Compton gamma source

Virtual bunch length measurement can be carried out by means of ELEGANT code for tracking the bunch particles from RF deflector to the screen. The technique relies on the correlation between the bunch longitudinal coordinate and transverse coordinates induced through a RF deflector. Therefore, the bunch length measurement can be carried out measuring the vertical spot size at the screen, placed after the RF deflector. The deflecting voltage amplitude affects the resolution. Adding a dispersive element, e.g. a magnetic dipole between RF deflector and the screen, the full longitudinal phase space can be measured. In this paper, we discuss some issues relevant for the electron linac of the Compton source at the Extreme Light Infrastructure - Nuclear Physics (ELI-NP)