2 research outputs found

    Technological failures caused by cephalexin©in set-type sheep's milk yogurt

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    Given their broad spectrum, cephalosporins are used for combating mastitis in dairy species. Many cephalosporins, such as cephalexin, have not been authorized for use in lactating sheep and because veterinary drugs for use in small species are lacking, the regulations of several countries allow extra-label use. Incorrect use of extra-label tools may cause residues in milk, and could negatively affect public health by provoking technological failures in the dairy fermenting processes. The effects of cephalexin, at concentrations close to its European Maximal Residue Limit (MRL), have been studied in set-type yogurts made from sheep s milk. Milk was fortified at different cephalexin concentrations and stored yogurts were evaluated in acidification, textural parameters and microbial evolution terms. The results showed that cephalexin concentrations equal to or below its MRL could mainly inhibit normal Streptococcus thermophilus growth and provoke some alterations to acidity parameters, which were more marked in the L(+)-lactic acid isomer.This work has been funded by Project PCI-03-006 (JJCC Castilla-La Mancha, Spain).Noves, B.; Libran, C.; Licon, CC.; Molina Pons, MP.; Molina Casanova, A.; Berruga Fernandez, MI. (2015). Technological failures caused by cephalexin©in set-type sheep's milk yogurt. CyTA - Journal of Food. 13(3):408-414. https://doi.org/10.1080/19476337.2014.990519S408414133AMBROS, L., KREIL, V., TARRAGONA, L., MONFRINOTTI, A., HALLU, R., & REBUELTO, M. (2010). Comparative pharmacokinetics of intravenous cephalexin in pregnant, lactating, and nonpregnant, nonlactating goats. Journal of Veterinary Pharmacology and Therapeutics, 34(4), 397-402. doi:10.1111/j.1365-2885.2010.01232.xBeltrĂĄn, M. C., Althaus, R. L., Berruga, M. I., Molina, A., & Molina, M. P. (2014). Detection of antibiotics in sheep milk by receptor-binding assays. International Dairy Journal, 34(2), 184-189. doi:10.1016/j.idairyj.2013.09.006BERRUGA, M. I., NOVÉS, B., MOLINA, M. P., ROMÁN, M., & MOLINA, A. (2008). Influence of cephalosporins on the coagulation time of yogurt made from ewes’ milk. International Journal of Dairy Technology, 61(4), 372-378. doi:10.1111/j.1471-0307.2008.00421.xBonczar, G. (2002). The effects of certain factors on the properties of yoghurt made from ewe’s milk. Food Chemistry, 79(1), 85-91. doi:10.1016/s0308-8146(02)00182-6Dewdney, J. M., Maes, L., Raynaud, J. P., Blanc, F., Scheid, J. P., Jackson, T., 
 Verschueren, C. (1991). Risk assessment of antibiotic residues of ÎČ-lactams and macrolides in food products with regard to their immuno-allergic potential. Food and Chemical Toxicology, 29(7), 477-483. doi:10.1016/0278-6915(91)90095-oGrunwald, L. (2002).Untersuchungen zur Analytik und zum Einfluss technologischer Prozesse auf PenicillinrĂŒchstĂ€nde in Milch[Investigation and analysis on the influence of penicillin residues in milk on technological processes] (Doctoral Thesis). UniversitĂ€t Gesamthochschule Wuppertal, Wuppertal, Germany.HIRANO, R., HIRANO, M., OOOKA, M., DOSAKO, S., NAKAJIMA, I., & IGOSHI, K. (1998). Lactoperoxidase Effects on Rheological Properties of Yogurt. Journal of Food Science, 63(1), 35-38. doi:10.1111/j.1365-2621.1998.tb15670.xJarvis, B. (1973). Comparison of an Improved Rose Bengal-Chlortetracycline Agar with Other Media for the Selective Isolation and Enumeration of Moulds and Yeasts in Foods. Journal of Applied Bacteriology, 36(4), 723-727. doi:10.1111/j.1365-2672.1973.tb04157.xKatsiari, M. C., Voutsinas, L. P., & Kondyli, E. (2002). Manufacture of yoghurt from stored frozen sheep’s milk. Food Chemistry, 77(4), 413-420. doi:10.1016/s0308-8146(01)00367-3Mathur, S., & Singh, R. (2005). Antibiotic resistance in food lactic acid bacteria—a review. International Journal of Food Microbiology, 105(3), 281-295. doi:10.1016/j.ijfoodmicro.2005.03.008Molina, A., Molina, M. ., Althaus, R. ., & Gallego, L. (2003). Residue Persistence in Sheep Milk Following Antibiotic Therapy. The Veterinary Journal, 165(1), 84-89. doi:10.1016/s1090-0233(02)00173-9Oliver, S. P., Murinda, S. E., & Jayarao, B. M. (2011). Impact of Antibiotic Use in Adult Dairy Cows on Antimicrobial Resistance of Veterinary and Human Pathogens: A Comprehensive Review. Foodborne Pathogens and Disease, 8(3), 337-355. doi:10.1089/fpd.2010.0730Robinson, R. K., & Itsaranuwat, P. (s. f.). Properties of Yoghurt and their Appraisal. Fermented Milks, 76-94. doi:10.1002/9780470995501.ch4Salvador, A., & Fiszman, S. M. (2004). Textural and Sensory Characteristics of Whole and Skimmed Flavored Set-Type Yogurt During Long Storage. Journal of Dairy Science, 87(12), 4033-4041. doi:10.3168/jds.s0022-0302(04)73544-4Schmidt, C. W. (2012). FDA Proposes to Ban Cephalosporins from Livestock Feed. Environmental Health Perspectives, 120(3). doi:10.1289/ehp.120-a106Stelios, K., & Emmanuel, A. (2004). Characteristics of set type yoghurt made from caprine or ovine milk and mixtures of the two. International Journal of Food Science and Technology, 39(3), 319-324. doi:10.1111/j.1365-2621.2004.00788.xTamime, A. Y., & Robinson, R. K. (2007). Tamime and Robinson’s Yoghurt. doi:10.1533/9781845692612Voutsinas, L. P., Katsiari, M. C., Pappas, C. P., & Mallatou, H. (1996). Production of yoghurt from sheep’s milk which had been concentrated by reverse osmosis and stored frozen. 2. Compositional, microbiological, sensory and physical characteristics of yoghurt. Food Research International, 29(3-4), 411-416. doi:10.1016/0963-9969(96)83273-xVuković, V., & Kasalica, A. (2004). Effect of penicillin in concentration below the sensitivity level of biological methods on yoghurt cultures and yoghurt. Acta Alimentaria, 33(2), 167-174. doi:10.1556/aalim.33.2004.2.

    Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention

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