Genes differentially expressed in DHA plus IL-1β- versus IL-1β-treated cells.

<p>F.C. = fold change; U.F. = Genes of unknown function.</p><p>Genes regulated agonistically with IL-1.</p><p>Genes differentially expressed in DHA plus IL-1β- versus IL-1β-treated cells.</p

Validation of gene expression changes in DHA-treated HUVECs by Western blotting.

<p>(A) HUVECs were treated with DHA for 48 h, after which time total protein were extracted and subjected to Western analysis using an anti-CD47 and an anti-CYP4F2 antibody. As control for equal loading, blots were stripped and re-probed with an anti-β-actin antibody. CD47 and CYP4F2 representative immunoblots are shown in the lower panels, while densitometric analysis for the CD47 and CYPFF2, normalized to β-actin and expressed as fold induction over basal control, are shown in the upper panel. Bars represent mean±SD (n = 3). *P<0.05 vs basal control. (B) HUVECs were treated with/without DHA for 48 h, and then stimulated with IL-1β. After 24 h, total protein were extracted and subjected to Western analysis using antibodies against PDE5α, TGF-β2 and CARD11. As control for equal loading, blots were stripped and re-probed with an anti-β-actin antibody. Representative immunoblots are shown in the lower panels, while densitometric analysis for each protein, normalized to β-actin and expressed as fold over basal control, are shown in the upper panel. Bars represent mean±SD (n = 3). *P<0.05 vs IL-1β.</p

Top ten signaling and metabolic pathways regulated by docosahexaenoic acid (DHA) in resting, unactivated conditions.

<p>For the functional categorization of genes the Fisher’s exact test was used to calculate a P value (shown as bars), indicating the probability that each biological function assigned to the network is due to chance alone. The ratio represents the number of differentially expressed genes in a given pathway divided by total number of genes making up that canonical pathway.</p

Genes differentially expressed in DHA plus IL-1β versus IL-1β-treated cells.

<p>F.C. = fold change; U.F. = Genes of unknown function.</p><p>Genes regulated antagonistically with IL-1β.</p><p>Genes differentially expressed in DHA plus IL-1β versus IL-1β-treated cells.</p

Experimental design and primary conclusions of the study.

<p>Abbreviations: EC, endothelial cells; DHA, docosahexaenoic acid; IL-1, interleukin-1 β.</p

Relationship between IDEA scores and Emotional Eating in Eating Disorders patients (n: 250): moderating effect of <i>FTO</i> genotypes.

<p><b>Statistics:</b> Tables report General Linear Models <i>FTO</i> by IDEA interaction. The first models tested the effects of IDEA scores on Emotional Eating, entering age, and BMI. In the second step <i>FTO</i> genotype interaction was added. Tables showed the increasing effect of different FTO genotypes (<i>AA</i>, <i>AT</i>, <i>TT</i>).</p

General, Psychopathological and Clinical Characteristics of the Eating Disorders groups.

<p>General, Psychopathological and Clinical Characteristics of the Eating Disorders groups.</p

Comparison of clinical variables according to FTO genotypes.

<p>Comparison of clinical variables according to FTO genotypes.</p

Associations between the Antioxidant Network and Emotional Intelligence: A Preliminary Study

<div><p>Background</p><p>Emotional intelligence (EI) can be broadly defined as the ability to cope with environmental demands. In the scientific research, however, there is not a univocal precise definition of EI and recent articles have underlined the necessity to explore its biological basis to advance understanding of the construct. The aim of study was to investigate if the antioxidant network may be associated with typical-performance or trait EI.</p><p>Methods</p><p>The study group consisted of 50 women (age, M = 25.10, SD = 3.87). Super Oxide Dismutase (SOD), Catalase (CAT), Glutathione Reductase (GR), and Glutathione Peroxidase (GPx) activities were evaluated on proteins extracted from Peripheral Blood Mononuclear Cells. Participants completed the Italian version of the EQ-i (Bar-On, 1997) as a measure of trait EI.</p><p>Results</p><p>We observed positive and significant correlations between some biological variables and EQ-i scores, and a significant predictive effect of CAT activity when controlling for related biological variables, age, and smoking.</p><p>Conclusions</p><p>Our preliminary study suggests that the antioxidant network may constitute some of trait EI's biological basis. In particular, CAT and the SOD/CAT ratio could be two biological variables involved in some specific components of EI.</p></div

Regression Analysis Summary for Biological Variables Predicting EQ-i Total Score.

<p><i>Note</i>. <i>N</i> = 50. <i>F</i>(5, 44) = 2.86, <i>p</i> = .03, <i>R</i>² = .25, <i>R</i>²_Adj = .16. SOD  =  Super Oxide Dismutase; CAT  =  Catalase; EQ-i  =  Emotional Quotient Inventory.</p