Ultrasonographic Pattern of Testicular Metastasis of Clear Cell Renal Cell Carcinoma with Pathological Correlation

Two cases of testicular metastases of a clear cell renal cell carcinoma sharing a very similar ultrasonographic pattern are reported. The observed pattern – masses containing multiple tiny cyst-like areas – is very similar to that of a previously described ovarian metastasis of clear cell renal parenchymal tumor and can be explained by histopathologic features. Despite the small number of cases, this ultrasonographic pattern of testicular mass may be specific for metastasis of clear cell renal cell carcinoma origin

Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage

Matrix metalloproteinase (MMP)-2 and -9 are pivotal in remodeling many tissues. However, their functions and candidate substrates for brain development are poorly characterized. Intercellular adhesion molecule-5 (ICAM-5; Telencephalin) is a neuronal adhesion molecule that regulates dendritic elongation and spine maturation. We find that ICAM-5 is cleaved from hippocampal neurons when the cells are treated with N-methyl-d-aspartic acid (NMDA) or α-amino-3-hydroxy-5-methylisoxazole-propionic acid (AMPA). The cleavage is blocked by MMP-2 and -9 inhibitors and small interfering RNAs. Newborn MMP-2– and MMP-9–deficient mice brains contain more full-length ICAM-5 than wild-type mice. NMDA receptor activation disrupts the actin cytoskeletal association of ICAM-5, which promotes its cleavage. ICAM-5 is mainly located in dendritic filopodia and immature thin spines. MMP inhibitors block the NMDA-induced cleavage of ICAM-5 more efficiently in dendritic shafts than in thin spines. ICAM-5 deficiency causes retraction of thin spine heads in response to NMDA stimulation. Soluble ICAM-5 promotes elongation of dendritic filopodia from wild-type neurons, but not from ICAM-5–deficient neurons. Thus, MMPs are important for ICAM-5–mediated dendritic spine development

Un nouveau Chloroselas de Centrafrique (Lepidoptera, Lycaenidae, Aphnaeinae)

A new Chloroselas from Central African Republic (Lepidoptera, Lycaenidae, Aphaneinae). A new subspecies of Chloroselas pseudozeritis (Trimen, 1873), C. pseudozeritis ngottoana n. ssp. from Central African Republic, is described. The position of the genus Cesa Seven, 1997, within the Aphnaeinae is determined through phylogenetic analysis.Une nouvelle sous-espèce de Chloroselas pseudozeritis (Trimen, 1873), C. pseudozeritis ngottoana n. ssp. de République centrafricaine, est décrite. La position du genre Cesa Seven, 1997, au sein des Aphnaeinae est précisée grâce à l’analyse phylogénétique.Libert Michel, Annoyer Philippe. Un nouveau Chloroselas de Centrafrique (Lepidoptera, Lycaenidae, Aphnaeinae). In: Bulletin de la Société entomologique de France, volume 120 (1),2015. pp. 31-36

Un nouveau Chloroselas de Centrafrique (Lepidoptera, Lycaenidae, Aphnaeinae)

A new Chloroselas from Central African Republic (Lepidoptera, Lycaenidae, Aphaneinae). A new subspecies of Chloroselas pseudozeritis (Trimen, 1873), C. pseudozeritis ngottoana n. ssp. from Central African Republic, is described. The position of the genus Cesa Seven, 1997, within the Aphnaeinae is determined through phylogenetic analysis.Une nouvelle sous-espèce de Chloroselas pseudozeritis (Trimen, 1873), C. pseudozeritis ngottoana n. ssp. de République centrafricaine, est décrite. La position du genre Cesa Seven, 1997, au sein des Aphnaeinae est précisée grâce à l’analyse phylogénétique.Libert Michel, Annoyer Philippe. Un nouveau Chloroselas de Centrafrique (Lepidoptera, Lycaenidae, Aphnaeinae). In: Bulletin de la Société entomologique de France, volume 120 (1),2015. pp. 31-36

Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation

A

Physiological factors associated with the onset of sweating

The influence of esophageal (Tes) and skin temperature (Tsk) variations, body heat storage, and individual parameters on the initiation of sweating was investigated in 9 unacclimated subjects during thermal transients induced by exercise (25, 50, or 75 W) and by a step change in ambient temperature from 28 degrees C to 23, 28, 36.5, 45, or 50 degrees C. Seventy-four onsets of sweating were observed during the exposures, the sweating delay averaging 3 min at 45 and 50 degrees C, 6 min at 36.5 degrees C, and 9.5 min at 28 degrees C. In warm conditions (36.5 to 50 degrees C), the onset of sweating could mainly be related both to the level of Tsk and its rate component, whereas in cooler conditions (28 and 23 degrees C), the onset of sweating could only be related to a positive rate of Tes variation, the Tsk level being low and steady. On the whole set of data, the Tes changes at the onset were inversely related to the Tsk changes. The cumulated heat storage at the onset of sweating was 37 kJ/m2 (S.D. 25). It varied not only among subjects (range: 11-66 kJ/m2) but also within subjects even when differences in thermal state prior to exercise were accounted for. Among the individual parameters investigated, the magnitude of the decrease in Tes observed in response to the start of exercise was found to have a significant effect on the sweating delay. The Tes decrease was inversely related to the subject's skinfold thickness, and in a given subject, inversely related to the preexercise Tsk. It is concluded that the results are in agreement with a summation model of internal and mean skin temperatures on the sweating drive but that they do not verify the hypothesis of a critical level of heat storage at the onset of sweating

Psychogenesis" of cancer: towards a psycho-neuro-endocrino-immunologicaI way?

info:eu-repo/semantics/publishe

Psychogenesis of cancer: between myths, misuses and reality

info:eu-repo/semantics/publishe