NOVEL SILICON BISALKOXY COMPLEXES WITH A PSEUDO-ATRANE STRUCTURE - SYNTHESIS AND MOLECULAR-STRUCTURES OF 2,6-DI(2-HYDROXY(2-ADAMANTYL))ETHYLPYRIDINE AND 2,6-DI(2-OXY(2-ADAMANTYLIDINE))ETHYLPYRIDINE DIMETHYLSILICON

Reaction of 2,6-lutidine with 2 equivalents of (n)BuLi followed by addition of 2-adamantanone affords the doubly functionalized 2,6-di-(2-oxy(2-adamantylidine))ethylpyridine (2a). Reaction of 2a with Me(2)SiCl(2) gives the pseudo-pentacoordinate 2,6-di-(2-oxy(2-adamantylidine))-ethylpyridinedimethylsilicon (4). The structures of 2a and 4 have been determined by an X-ray diffraction study

Pyridinediols as HCI Receptors; Formation of an Unusual PyridineOHCI Complex in Conjunction with the Preparation of Lewis Acidic Titanium(iv) Centres

Reaction of pyridinediols 1 with TiCl4 affords in one case an unusual dehydration-HCl complexation; in conjunction with these results, reaction of 1 with HCI indicates a strong affinity of these diols for (Lewis) acids

Polycyclic Sulfoximines as New Scaffolds for Drug Discovery

The design and synthesis of three novel polycyclic scaffolds containing sulfoximines are presented in this work, which exemplify that sulfoximines represent a real opportunity for the discovery of new drug candidates. Additionally, the structures present at least two points of diversification and contain a high level of sp³-character, hence being very interesting 3D scaffolds. The compounds synthesized were added to the compound collection of the European Lead Factory