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Development of Substituted Dihydrofurans and 1,2,3-NH-Triazoles through Lewis Base Catalyzed Cascade Condensation and Their Application in Synthesis of Chiral Triazole Derivatives through Mitsunobu Reaction
A one-pot synthesis of substituted dihydrofurans was developed from a Lewis base catalyzed three-component cascade condensation with nitroalkenes, aldehydes and 1,3-dicarbonyl compounds. A large substrate scopes were prepared with excellent diastereoselectivity (trans product only) and excellent yield (up to 95%)
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